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STDs

HBV Promotes the Recruitment of IL-17 secreting T cells via Chemokines CCL22 and CCL17.

Mar 19, 2020

Little is known about the mechanisms of IL-17 secreting T cells accumulation in HBV-transfected livers. Here, we investigated the role of the chemokines CCL17, CCL20, and CCL22 in this process.Periphe...

Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.

Mar 13, 2020

In patients with HBV and HCV coinfection, HBV reactivation leading to severe hepatitis has been reported with the use of direct-acting antivirals (DAAs) to treat HCV infection. Here we study the molec...

Real world clinical practice in treating advanced hepatocellular carcinoma: When East meets West.

Mar 13, 2020

The Barcelona Clinic Liver Cancer (BCLC) stage C (BCLC C) of hepatocellular carcinoma (HCC) includes a heterogeneous population for which sorafeninb is one of the recommended therapies. We aim to eval...

De-intensification of therapy in human papillomavirus associated oropharyngeal cancer: A systematic review of prospective trials.

Mar 13, 2020

Numerous trials have been launched over the prior decade examining the safety and efficacy of therapy de-escalation in human papillomavirus (HPV)-associated oropharyngeal cancer (OPC). Because no summ...

Circulating CTLA-4 levels and CTLA4 polymorphisms associate with disease condition and progression and hepatocellular carcinoma patients' survival in chronic hepatitis B virus infection.

Mar 13, 2020

CTLA-4 is involved in the immune dysfunction of hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study analyzed the association of circulating CTLA-4 levels and CTLA4 polymor...

Phenotypic testing of patient herpes simplex virus type 1 and 2 isolates for acyclovir resistance by a novel method based on real-time cell analysis.

Mar 13, 2020

Acyclovir (ACV) is the most commonly used drug for herpes simplex virus (HSV) infection therapy. Prolonged antiviral therapy or prophylaxis in immunocompromised patients may promote the development of...

A cross-sectional study on dental surgeons' immune status against hepatitis B virus in the Public Health System.

Mar 05, 2020

Hepatitis B is a severe public health problem. The main world health centers have discussed it due to its pandemic proportion, high pathogenicity and infectivity. This study aimed to determine the imm...

Who Is Scared of a Needle? An Exploration of Italian Children's Knowledge and Perceptions About the HPV Vaccine.

Mar 05, 2020

Receiving the HPV vaccine at a young age before being exposed to the virus is essential to improve HPV-related cancer prevention. In many countries in the world, like Italy, the HPV vaccine is offered...

Efficacy of oral antiviral drugs to prevent mother-to-child transmission of hepatitis B virus: a network meta-analysis.

Mar 05, 2020

Hepatitis B is a serious global health problem. Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is a major risk factor in the endemicity of HBV infection. Oral antiviral drugs are recom...

Virus-Mediated Suppression of the Antigen Presentation Molecule MR1.

Mar 05, 2020

The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells). Although bacteria and fungi drive the MR1 ...

Comparative proteomic analyses of the liver in D-galactosamine-sensitized mice treated with different Toll-like receptor agonists.

Mar 05, 2020

Acute liver failure (ALF) is a severe consequence of abrupt hepatocyte injury and has lethal outcomes. Three Toll-like receptor (TLR) agonists, including polyinosinic-polycytidylic acid [poly(I:C)], l...

Evaluation of Renal Disease in Patients With Cirrhosis.

Feb 25, 2020

Renal dysfunction in cirrhosis is common and is associated with increased mortality. Identifying and treating reversible causes of renal disease can significantly improve outcomes. The etiology, appro...

Evaluation of durability of a single-dose of the bivalent HPV vaccine: the CVT Trial.

Feb 25, 2020

Investigate the durability of vaccine efficacy (VE) against HPV16/18 infections and antibody response among non-randomized women who received a single-dose of the bivalent HPV vaccine compared to wome...

Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: the CVT Trial.

Feb 25, 2020

The Costa Rica HPV Vaccine Trial (CVT) has documented cross-protection of the bivalent HPV vaccine against HPV31/33/45 up to seven years after vaccination, even with one dose of the vaccine. However, ...

Virus-associated anterior uveitis and secondary glaucoma: Diagnostics, clinical characteristics, and surgical options.

Feb 25, 2020

In this retrospective, single-center, observational study, we compared the clinical characteristics, analyzed the glaucoma development, and the glaucoma surgery requirement mediators in patients with ...

Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis.

Feb 25, 2020

We evaluated the efficacy and safety of upadacitinib, an oral selective inhibitor of Janus kinase 1, as induction therapy for ulcerative colitis (UC).We performed a multicenter, double-blind, phase 2b...

Functional epitopes on hepatitis E virions and recombinant capsids are highly conformation-dependent.

Jan 30, 2020

Hepatitis E virus (HEV) is responsible for epidemic and sporadic acute hepatitis cases, especially in developing countries. Hepatitis E has become a vaccine-preventable disease in recent years with th...

Cost Comparison Between 2 Responses to Hepatitis A Virus Incidents in Restaurant Food Handlers-New York City, 2015 and 2017.

Jan 30, 2020

While the New York City Department of Health and Mental Hygiene (DOHMH) can use agency-wide emergency activation to respond to a hepatitis A virus-infected food handler, there is a need to identify al...

Implementation of Australia's renewed cervical screening program: Preparedness of general practitioners and nurses.

Jan 30, 2020

The National Cervical Screening Program (NCSP) in Australia underwent major changes on December 1st, 2017. The program changed from 2-yearly Pap testing for women aged 18-69 years to 5-yearly HPV test...

A Kinesin-3 recruitment complex facilitates axonal sorting of enveloped alpha herpesvirus capsids.

Jan 30, 2020

Axonal sorting, the controlled passage of specific cargoes from the cell soma into the axon compartment, is critical for establishing and maintaining the polarity of mature neurons. To delineate axona...