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CKD

A Prospective cross-sectional study estimated glomerular filtration rate from creatinine and cystatin C in adults with solid tumors.

Jan 17, 2022

Current guidelines recommend estimating glomerular filtration rate (eGFR) using creatinine (eGFRcr) with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation as the first test for ...

KCNQ1OT1 inhibition alleviates high glucose-induced podocyte injury by adsorbing miR-23b-3p and regulating Sema3A.

Jan 10, 2022

Diabetic nephropathy (DN), a diabetic complication, is the leading cause of end-stage renal disease. KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), a long non-coding RNA, has been unmasked t...

External validation of prognostic models for chronic kidney disease among type 2 diabetes.

Jan 10, 2022

Various prognostic models have been derived to predict chronic kidney disease (CKD) development in type 2 diabetes (T2D). However, their generalisability and predictive performance in different popula...

Evaluating Self-Efficacy among Patients Undergoing Dialysis Therapy.

Jan 03, 2022

(1) Background: Perceived disease-related self-efficacy is considered a fundamental component of the successful self-management of chronic diseases. Prior studies have found that self-efficacy is asso...

Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway.

Jan 03, 2022

Tubulointerstitial fibrosis is a common pathway of chronic kidney disease (CKD) and is closely related to the progression of CKD. LMCD1, acting as an intermediary, has been reported to play a role in ...

Renal Senescence, Telomere Shortening and Nitrosative Stress in Feline Chronic Kidney Disease.

Dec 27, 2021

Kidney tissues from cats with naturally occurring chronic kidney disease (CKD) and adult and senior cats without CKD were assessed to determine whether telomere shortening and nitrosative stress are a...

The nature and prognosis of renal diseases in chronic hepatitis-C-infected diabetic Egyptian patients: The role of renal biopsy.

Dec 27, 2021

Egypt has a wide prevalence of Diabetes and chronic HCV infection. The relationship between diabetes and HCV is bidirectional and both have their impact on kidney. The aim is to study the exact diagno...

Associations Between Myocardial Diastolic Dysfunction and Cardiovascular Mortality in Chronic Kidney Disease: A Large Single-Center Cohort Study.

Dec 20, 2021

The clinical burden and prognostic role of diastolic dysfunction (DD), based on the latest American Society of Echocardiography (ASE) 2016 guidelines, remains unclear in patients with chronic kidney d...

Primary Nephrotic Syndrome in Children: Identifying Patients & Examining Trends

Dec 07, 2021

Nephrotic syndrome is a relatively uncommon kidney disorder, but it can lead to potentially severe long-term kidney-related and cardiovascular outcomes in children. Research shows that children with t...

Pre-surgical chronic kidney disease continues to drive outcomes in the modern era of minimally invasive renal surgery, despite advances in technology.

Nov 29, 2021

To assess the impact of preoperative chronic kidney disease (CKD) on perioperative morbidity and mortality in a contemporary cohort undergoing renal surgery in an era of increased prevalence of minima...

Impact of Calcium Channel Blockers on Aspirin Reactivity in Patients with Coronary Artery Disease.

Nov 22, 2021

Calcium channel blockers (CCBs) do not reduce the risk of initial or recurrent myocardial infarction (MI) in patients diagnosed with stable coronary artery disease (CAD). The aim of this current study...

Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation.

Nov 22, 2021

The initial clinical trials of pig solid organ xenotransplantation (XTx) are drawing closer and could begin in the coming years. The first clinical trials may aim to transplant genetically-modified pi...

Recent and Emerging Therapies for Iron Deficiency in Anemia of CKD: A Review.

Nov 15, 2021

Iron deficiency commonly contributes to the anemia affecting individuals with chronic kidney disease. Diagnostic criteria for iron deficiency in chronic kidney disease are explained. Mechanisms of fun...

Renin-Angiotensin System Blockade is Associated with Exercise Capacity, Sympathetic Activity and Endothelial Function in Patients with Chronic Kidney Disease.

Nov 15, 2021

Chronic kidney disease (CKD) patients have exercise intolerance and exaggerated blood pressure reactivity during exercise that are mediated by sympathetic nervous system (SNS) overactivation and decre...

Cashew-Induced Oxalate Nephropathy: A Rare Cause of Acute Renal Failure.

Nov 08, 2021

We present a rare case of cashew-induced oxalate nephropathy in a 69 year old veteran male with history of type 2 diabetes mellitus, nephrolithiasis, and undiagnosed chronic kidney disease (CKD). Ox...

Role of air pollution in chronic kidney disease: an update on evidence, mechanisms and mitigation strategies.

Nov 01, 2021

Air pollution results from a variable and complex mixture of harmful gases and suspended particles and is the most worrisome of all environmental hazards. It is implicated in several non -communicable...

Kidney utilization and outcomes of liver transplant recipients who were listed for kidney after liver transplant after the implementation of safety net policy.

Nov 01, 2021

In 2017, UNOS established the safety net policy with set criteria for offering kidney transplantation (KT) for patients who developed end stage renal disease between 60 and 365 days after LT. We provi...

WEIGHT-BASED INSULIN DURING AND AFTER IV INSULIN INFUSION REDUCES RATES OF REBOUND HYPERGLYCEMIA WHEN TRANSITIONING TO SUBCUTANEOUS INSULIN IN THE MICU.

Oct 25, 2021

Hyperglycemia often occurs after transition from intravenous insulin infusion (IVII) to subcutaneous insulin. Weight-based basal insulin initiated earlier in the course of the IVII in the MICU, and a ...

EVALUATING PREDICTION METHODS FOR GLOMERULAR FILTRATION TO OPTIMISE DRUG DOSES IN OBESE AND NON-OBESE PATIENTS.

Oct 25, 2021

The most suitable method for predicting the glomerular filtration rate (GFR) in obesity is currently debated. Therefore, multiple GFR/creatinine clearance prediction methods were applied to (morbidly)...

Ataxia Telangiectasia and Rad3-Related Activation by DNA Damage Mitigates Maladaptive Repair after Acute Kidney Injury.

Oct 18, 2021

DNA damage is an important consequence of injury to the proximal tubule. The proximal tubule cell responds to this damage by mounting a DNA damage response (DDR). Two protein kinases, ataxia-telangiec...