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Tuberculosis

Recent advances in synthesis and medicinal chemistry of benzodiazepines.

Feb 28, 2020

Benzodiazepines (BZDs) represent a diverse class of bicyclic heterocyclic molecules. In the last few years, benzodiazepines have emerged as potential therapeutic agents. As a result, several mild, eff...

Change in TB diagnostic profile after introduction of GeneXpert MTB/RIF assay in National TB Program of Armenia, 2013-2017.

Feb 13, 2020

In 2013, the National Tuberculosis (TB) Program of Armenia introduced GeneXpert MTB/RIF (Xpert) assay to address World Health Organization (WHO) target of 80% (2020) of notified new and relapse TB cas...

Quality of care provided to tuberculosis patients in Armenia: How satisfied are the patients?

Feb 13, 2020

Adherence to tuberculosis (TB) treatment as an important determinant for the successful cure of patients can be increased by focusing on patient satisfaction. The objective of this study was to evalua...

A country-wide evaluation of infection control for tuberculosis in health-care facilities in Armenia.

Feb 13, 2020

Infection control at health facilities is an important part of TB control programmes. To assess the implementation of tuberculosis infection control (TB IC) measures and barriers hindering their imple...

Warthin's tumor with necrotizing tuberculous granulomatous inflammation causing severe facial nerve adhesion in parotid gland: A case report and literature review.

Feb 13, 2020

Warthin's tumor is the second most common tumor arising from the parotid gland, but it rarely occurs concomitantly with tuberculous granulomatous inflammation with only 13 documented case reports in t...

Memory B cells and tuberculosis.

Feb 13, 2020

Immunological memory is a central feature of adaptive immunity. Memory B cells are generated upon stimulation with antigen presented by follicular dendritic cells in the peripheral lymphoid tissues. T...

Low Resource Nucleic Acid Extraction Method Enabled by High-Gradient Magnetic Separation.

Feb 11, 2020

Nucleic acid-based diagnostic tests often require isolation and concentration of nucleic acids from biological samples. Commercial purification kits are difficult to use in low-resource settings due t...

Antimicrobial usage at a large teaching hospital in Lusaka, Zambia.

Feb 11, 2020

Antimicrobial resistance is a growing global health concern. Antimicrobial stewardship (AMS) curbs resistance rates by encouraging rational antimicrobial use. However, data on antimicrobial stewardshi...

E-cigarettes: Effects in phagocytosis and cytokines response against Mycobacterium tuberculosis.

Feb 11, 2020

Cigarette smoking and tuberculosis are a significant cause of death worldwide. Several epidemiological studies have demonstrated cigarette smoking is a risk factor for tuberculosis. Electronic cigaret...

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response.

Feb 11, 2020

There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatmen...

Genetic, Immunological, and Clinical Features of the First Mexican Cohort of Patients with Chronic Granulomatous Disease.

Feb 11, 2020

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by an inability of phagocytes to produce reactive oxygen species, impairing their killing of various bacteria and fungi....