The Sleep Neurophysiology in Parkinson's Disease
Sleep disturbances are one of the most prevalent nonmotor symptoms of Parkinson's disease (PD). They can appear in the early stages of the disease and worsen as the disease progresses. Sleep...
Parkinson's Disease
Authoritative medical articles, news, research, and guidelines pertaining to Parkinson's Disease.
Phenotypic and Genetic Heterogeneity in X-Linked Parkinsonism
X-linked Parkinsonism is a rare inherited disorder that mainly affects males. It has been observed that the condition is also linked to other non-neurological signs. The most prevalent trait...
A multimodal Parkinson quantification by fusing eye and gait motion patterns, using covariance descriptors, from non-invasive computer vision.
Parkinson's disease (PD) is a motor neurodegenerative disease principally manifested by motor disabilities, such as postural instability, bradykinesia, tremor, and stiffness. In clinical pra...
The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: signalling pathway and novel therapeutic targets.
Parkinson's disease (PD) is a chronic, progressive neurodegenerative condition; characterized with the degeneration of the nigrostriatal dopaminergic pathway and neuroinflammation. During PD...
White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia.
White matter hyperintensities (WMHs) are commonly assumed to represent non-specific cerebrovascular disease comorbid to neurodegenerative processes, rather than playing a synergistic role. W...
Gradient biomimetic platforms for neurogenesis studies.
There is a need for the development of new cellular therapies for the treatment of many diseases, with the central nervous system (CNS) currently an area of specific focus. Due to the comple...
Increased foot strike variability during turning in Parkinson's disease patients with freezing of gait.
Turning is a common trigger for freezing episodes in patients with Parkinson's disease (PD). Freezing during turning can lead to falls and fractures and decreased quality of life.Does foot-s...
Multi-disciplinary Approach for Drug and Gene Delivery Systems to the Brain.
Drug delivery into the brain has for long been a huge challenge as the blood-brain barrier (BBB) offers great resistance to entry of foreign substances (with drugs inclusive) into the brain....
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
The family of kynurenine pathway (KP) metabolites includes compounds produced along two arms of the path and acting in clearly opposite ways. The equilibrium between neurotoxic kynurenines, ...
Cognition, motor symptoms, and glycolipid metabolism in Parkinson's disease with depressive symptoms.
Depressive symptoms and abnormal glycolipid metabolisms are common in patients with Parkinson's disease (PD), but their relationship has not been fully reported. It is not clear whether glyc...
Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways.
Taurine (Tau) is one of the most abundant amino acids in the brain and regulates physiological functions in the central nervous system, including anti-inflammatory effects. There is growing ...
Adherence to treatment in Parkinson's disease: A multicenter exploratory study with patients from six Latin American countries.
Adherence to treatment in Parkinson's disease (PD) is compromised due to the need for multiple therapies, comorbidities related to aging, and the complexity of therapeutic schemes. In the pr...
White matter changes in drug-naïve Parkinson's disease patients with impulse control & probable REM sleep behavior disorders.
According to epidemiological studies, Parkinson's disease (PD) patients with probable REM sleep behavior disorder (pRBD) are more prone to develop impulse control disorders (ICDs), which is ...
Increased functional connectivity in a population at risk of developing Parkinson's disease.
While the concept of prodromal Parkinson's disease (PD) is well established, reliable markers for the diagnosis of this disease stage are still lacking. We investigated the functional connec...
Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study.
Given the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson's disease (PD) is difficult. Our aims were to examine the plasma ...
Synaptotagmin-11 inhibits spontaneous neurotransmission through vti1a.
Recent work has revealed that spontaneous release plays critical roles in the central nervous system, but how it is regulated remains elusive. Here we report that synaptotagmin-11 (Syt11), a...
Using virtual reality to assess vestibulo-visual interaction in people with Parkinson's disease compared to healthy controls.
People with Parkinson's disease (PD) have increased visual dependency for balance and suspected vestibular dysfunction. Immersive virtual reality (VR) allows graded manipulation of visual se...
Convergent structural network and gene signatures for MRgFUS thalamotomy in patients with Parkinson's disease.
MRgFUS has just been made available for the 1.7 million Parkinson's disease patients in China. Despite its non-invasive and rapid therapeutic advantages for involuntary tremor, some concerns...
Brain functional specialization and cooperation in Parkinson's disease.
Cerebral specialization and inter-hemispheric cooperation are two of the most prominent functional architectures of the human brain. Their dysfunctions may be related to pathophysiological c...
Identification of EEG Dynamics during Freezing of Gait and Voluntary Stopping in Patients with Parkinson's Disease.
Mobility is severely impacted in patients with Parkinson's disease (PD), who often experience involuntary stopping from the freezing of gait (FOG). Understanding the neurophysiological diffe...
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