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Brain Cancer Oncology

PT109, a novel multi-kinase inhibitor, suppresses glioblastoma multiforme through cell reprogramming: Involvement of PTBP1/PKM1/2 pathway.

Feb 28, 2022

Glioblastoma multiforme (GBM) is the most prevalent type and lethal form of primary malignant brain tumor, accounting for about 40-50% of intracranial tumors and without effective treatments now. Cell...

Impaired cognitive control in patients with brain tumors.

Feb 28, 2022

Though the assessment of cognitive functions is proven to be a reliable prognostic indicator in patients with brain tumors, some of these functions, such as cognitive control, are still rarely investi...

Primary central nervous system sarcomas in adults: A systematic review.

Feb 14, 2022

Primary central nervous system (CNS) sarcomas represent a heterogeneous group of rare neoplasms with unclear etiology. Available data on clinical characteristics, treatment strategies, and survival ar...

Socioeconomic factors affecting survivorship of glioblastoma patients in the Philippines.

Feb 14, 2022

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults worldwide. However, data on the survivorship of GBM patients in low- and middle-income countries is sparse. We determined ...

Solitary pulmonary metastasis after meningioma surgery of the head: a case report.

Feb 07, 2022

Meningioma is the most common type of benign primary brain tumor that is rarely associated with distant metastasis. No established treatment strategy for metastatic meningiomas exists to date. Herein,...

Application of Intraoperative Contrast-Enhanced Ultrasound in the Resection of Brain Tumors.

Feb 07, 2022

To investigate the value of routine intraoperative ultrasound (IU) and intraoperative contrast-enhanced ultrasound (ICEUS) in the surgical treatment of brain tumors, and to explore the utilization of ...

A Rare Case of Glioblastoma With Extensive Liver Metastases.

Jan 31, 2022

Glioblastoma (GBM), the most common primary brain tumor, is a highly aggressive malignancy for which the median survival is about 13 months, and 5-year survival is well under 5%. These tumors usually ...

A novel promoter-associated non-coding small RNA paGLI1 recruits FUS/P65 to transactivate GLI1 gene expression and promotes infiltrating glioma progression.

Jan 24, 2022

Glioma-associated oncogene homolog 1 (GLI1) is a core component of the Hedgehog (HH) signalling pathway and is a transcription activator of numerous oncogenes, such as SOX9, VEGFA, BCL2, and CDK2. The...

Neurological outcomes following awake and asleep craniotomies with motor mapping for eloquent tumor resection.

Jan 24, 2022

Cortical mapping has been used as a tool to ensure maximal safe resection of intracranial tumors for several decades. Post-surgical motor and language deficits, including seizures, weakness, aphasia, ...

NEK2 enhances malignancies of glioblastoma via NIK/NF-κB pathway.

Jan 17, 2022

Glioblastoma (GBM) is one of the most lethal primary brain tumor with a poor median survival less than 15 months. Despite the development of the clinical strategies over the decades, the outcomes for ...

Establishing a standardized method for the effective intraoperative collection and biological preservation of brain tumor tissue samples using a novel tissue preservation system: A pilot study.

Jan 17, 2022

Glioblastoma (GB) is an aggressive tumor exhibiting extensive inter- and intratumoral heterogeneity. Several possible reasons contribute to the historical inability to develop effective therapeutic st...

Targeting immunoliposomes to EGFR-positive glioblastoma.

Jan 10, 2022

We assessed the capacity of epidermal growth factor receptor (EGFR)-targeted immunoliposomes to deliver cargo to brain tumor tissue in patients with relapsed glioblastoma harboring an EGFR amplificati...

SHMT1 siRNA-Loaded hyperosmotic nanochains for blood-brain/tumor barrier post-transmigration therapy.

Jan 10, 2022

The near-perivascular accumulation in solid tumors and short-lived span in circulation, derails even the most competent nanoparticles (NPs) from achieving their maximum therapeutic potential. Moreover...

Live-Cell Synchrotron-Based FTIR Evaluation of Metabolic Compounds in Brain Glioblastoma Cell Lines after Riluzole Treatment.

Jan 03, 2022

Glioblastoma multiforme (GBM) is the most aggressive brain tumor, characterized by short median survival and an almost 100% tumor-related mortality. The standard of care treatment for newly diagnosed ...

Non-invasive mapping of cortical categorization function by repetitive navigated transcranial magnetic stimulation.

Jan 03, 2022

Over the past years navigated repetitive transcranial magnetic stimulation (nrTMS) had become increasingly important for the preoperative examination and mapping of eloquent brain areas. Among other a...

Cross-modal distillation to improve MRI-based brain tumor segmentation with missing MRI sequences.

Dec 27, 2021

Convolutional neural networks (CNNs) for brain tumor segmentation are generally developed using complete sets of magnetic resonance imaging (MRI) sequences for both training and inference. As such, th...

L-Ascorbic Acid and Curcumin prevents Brain Damage-induced via Lead Acetate in Rats: Possible Mechanisms.

Dec 27, 2021

Lead acetate (lead ac.) is a widespread ecological toxicant that can cause marked neurotoxicity and decline in brain functions. This study aimed to evaluate the possible neuroprotective role of L-asco...

Advancements of MRI-Based Brain Tumor Segmentation from Traditional to Recent Trends- A Review.

Dec 20, 2021

Among the brain-related diseases, brain tumor segmentation on magnetic resonance imaging (MRI) scans is one of the highly focused research domains in the medical community. Brain tumor segmentation is...

Automated Detection of Brain Tumor through Magnetic Resonance Images Using Convolutional Neural Network.

Dec 20, 2021

Brain tumor is a fatal disease, caused by the growth of abnormal cells in the brain tissues. Therefore, early and accurate detection of this disease can save patient's life. This paper proposes a nove...

The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion.

Dec 06, 2021

Bromodomain and extraterminal domain (BET) proteins have emerged as therapeutic targets in multiple cancers, including the most common primary adult brain tumor glioblastoma (GBM). Although several BE...