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Tuberculosis

Identification of lncRNA and mRNA expression profiles in dorsal root ganglion in rats with cancer-induced bone pain.

Aug 09, 2021

Cancer-induced bone pain (CIBP) is one of the most severe types of chronic pain which the involved mechanisms are largely unknown. LncRNA has been found to play critical roles in chronic pain. However...

Indoor Air Pollution and Susceptibility to Tuberculosis Infection in Urban Vietnamese Children.

Aug 05, 2021

The Southeast Asian tuberculosis burden is high, and it remains unclear if urban indoor air pollution in this setting is exacerbating the epidemic.To determine the associations of latent tuberculosis ...

Pattern of Drug Resistance in Primary Spinal Tuberculosis: A Single-Center Study From India.

Aug 05, 2021

Retrospective observational analysis.Spinal tuberculosis accounts for about 50% of cases among extra pulmonary osteoarticular tuberculosis. Resistance to drugs in spinal tuberculosis patients is on a ...

Epitope mapping from Mycobacterium leprae proteins: Convergent data from in silico and in vitro approaches for serodiagnosis of leprosy.

Aug 05, 2021

Knowledge of immunodominant B-cell epitopes is essential to design powerful diagnostic strategies aiming for antibody detection. Outstanding progress in computational prediction has achieved a signifi...

The blood neutrophil count after 1 month of treatment predicts the radiological severity of lung disease at treatment end.

Aug 02, 2021

Post-tuberculous lung disease confers significant morbidity. However, the determinants of persistent lung damage in tuberculosis are not well established. We investigated associations between tubercul...

Tuberculosis recurrence over 7-year follow-up period in successfully treated patients in a routine programme setting in China: a prospective longitudinal study.

Aug 02, 2021

To determine tuberculosis (TB) recurrence in previously successfully treated patients in routine program setting and baseline characteristics associated with TB recurrence.A prospective longitudinal s...

Immunoinformatics analysis of antigenic epitopes and designing of a multi-epitope peptide vaccine from putative nitro-reductases of M. tuberculosis DosR.

Aug 02, 2021

Mycobacterium tuberculosis resides in alveolar macrophages as a non-dividing and dormant state causing latent tuberculosis. Currently, no vaccine available against the latent tuberculosis. Latent Mtb ...

Use of blood matrices and alternative biological fluids for antibody detection in animal tuberculosis.

Jul 29, 2021

Bovine tuberculosis (bTB) control programs can be improved by implementation of advanced ante-mortem testing algorithms. Serodiagnostic methods using traditional blood or blood-derived specimens may b...

Mycobacterial diseases in patients with inborn errors of immunity.

Jul 29, 2021

Clinical disease caused by the agent of tuberculosis, Mycobacterium tuberculosis, and by less virulent mycobacteria, such as bacillus Calmette-Guérin (BCG) vaccines and environmental mycobacteria, ca...

Role of hematopoietic cells in Mycobacterium tuberculosis infection.

Jul 29, 2021

Tuberculosis remains one of the most significant causes of mortality worldwide and the current situation shows a re-emergence of TB due to the emergence of new antibiotic-resistant strains and the wid...

Biochemical Approaches to Probe the Role of the Auxiliary Iron-Sulfur Cluster of Lipoyl Synthase from Mycobacterium Tuberculosis.

Jul 26, 2021

Lipoic acid is an essential sulfur-containing cofactor used by several multienzyme complexes involved in energy metabolism and the breakdown of certain amino acids. It is composed of n-octanoic acid w...

Prioritization of neglected tropical zoonotic diseases: A one health perspective from Tigray region, Northern Ethiopia.

Jul 26, 2021

Neglected tropical zoonotic diseases (NTZDs) continue to have a major effect on the health of humans and animals. In this study, a one health approach was used to prioritize and rank neglected tropica...

Safety, efficacy, and serum concentration monitoring of bedaquiline in Chinese patients with multidrug-resistant tuberculosis.

Jul 26, 2021

To determine the safety and efficacy of bedaquiline for Chinese multidrug-resistant tuberculosis patients based on serum concentration monitoring and identify factors associated with QTc prolongation ...

Reducing the risk of tuberculosis transmission for HCWs in high incidence settings.

Jul 22, 2021

Globally, tuberculosis (TB) is a leading cause of death from a single infectious agent. Healthcare workers (HCWs) are at increased risk of hospital-acquired TB infection due to persistent exposure to ...

Predicting Antituberculosis Drug-Induced Liver Injury Using an Interpretable Machine Learning Method: Model Development and Validation Study.

Jul 22, 2021

Tuberculosis (TB) is a pandemic, being one of the top 10 causes of death and the main cause of death from a single source of infection. Drug-induced liver injury (DILI) is the most common and serious ...

Circulating IgA/IgG memory B cell against Mycobacterium tuberculosis dormancy-associated antigens Rv2659c and Rv3128c in active and latent tuberculosis.

Jul 22, 2021

To elucidate the antigenic potential of dormancy-associated antigen Rv2659c and Rv3128c of Mycobacterium tuberculosis by examining the persistence of specific IgG and IgA memory B cells (MBCs) among p...

Tanshinones from Salvia miltiorrhiza inhibit Mycobacterium tuberculosis via disruption of the cell envelope surface and oxidative stress.

Jul 19, 2021

The unique structure of Mycobacterium tuberculosis cell envelope provides impermeable barrier against environmental stimuli. In the situation that this barrier is disturbed Mycobacteria react at the t...

Efficacy and Safety of Combined Isoniazid-Rifampicin-Pyrazinamide-Levofloxacin Dry Powder Inhaler in Treatment of Pulmonary Tuberculosis: A Randomized Controlled Trial.

Jul 19, 2021

To determine the efficacy and safety of add-on dry powder for inhalation (DPI) of combined anti-TB agents prepared as a particulate system (study group) compared with placebo DPI (control group) in pa...

Molecular epidemiology and drug susceptibility profiles of Mycobacterium tuberculosis complex isolates from Northern Ghana.

Jul 19, 2021

We conducted a cross sectional study in the five administrative regions of Northern Ghana to determine the diversity of Mycobacterium tuberculosis complex (MTBC) sub/lineages and their susceptibility ...

Impact of Isoniazid Preventive Therapy on Tuberculosis incidence among people living with HIV: A secondary data analysis using Inverse Probability Weighting of individuals attending HIV care and treatment clinics in Tanzania.

Jul 15, 2021

Information on how well Isoniazid Preventive Therapy (IPT) works on reducing TB incidence among people living with HIV (PLHIV) in routine settings using robust statistical methods to establish causali...