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Brain Cancer Oncology

Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition.

Mar 05, 2020

Malignant glioma is a lethal brain tumor that is highly resistant to standard therapy. Our research aims to explore the suppressive effects of nitidine chloride (NC) on gliomas and the mechanisms inv...

CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents.

Mar 02, 2020

Medulloblastoma (MB) is the most common malignant brain tumor in children, and it is classified into four biological subgroups: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. The current treatment is...

Blood-brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors.

Mar 02, 2020

Opening of the blood-brain barrier (BBB) by pulsed low intensity ultrasound has been developed during the last decade and is now recognized as a safe technique to transiently and repeatedly open the B...

Optimizing 3D EPI for rapid T -weighted imaging.

Mar 02, 2020

To investigate the use of 3D EPI for rapid T -weighted brain imaging, focusing on the RF pulse's influence on the contrast between gray and white matter.An interleaved 3D EPI sequence use partial Four...

Intracranial glioma xenograft model rapidly reestablishes blood-brain barrier integrity for longitudinal imaging of tumor progression using fluorescence molecular tomography and contrast agents.

Mar 02, 2020

The blood-brain barrier (BBB) is a major obstacle to detecting and treating brain tumors. Overcoming this challenge will facilitate the early and accurate detection of brain lesions and guide surgical...

Autophagy inhibition changes the disposition of non-viral gene carriers during blood-brain barrier penetration and enhances TRAIL-induced apoptosis in brain metastatic tumor.

Mar 02, 2020

Non-viral gene delivery systems have proven to be a promising approach in the treatment of brain metastatic cancers but facing delivery difficulties. Due to the existence of blood-brain barrier, non-v...

Dual-targeting and excretable ultrasmall SPIONs for T-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein.

Feb 28, 2020

A precise delineation of the intracranial glioblastoma boundary is urgently required for pre-surgical operations, due to the tumor-inherent infiltrative character of a tumor and the difficulty to comp...

Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells.

Feb 28, 2020

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor and is associated with extensive tumor cell infiltration into the adjacent brain parenchyma. However, there are limited targeted ...

Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333.

Feb 28, 2020

Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive, early-childhood brain tumor without standard effective treatment. To our knowledge, we conducted the first AT/RT-specific cooperative group t...

Medulloblastoma: Molecular understanding, treatment evolution, and new developments.

Feb 28, 2020

Medulloblastoma (MB) is the most common childhood malignant brain tumor, accounting for approximately 20% of all pediatric central nervous system tumors. Current standard treatments involving surgical...

Lipid Peroxidation Plays an Important Role in Chemotherapeutic Effects of Temozolomide and the Development of Therapy Resistance in Human Glioblastoma.

Feb 25, 2020

Glioblastoma (GBM) is the most malignant primary brain tumor. Relapse occurs regularly, and the clinical behavior seems to be due to a therapy-resistant subpopulation of glioma-initiating cells that b...

Synchrotron X-ray boost delivered by Microbeam Radiation Therapy after conventional X-ray therapy fractionated in time improves F98 glioma control.

Feb 25, 2020

Synchrotron microbeam radiation therapy (MRT) is based on the spatial fractionation of the incident, highly collimated synchrotron beam into arrays of parallel microbeams depositing several hundred gr...

Measure thrice, cut twice: On the benefit of reoperation for failed pediatric epilepsy surgery.

Feb 25, 2020

To determine whether clinical outcomes are improved after repeat surgery for medically refractory epilepsy in children.This is a single-center retrospective cohort analysis of all patients who receive...

Automatic segmentation of brain tumor resections in intraoperative ultrasound images using U-Net.

Feb 25, 2020

To compensate for the intraoperative brain tissue deformation, computer-assisted intervention methods have been used to register preoperative magnetic resonance images with intraoperative images. In o...

Dexmedetomidine as adjunct in awake craniotomy - improvement or not?

Feb 25, 2020

Over the last decade, awake craniotomy for tumor resection has become a standard to maximize tumor resection and minimize the risk of permanent neurological deficits. Different techniques and medicati...