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Tuberculosis

Disease Surveillance Among U.S.-Bound Immigrants and Refugees - Electronic Disease Notification System, United States, 2014-2019.

Jan 24, 2022

Each year, approximately 500,000 immigrants and tens of thousands of refugees (range: 12,000-85,000 during 2001-2020) move to the United States. While still abroad, immigrants, refugees, and others wh...

Screening differential circular RNA expression profiles reveals the regulatory role of circMARS in anti-tuberculosis drug-induced liver injury.

Jan 17, 2022

Tuberculosis (TB) treatment is plagued by liver damage, which often leads to treatment interruptions. Circular RNAs (circRNAs) are a special class of non-coding RNAs abundant in body fluids with impor...

Efficacy analysis of one-stage posterior-only surgical treatment for thoracic spinal tuberculosis in the T4-6 segments with minimum 5-year follow-up.

Jan 10, 2022

In recent years, with the in-depth research on spinal tuberculosis, posterior surgery alone has been praised highly by more and more surgeons due to the better correction of kyphosis, better maintenan...

Phytochemical and proximate content of Carapa procera bark and its antimicrobial potential against selected pathogens.

Dec 27, 2021

Medicinal plants represent a great source of antimicrobial and phytochemical constituents which are increasingly used to treat microbial infections and other ailments such as tuberculosis, anemia, and...

Lactic acidosis associated with standard dose linezolid in a kidney recipient with impaired renal function.

Dec 27, 2021

Severe lactic acidosis, a mitochondrial toxicity caused by the recommended standard dosage of linezolid (LZD), may occur in patients with impaired renal function. We describe an adult male who underwe...

Franz Tappeiner (1816-1902) and his pioneering studies on tuberculosis.

Dec 20, 2021

Franz Tappeiner (1816-1902) was an Austrian scientist: physician and anthropologist. He studied medicine at the universities of Prague and Padua, and completed his medical education receiving his doct...

Global Outsourcing and Local Tendering Supply Chain Systems in the Public Healthcare Sector: A Cost Comparison Analysis, Namibia.

Dec 20, 2021

To compare supplier prices for local tendering and global outsourcing supply chain systems that are used to purchase pharmaceutical products by the Ministry of Health in Namibia and to compare the sup...

A multifactorial assessment of the SRP pathway constituent FtsY as a vital mycobacterial constituent.

Nov 29, 2021

The signal recognition particle (SRP) system plays an imperative role in transporting the secretory protein to its intended location. The SRP pathway running in Mycobacterium tuberculosis constitutes ...

Discordant results between genotypic and phenotypic assays (Xpert MTB/RIF vs. BACTEC MGIT 960 system) for detection of RIF-resistant Mycobacterium tuberculosis isolates in a high burden region.

Nov 22, 2021

Clinical isolates with discordant phenotypic and genotypic results were submitted to DNA sequencing to identify which were genuinely resistant to rifampin and determine the frequency of silent and dis...

[A comparative study on the difference of gut microbiota and its biomarkers between patients with pulmonary tuberculosis and healthy controls].

Nov 15, 2021

To analyze the differences in the composition and abundance of gut microbiota between patients with active pulmonary tuberculosis and healthy controls, and to identify the specific bacteria as biomar...

Patient and healthcare delays in critical and non-critical pulmonary tuberculosis incidence areas in Portugal: are there differences?

Nov 08, 2021

To characterize patient, healthcare, and total delay in diagnosing pulmonary tuberculosis (PTB) in critical (higher PTB incidence) and non-critical (lower PTB incidence) areas and their determinants c...

Benchtop nuclear magnetic resonance-based metabolomic approach for the diagnosis of bovine tuberculosis.

Nov 01, 2021

Even though enormous efforts and control strategies have been implemented, bovine tuberculosis (TB) remains a significant source of health and socioeconomic concern. The standard method used in TB era...

LC-MS/MS method for simultaneous quantification of the first-line anti-tuberculosis drugs and six primary metabolites in patient plasma: Implications for therapeutic drug monitoring.

Oct 25, 2021

The pharmacokinetic profiling of drug substances and corresponding metabolites in the biological matrix is one of the most informative tools for the treatment efficacy assessment. Therefore, to satisf...

Intracranial tuberculomas: A case report of clinical, radiological, and pathological characteristics.

Oct 18, 2021

Intracranial tuberculomas are uncommon yet devastating forms of extrapulmonary tuberculosis with a high mortality rate and morbidity risk. A high level of suspicion is required for a prompt diagnosis ...

Automatic cough classification for tuberculosis screening in a real-world environment.

Oct 18, 2021

textit{Objective:} The automatic discrimination between the coughing sounds produced by patients with tuberculosis (TB) and those produced by patients with other lung ailments. textit{Approach:} We pr...

Exposure-safety analysis of QTc interval and transaminase levels following bedaquiline administration in patients with drug-resistant tuberculosis.

Oct 11, 2021

Bedaquiline (BDQ) has shown great value in the treatment of multidrug-resistant tuberculosis (MDR-TB) in recent years. However, exposure-safety relationships must be explored to extend the use of BDQ....

Global Prevalence and Clinical Outcomes of Tubercular Uveitis: A Systematic Review and Meta-analysis.

Oct 11, 2021

Tubercular uveitis (TBU) is an inflammation/infection of the eye secondary to Mycobacterium tuberculosis infection. The difficulty in making the diagnosis has resulted in variable prevalence and clini...

Whole genome sequencing for surveillance of tuberculosis drug resistance and determination of resistant level in China.

Oct 04, 2021

Phenotypic drug susceptibility testing for prediction of tuberculosis (TB) drug resistance is slow and unreliable, limiting individualized therapy and monitoring of national TB data. Our study evaluat...

Treatment Incompletion of Tuberculosis in Patients with Lung Cancer: the Occurrence and Prediction Factors.

Oct 04, 2021

Patients with lung cancer are at high risk for active tuberculosis (TB) but fragile status and drug-drug interaction might lead TB treatment interrupted. However, the occurrence and the predictors of ...

Ruminant farmers' knowledge, attitude and practices towards zoonotic diseases in Selangor, Malaysia.

Sep 20, 2021

This study aimed to assess knowledge, attitude and practices about zoonotic diseases and associated factors among ruminant farmers in Selangor, Malaysia. A cross-sectional survey was conducted between...