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Zika Virus

Co-learning during the co-creation of a dengue early warning system for the health sector in Barbados.

Jan 10, 2022

Over the past decade, the Caribbean region has been challenged by compound climate and health hazards, including tropical storms, extreme heat and droughts and overlapping epidemics of mosquito-borne ...

In silico construction of a multiepitope Zika virus vaccine using immunoinformatics tools.

Jan 10, 2022

Zika virus (ZIKV) is an arbovirus from the Flaviviridae family and Flavivirus genus. Neurological events have been associated with ZIKV-infected individuals, such as Guillain-Barré syndrome, an autoi...

The Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor.

Jan 03, 2022

Killer cell immunoglobulin-like receptors (KIRs) are important receptors for regulating the killing of virus-infected or cancer cells of natural killer (NK) cells. KIR2DS2 can recognize peptides deriv...

CISH and IHC for the Simultaneous Detection of ZIKV RNA and Antigens in Formalin-Fixed Paraffin-Embedded Cell Blocks and Tissues.

Dec 27, 2021

Zika virus is an arthropod-borne virus that has recently emerged as a significant public health emergency due to its association with congenital malformations. Serological and molecular tests are typi...

Reactions to geographic data visualization of infectious disease outbreaks: an experiment on the effectiveness of data presentation format and past occurrence information.

Dec 27, 2021

This study intended to compare the effectiveness of thematic maps with that of tabular data in comprehension and memory of risk magnitudes, with Zika virus (ZIKV) disease outbreaks in the United State...

Synthesis of 6-Aza-2-Hydroxyimino-5-Methylpyrimidine Nucleosides for Antiviral Evaluation.

Dec 13, 2021

The syntheses of a series of novel 6-aza-2-hydroxyimino-5-methylpyrimidine and related nucleosides are described. A suitably protected 2-methylthiopyrimidine nucleoside was selected as the precursor f...

Neighbourhood-level income and Zika virus infection during pregnancy in Recife, Pernambuco, Brazil: an ecological perspective, 2015-2017.

Dec 06, 2021

Zika virus (ZIKV) infections during pregnancy can lead to adverse neurodevelopmental and clinical outcomes in congenitally infected offspring. As the city of Recife in Pernambuco State, Brazil-the epi...

Intrauterine Viral Infections: Impact of Inflammation on Fetal Neurodevelopment.

Dec 06, 2021

Intrauterine viral infections during pregnancy by pathogens such as Zika virus, Cytomegalovirus, Rubella and Herpes Simplex virus can lead to prenatal as well as postnatal neurodevelopmental disorders...

Immuno-informatics guided designing of a multi-epitope vaccine against Dengue and Zika.

Nov 22, 2021

Dengue and zika are amongst the most prevalent mosquito-borne diseases caused by closely related members Dengue virus (DENV) and Zika virus (ZIKV), respectively, of the family. DENV and ZIKV have bee...

Zika virus NS1 protein suppresses the innate immune responses via miR-146a in human microglial cells.

Nov 22, 2021

Zika virus (ZIKV) is a positive-single strand RNA virus that belongs to the Flaviviridae family. ZIKV infection causes congenital ZIKV syndrome (CZS) in children and Guillain Barre Syndrome (GBS) in a...

Structurally conserved domains between flavivirus and alphavirus fusion glycoproteins contribute to replication and infectious virion production.

Nov 15, 2021

Alphaviruses and flaviviruses have class II fusion glycoproteins that are essential for virion assembly and infectivity. Importantly, the tip of domain II is structurally conserved between the alphavi...

[The CCM Project "Preventing vector-borne diseases through the development and pilot implementation of new operational supporting tools"].

Nov 08, 2021

The relevant ecological changes due to the anthropological pressure on the planet is causing reactions in the biological systems, which we must understand and characterize at the local scale to assist...

A DREaMR system to simplify combining mutations with rescue transgenes in Aedes aegypti.

Nov 08, 2021

In most experimental animals, it is challenging to combine mutations and rescue transgenes and to use bipartite systems to assess gene expression. To circumvent the difficulties in combining multiple ...

Purification of Dengue and Zika Virus Non-structural Protein 5 for Crystallization and Screening of Antivirals.

Nov 01, 2021

Dengue Virus (DENV) and ZIKA Virus (ZIKV) are two important human pathogens that belong to the Flavivirus genus of positive strand RNA viruses. Symptoms of DENV infections range from asymptomatic or m...

Uncovering the genetic diversity within the virome and isolation of new viruses from this highly urbanised and invasive mosquito.

Nov 01, 2021

The Australian backyard mosquito, , is a highly urbanised pest species that has invaded New Zealand and the USA. Importantly, has been implicated as a vector of Ross River virus, a common and arthrit...

ML-SA1 and SN-2 inhibit endocytosed viruses through regulating TRPML channel expression and activity.

Oct 25, 2021

Transient receptor potential mucolipin 2 and 3 (TRPML2 and TRPML3), as key channels in the endosomal-lysosomal system, are associated with many different cellular processes, including ion release, mem...

Efficacy and safety of repellents marketed in Brazil against bites from Aedes aegypti and Aedes albopictus: A systematic review.

Oct 25, 2021

Dengue, Zika and Chikungunya viruses represent a serious public health problem. No evidence is available on the efficacy of repellents commercially available in Brazil. This systematic review assessed...

Indirect transfer of pyriproxyfen to European honeybees via an autodissemination approach.

Oct 18, 2021

The frequency of arboviral disease epidemics is increasing and vector control remains the primary mechanism to limit arboviral transmission. Container inhabiting mosquitoes such as Aedes albopictus an...

Synergistic in-vitro antiviral effects of combination treatment using anidulafungin and T-1105 against Zika virus infection.

Oct 18, 2021

Zika virus (ZIKV) has been the cause of some epidemics since 2007. The correlations of microcephaly and Guillain-Barré syndrome with ZIKV have been noticed. Unfortunately, researchers have yet to dev...

Viral genome-based Zika virus transmission dynamics in a paediatric cohort during the 2016 Nicaragua epidemic.

Oct 11, 2021

Nicaragua experienced a large Zika epidemic in 2016, with up to 50% of the population in Managua infected. With the domesticated Aedes aegypti mosquito as its vector, it is widely assumed that Zika vi...