Very Early Treatment in MS Provides “Spectacular” Improvement in Outcomes
Treatment for MS within 6 months of the first demyelinating event improved EDSS scores, disability progression, and conversion to secondary progressive MS....
Multiple Sclerosis
Authoritative medical articles, news, research, and guidelines pertaining to Multiple Sclerosis.
The role of C5a receptors in autoimmunity.
The complement system is an essential component of the innate immune response and plays a vital role in host defense and inflammation. Dysregulation of the complement system, particularly in...
Navigating the landscape of Rho GTPase signalling system in autoimmunity: A bibliometric analysis spanning over three decades (1990 to 2023).
Ras-homologous (Rho) guanosine triphosphatases (GTPases) are considered a central player in regulating various biological processes, extending to immune regulation. Perturbations in Rho GTPa...
Methylglyoxal suppresses microglia inflammatory response through NRF2-IκBζ pathway.
Methylglyoxal (MGO) is a highly reactive metabolite generated by glycolysis. Although abnormal accumulation of MGO has been reported in several autoimmune diseases such as multiple sclerosis...
NLRX1: versatile functions of a mitochondrial NLR protein that controls mitophagy.
NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting condition...
Co-Occurrence of MRI Markers May Predict Clinical Disability in MS
The joint occurrence of SELs and PRLs, two MRI markers of chronic active lesions in MS, was linked to greater clinical progression in patients with MS. Approximately 15% to 30% of the...
TSPO PET brain inflammation imaging: A transdiagnostic systematic review and meta-analysis of 156 case-control studies.
The 18-kDa translocator protein (TSPO) is increasingly recognized as a molecular target for PET imaging of inflammatory responses in various central nervous system (CNS) disorders. However, ...
Clinical and Epidemiological Aspects of Late Onset Multiple Sclerosis in East-Azerbaijan, Iran; A Population-Based Study.
Late-onset multiple sclerosis (LOMS) is defined as symptoms initiating at an age above 50.This study aims to determine the clinical and epidemiological aspects of LOMS in East-Azerbaijan pro...
Disease-modifying therapies do not affect sleep quality or daytime sleepiness in a large Australian MS cohort.
Poor sleep is common in multiple sclerosis (MS) and may impact daily functioning. The extent to which disease-modifying therapies (DMTs) contribute to sleep outcomes is under-examined.To com...
Lipocalin-2 promotes adipose-macrophage interactions to shape peripheral and central inflammatory responses in experimental autoimmune encephalomyelitis.
Accumulating evidence suggests that dysfunctional adipose tissue (AT) plays a major role in the risk of developing multiple sclerosis (MS), the most common immune-mediated and demyelinating ...
Which Patients With MS Can Initially Be Treated With Platform DMT?
Outcomes are poor for relapsing-remitting MS patients receiving platform therapy (pDMT) as first treatment, but a younger subgroup may benefit from pDMT. In a real-world study of pa...
Withdrawing DMF in Early Pregnancy Does Not Increase MS Relapse Risk
Pausing DMF treatment in early pregnancy doesn't raise relapse risk, while restarting treatment within a month after delivery reduces postpartum relapses. Interrupting treatment wit...
Interferon-beta exposure in-utero and the risk of infections in early childhood.
Knowledge within the field of multiple sclerosis treatment during pregnancy is vital to ensure the most optimal clinical practice. Immunomodulatory treatment in pregnancy could in theory aff...
Effects of disease-modifying therapies on lipid parameters in patients with multiple sclerosis.
Cholesterol and lipids are essential components of nerve cells. Myelin synthesis and stabilization is a cholesterol-dependent process. It has been shown in several studies that high plasma c...
Serum levels of neurofilament light chains in pediatric multiple sclerosis: a systematic review and meta-analysis.
Multiple sclerosis is a neuro-inflammatory disease that affects adults and children and causes somatic and cognitive symptoms. Diagnosis after the first clinical symptoms is challenging, inv...
Leukocyte telomere length in women with multiple sclerosis: Comparison with healthy women during pregnancy and puerperium.
Several studies indicated leukocyte telomere length (LTL) as a biomarker of multiple sclerosis (MS) evolution. This study aimed to investigate LTL in women with multiple sclerosis (MS) compa...
Index of cardiac-electrophysiological balance in relapsing-remitting multiple sclerosis patients treated with fingolimod.
Fingolimod is indicated for the treatment of relapsing-remitting multiple sclerosis (RRMS) and also targets cardiovascular system due to receptors on cardiomyocytes. Results of previous stud...
Assessment of differential item functioning of the PHQ-9, HADS-D and PROMIS-depression scales in persons with and without multiple sclerosis.
We tested for the presence of differential item functioning (DIF) in commonly used measures of depressive symptoms, in people with multiple sclerosis (MS) versus people with a psychiatric di...
Carotenoids contribution in rapid diagnosis of multiple sclerosis by Raman spectroscopy.
Rapid and accurate diagnosis of any illness determines the success of treatment. The same applies to multiple sclerosis (MS), chronic, inflammatory, and neurodegenerative diseases (ND) of th...
Q&A: Planning Crucial to ‘Optimize’ Care of MS-Related Reproductive Issues
For patients with MS, the potential impact of disease-modifying therapies on fertility and maternal and fetal health makes pre-conception critical. The diagnosis of MS in young ad...
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