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Tuberculosis

Treatment Incompletion of Tuberculosis in Patients with Lung Cancer: the Occurrence and Prediction Factors.

Oct 04, 2021

Patients with lung cancer are at high risk for active tuberculosis (TB) but fragile status and drug-drug interaction might lead TB treatment interrupted. However, the occurrence and the predictors of ...

Ruminant farmers' knowledge, attitude and practices towards zoonotic diseases in Selangor, Malaysia.

Sep 20, 2021

This study aimed to assess knowledge, attitude and practices about zoonotic diseases and associated factors among ruminant farmers in Selangor, Malaysia. A cross-sectional survey was conducted between...

NDK/NME proteins: a host-pathogen interface perspective towards therapeutics.

Sep 06, 2021

No effective vaccine is available for any parasitic disease. The treatment to those is solely dependent on chemotherapy, which is always threatened due to development of drug resistance in bugs. This ...

Guidelines for Infection Control in the Urological Field, including Urinary Tract Management (revised second edition).

Sep 06, 2021

The Committee for the Development of Guidelines for Infection Control in the Urological Field, including Urinary Tract Management of the Japanese Urological Association, together with its systematic r...

iAtbP-Hyb-EnC: Prediction of antitubercular peptides via heterogeneous feature representation and genetic algorithm based ensemble learning model.

Sep 06, 2021

Tuberculosis (TB) is a worldwide illness caused by the bacteria Mycobacterium tuberculosis. Owing to the high prevalence of multidrug-resistant tuberculosis, numerous traditional strategies for develo...

Neutrophils contribute to severity of tuberculosis pathology and recovery from lung damage pre- and post-treatment.

Aug 26, 2021

Despite microbiological cure, about 50% of TB patients have poor lung recovery. Neutrophils are associated with lung pathology, however, CD16|CD62L-defined subsets have not been studied in TB. Using f...

Structural and ATPase activity analysis of nucleotide binding domain of Rv3870 enzyme of M. tuberculosis ESX-1 system.

Aug 26, 2021

The EccC enzyme of ESX-1 system contains (i) a membrane bound Rv3870 with single ATPase domain and (ii) a cytoplasmic Rv3871 with two ATPase domains and involved in secretion of ESAT6/CFP10 factor out...

Epidemiology, clinical features and outcomes of incident tuberculosis in children in Canada in 2013-2016: results of a national surveillance study.

Aug 23, 2021

Childhood tuberculosis disease is difficult to diagnose and manage and is an under-recognised cause of morbidity and mortality. Reported data from Canada do not focus on childhood tuberculosis or capt...

Toward strengthening active case finding for ending tuberculosis in India.

Aug 23, 2021

Active case finding (ACF) is critical for the timely detection and treatment of diseases like tuberculosis (TB). ACF is crucial in India, where health-seeking behaviour across various populations is l...

Novel C-3-(N-alkyl-aryl)-aminomethyl rifamycin SV derivatives exhibit activity against rifampicin-resistant Mycobacterium tuberculosis RpoB strain and display a different binding mode at the RNAP β-subunit site compared to rifampicin.

Aug 23, 2021

Antimicrobial resistance is a main concern in tuberculosis treatment and is often associated with the emergence of Mycobacterium tuberculosis strains resistant to rifampicin (RIF), which is one of the...

A Semi-Mechanistic Model of the Bactericidal Activity of High-Dose Isoniazid Against Multi-Drug-Resistant Tuberculosis: Results from a Randomized Clinical Trial.

Aug 19, 2021

There is accumulating evidence that higher-than-standard doses of isoniazid are effective against low-to-intermediate-level isoniazid-resistant strains of Mycobacterium tuberculosis, but the optimal d...

CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice.

Aug 19, 2021

More humans have died of tuberculosis (TB) than any other infectious disease and millions still die each year. Experts advocate for blood-based, serum protein biomarkers to help diagnose TB, which aff...

Koumiss promotes Mycobacterium bovis infection by disturbing intestinal flora and inhibiting endoplasmic reticulum stress.

Aug 19, 2021

Mycobacterium bovis is the causative agent of bovine tuberculosis and also responsible for serious threat to public health. Koumiss is a fermented mare's milk product, used as traditional drink. Here,...

Social Distance in COVID-19: Drawing the line between protective behavior and stigma manifestation.

Aug 16, 2021

Social stigma has long been defined by Ervin Goffman as an attribute that it is deeply discrediting and reduces the individual who bears it from a whole and usual person to a tarnished one, unfit to b...

Prevalence and factors associated with depressive illness in patients with tuberculosis in Mulago hospital, Kampala- Uganda: A cross sectional study.

Aug 16, 2021

Depression is a major cause of the global disease burden and globally affects 350-400 million persons making it the largest contributor to years lived with disability. Among of patients with chronic p...

Development and clinical evaluation of a new multiplex PCR assay for a simultaneous diagnosis of tuberculous and nontuberculous mycobacteria.

Aug 16, 2021

The prevalence of non-tuberculous mycobacteria (NTM) has been increasing worldwide in both developed and developing countries. NTM infection is clinically indistinguishable from tuberculosis and there...

Health-related quality of life after pulmonary tuberculosis in South Korea: analysis from the Korea National Health and Nutrition Examination Survey between 2010 and 2018.

Aug 12, 2021

Although several studies have reported an association between tuberculosis and health-related quality of life, the change in health-related quality of life after pulmonary tuberculosis has been rarely...

Host Lipidome and Tuberculosis Treatment Failure.

Aug 12, 2021

Host lipids play important roles in Tuberculosis (TB) pathogenesis. Whether host lipids at TB treatment initiation (baseline) affect subsequent treatment outcomes has not been well-characterised. We u...

A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment.

Aug 12, 2021

Standardized dosing of anti-tubercular drugs contributes to a substantial incidence of toxicities, inadequate treatment response, and relapse, in part due to variable drug levels achieved. Single nucl...

A genetic variant in the TRAF1/C5 gene lead susceptibility to active pulmonary tuberculosis by decreased TNF-α levels.

Aug 09, 2021

Host genetics are important to consider in the role of resistance or susceptibility for developing active pulmonary tuberculosis (TB). Several association studies have reported the role of variants in...