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ESRD

Race/Ethnic Disparities Vary by Age in Kidney Failure Therapies

Aug 05, 2022

Younger Blacks and Hispanics are less likely than non-Hispanic Whites to undergo transplant or home hemodialysis treatment after kidney replacement treatment. Among patients with  kidney failu...

Association between serum β2-microglobulin and mortality in Japanese peritoneal dialysis patients: A cohort study.

Apr 18, 2022

Higher serum β2-microglobulin (B2M) concentrations are associated with higher mortality in the general population, non-dialyzed chronic kidney disease patients and patients receiving hemodialysis (HD...

Impact of early postoperative creatinine increase on mid-term renal function after cystectomy.

Apr 04, 2022

To determine whether early acute kidney injury affects mid-term renal function, to identify risk factors for impaired mid-term renal function, and to highlight the evolution of plasma creatinine and e...

Highly sensitive simultaneous quantification of indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high performance liquid chromatography coupled with tandem mass spectrometry.

Mar 07, 2022

Indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid are uremic toxins that accumulate in renal failure, and have been reported to decrease the activities of the drug metabolizing enz...

Self-Reported Health Outcomes of Children and Youth with 10 Chronic Diseases.

Mar 07, 2022

To identify pediatric patient-reported outcomes (PROs) that are associated with chronic conditions and to evaluate the effects of chronic disease activity on PROs.Participants 8-24 years-old and their...

Diuretics Not Independently Linked With CKD Progression

Mar 01, 2022

“Different types of diuretic drugs are widely used to help treat high blood pressure, fluid management, and electrolyte abnormalities in patients with CKD, but there is limited data on the effective...

Could high heat cooking and food processing promoting neo-formed contaminants partially explain the high prevalence of chronic kidney disease in South Asian populations? A hypothesis.

Feb 21, 2022

The occurrence of chronic heart and kidney diseases among the South Asian populations has been rising exponentially over the years. Research has been carried out in the past to explain the increased s...

Renin-angiotensin system inhibitors combined with cisplatin exacerbate cisplatin-induced nephrotoxicity in mice.

Feb 21, 2022

We previously reported that the concomitant use of enalapril and telmisartan exacerbates the risk of cisplatin (CDDP)-induced acute renal dysfunction compared to other antihypertensive drugs in mice. ...

Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes.

Jan 24, 2022

To evaluate the association of a multicomponent advanced glycation end product (AGE) panel with decline in kidney function and its utility in predicting renal function loss (RFL) when added to routine...

Effect of Leflunomide on Pegloticase Response Rate in Patients with Uncontrolled Gout: A Retrospective Study.

Jan 10, 2022

Pegloticase, a PEGylated uricase for uncontrolled gout, rapidly lowers serum urate (SU). Not all patients complete a full-therapy course because anti-pegloticase antibodies can develop, causing effica...

A novel role of BK potassium channel activity in preventing the development of kidney fibrosis.

Jan 03, 2022

Kidney fibrosis is a common characteristic of chronic kidney disease and while the large conductance voltage and calcium-activated potassium channel (BK) is widely expressed in kidneys, its role in ki...

Primary Nephrotic Syndrome in Children: Identifying Patients & Examining Trends

Dec 07, 2021

Nephrotic syndrome is a relatively uncommon kidney disorder, but it can lead to potentially severe long-term kidney-related and cardiovascular outcomes in children. Research shows that children with t...

Acute Treatment Effects on GFR in Randomized Clinical Trials of Kidney Disease Progression.

Dec 06, 2021

Acute changes in glomerular filtration rate (GFR) can occur following initiation of interventions targeting progression of chronic kidney disease (CKD). These acute changes complicate the interpretat...

Effects of AST-120 on muscle health and quality of life in chronic kidney disease patients: results of RECOVERY study.

Dec 06, 2021

The prevalence of sarcopenia is increased with declining renal function. Elevated serum indoxyl sulfate levels are associated with poor skeletal muscle conditions. We aimed to determine the effects of...

Huangjinsan ameliorates adenine-induced chronic kidney disease by regulating metabolic profiling.

Oct 25, 2021

Chronic kidney disease is an increasingly serious public health problem worldwide. Our recent studies have shown that Huangjinsan has a renal protective effect on chronic kidney disease, but the speci...

Neutrophil-to-Lymphocyte Ratio and Erythropoietin Resistance among Maintenance Hemodialysis Patients.

Oct 18, 2021

Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are recent prognostic biomarkers associated with inflammation. Increased erythropoiesis resistance index (ERI) may predict the ris...

Extended-release calcifediol in stage 3-4 chronic kidney disease: a new therapy for the treatment of secondary hyperparathyroidism associated with hypovitaminosis D.

Oct 11, 2021

A high percentage of patients with chronic kidney disease have hypovitaminosis D, which is a driver of secondary hyperparathyroidism and an important factor in chronic kidney disease-mineral and bone ...

Early Detection of CKD May Delay Progression, Curb Healthcare Costs

Sep 20, 2021

CKD affects more than 37 million adults in the United States and drives nearly $120 billion in Medicare costs annually. Understanding the interplay between CKD detection, disease progression, and heal...

Clinical features of autosomal recessive polycystic kidney disease in the Japanese population and analysis of splicing in PKHD1 gene for determination of phenotypes.

Sep 20, 2021

Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1 gene. The clinical spectrum is often more variable than previously considered. We aimed to analyze the clinica...

NIHSS 24 h After Mechanical Thrombectomy Predicts 90-Day Functional Outcome.

Aug 19, 2021

Mechanical thrombectomy (MT) for large vessel occlusion (LVO) ischemic stroke is a safe and effective treatment modality. The National Institute of Health Stroke Scale (NIHSS) 24 h after MT (24 h...