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Medicinal plants used against hepatic disorders in Bangladesh: A comprehensive review.

Sep 06, 2021

Liver disease is a major cause of illness and death worldwide which accounts for approximately 2 million deaths per year worldwide, 1 million due to complications of cirrhosis and 1 million due to vir...

Assessment of the phylogenetic analysis and antimicrobial, antiviral, and anticancer activities of marine endophytic Streptomyces species of the soft coral Sarcophyton convolutum.

Aug 26, 2021

In the present work, the extensive biological activities of marine endophytic Streptomyces strains isolated from marine soft coral Sarcophyton convolutum have been demonstrated. Within fifty-one Strep...

A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes.

Aug 26, 2021

Human serine/threonine kinase 4 (STK4) deficiency is a rare, autosomal recessive genetic disorder leading to combined immunodeficiency; however, the extent to which immune signaling and host defense a...

APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy.

Aug 26, 2021

Hepatitis B reactivation related to the use of immunosuppressive therapy remains a major cause of liver-related morbidity and mortality in hepatitis B endemic Asia-Pacific region. This clinical practi...

Audit Of Laboratory Sensitivity Of Human Papillomavirus And Cytology Testing In A Cervical Screening Program.

Aug 23, 2021

The globally recommended public health policy for cervical screening is primary human papillomavirus (HPV) screening with cytology triaging of positives. To ensure optimal quality of laboratory servic...

Identification of Volatile Organic Compounds in the urine of patients with Cervical Cancer. Test concept for timely screening.

Aug 23, 2021

The objective of this research was to identify a global chemical pattern of volatile organic compounds (VOCs) in urine capable of discriminating between women with cervical cancer (CC) and control wom...

Sex differences in the behavioral and immune responses of mice to tumor growth and cancer therapy.

Aug 23, 2021

There is significant variability in the expression of cancer-related fatigue. Understanding the factors that account for this variation provide insight into the underlying mechanisms. One important, b...

Provider-Level Barriers to Human Papillomavirus Vaccination in Survivors of Childhood and Young Adult Cancers.

Aug 19, 2021

We sought to understand clinician-level barriers to providing HPV vaccination to survivors of childhood and young adult cancers (CYACs). We conducted 30-minute qualitative interviews with primary ca...

A viroporin-like 2B protein of duck hepatitis A virus 1 that induces incomplete autophagy in DEF cells.

Aug 19, 2021

Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious hepatitis in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydropho...

Secular trend of treatment uptake in patients with chronic hepatitis B - a territory-wide study of 135,395 patients from 2000 to 2017.

Aug 19, 2021

The uptake of antiviral treatment for patients with chronic hepatitis B (CHB) has been suboptimal. We aimed to determine the secular trend of treatment uptake in the territory-wide CHB cohort in Hong ...

C-terminal-truncated hepatitis B virus X protein promotes hepatocarcinogenesis by activating the MAPK pathway.

Aug 16, 2021

C-terminally truncated hepatitis B virus X (ctHBx) is frequently detected in hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV) integrated into their genomes, but the molecular mecha...

Activation of PPARα-catalase pathway reverses alcoholic liver injury via upregulating NAD synthesis and accelerating alcohol clearance.

Aug 16, 2021

Alcohol metabolism in the liver simultaneously generates toxic metabolites and disrupts redox balance, but the regulatory mechanisms have not been fully elucidated. The study aimed to characterize the...

Polysaccharide extracted from Taraxacum platycarpum root exerts immunomodulatory activity via MAPK and NF-κB pathways in RAW264.7 cells.

Aug 16, 2021

Taraxacum platycarpum Dahlst. (Korean dandelion) is a medicinal herb used in traditional medicine in Korea to treat various disease such as furuncles, mammitis, hepatitis, jaundice. Moreover, a decoct...

A positive HPV test with positive p16/Ki-67 double staining in self-sampled vaginal material is an accurate tool to detect women at risk for cervical cancer.

Aug 12, 2021

The development of efficient strategies for managing high-risk human papillomavirus (HR-HPV)-positive women is a major challenge when human papillomavirus-based primary screening is being performed. T...

Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.

Aug 12, 2021

Development of primary liver cancer is a multi-stage process. Detailed understanding of sequential epigenetic alterations is largely missing. Here, we performed Infinium Human Methylation 450k BeadChi...

Bioactivities of Lentinus polychrous and Ganoderma lucidum (Agaricomycetes) Polysaccharide Extracts.

Aug 12, 2021

This study aimed to compare the bioactivities of Lentinus polychrous polysaccharide extracts with Ganoderma lucidum. Three hot water-extracted polysaccharide fractions of L. polychrous (LPE), includin...

Cure Everyone and Vaccinate the rest: The patient perspective on future hepatitis B treatment.

Aug 09, 2021

Those living with chronic hepatitis B virus (HBV) require years if not decades of regular monitoring to prevent liver complications from occurring. An estimated 292 million people were living with chr...

Infection courses, virological features and IFN-α responses of HBV genotypes in cell culture and animal models.

Aug 09, 2021

Hepatitis B virus (HBV) consists of 9 major genotypes (A to I), one minor strain (designated J) and multiple subtypes, which may have different natural history, disease progression and treatment respo...

Human inborn errors of immunity to oncogenic viruses.

Aug 09, 2021

Oncoviruses are viruses that can cause tumors. Seven viruses are currently recognized as oncogenic in humans: Epstein Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV, also known as HHV8)...

Prevalence and Genotype Distribution of Human Papillomavirus Infection among 12,076 Iranian Women.

Aug 05, 2021

Human papillomavirus (HPV) infection is one of the major health concerns of women in developing countries. This study gives an insight into the prevalence and genotype distribution of HPV infection an...