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Brain Cancer Oncology

BCL7A as a novel prognostic biomarker for glioma patients.

Aug 09, 2021

Glioma is the most common primary brain tumor and represents one of the most aggressive and lethal types of human cancer. BCL7 family has been found in several cancer types and could be involved in tu...

Identification of pimavanserin tartrate as a potent Ca-calcineurin-NFAT pathway inhibitor for glioblastoma therapy.

Aug 09, 2021

Glioblastoma multiforme (GBM) is the most common and malignant type of primary brain tumor, and 95% of patients die within 2 years after diagnosis. In this study, aiming to overcome chemoresistance to...

Gliomagenesis is orchestrated by the Oct3/4 regulatory network.

Aug 05, 2021

Glioblastoma multiforme (GBM) is a lethal brain tumor characterized by developmental hierarchical phenotypic heterogeneity, therapy resistance and recurrent growth. Neural stem cells (NSCs) from human...

Clinical characteristics and MRI-based prediction of the KLF4-mutation in meningioma.

Aug 05, 2021

Meningioma is the most common primary brain tumor in adults. In recent years, several non-NF2 mutations, i.e. AKT1, SMO, TRAF7, and KLF4 mutations, specific for meningioma have been identified. This s...

Cerebral Macro- and Microcirculation during Ephedrine versus Phenylephrine Treatment in Anesthetized Brain Tumor Patients: A Randomized Clinical Trial Using Magnetic Resonance Imaging.

Aug 05, 2021

This study compared ephedrine versus phenylephrine treatment on cerebral macro- and microcirculation, measured by cerebral blood flow, and capillary transit time heterogeneity, in anesthetized brain t...

Trends in physician reimbursements and procedural volumes for radiosurgery versus open surgery in brain tumor care: an analysis of Medicare data from 2009 to 2018.

Aug 02, 2021

Given its minimally invasive nature and effectiveness, stereotactic radiosurgery (SRS) has become a mainstay for the multimodal treatment of intracranial neoplasm. However, no studies have evaluated r...

Learning rich features with hybrid loss for brain tumor segmentation.

Aug 02, 2021

Accurately segment the tumor region of MRI images is important for brain tumor diagnosis and radiotherapy planning. At present, manual segmentation is wildly adopted in clinical and there is a strong ...

The "Three on a Stick" Incision-A Curvilinear Solution for the Occipital and Suboccipital Region.

Aug 02, 2021

Different conditions of the posterior fossa such as Chiari malformations, tumors, and arachnoid cysts require surgery through a suboccipital approach, for which a typical midline vertical linear incis...

Classification of glioblastoma versus primary central nervous system lymphoma using convolutional neural networks.

Jul 29, 2021

A subset of primary central nervous system lymphomas (PCNSL) are difficult to distinguish from glioblastoma multiforme (GBM) on magnetic resonance imaging (MRI). We developed a convolutional neural ne...

Face Processing and Social Functioning in Pediatric Brain Tumor Survivors.

Jul 29, 2021

Pediatric brain tumor survivors (PBTS) experience deficits in social functioning. Facial expression and identity recognition are key components of social information processing and are widely studied ...

An integrative histopathological and epigenetic characterization of primary intracranial mesenchymal tumors, FET:CREB-fused broadening the spectrum of tumor entities in comparison with their soft tissue counterparts.

Jul 29, 2021

FET:CREB fusions have been described in a variety of tumors from various phenotypes. Recently, these fusion transcripts were reported in intracranial tumors, variably named intracranial mesenchymal my...

Simpson Grade I Resection of Type II Clinoidal Meningiomal Through Cranio-orbital Zygomatic Approach: 2-Dimensional Operative Video.

Jul 26, 2021

Clinoidal meningiomas have been considered as a separate entity with distinguishing clinical, radiological, and surgical considerations.1-2 Surgical mortality and morbidity associated with anterior cl...

The predictive value of segmentation metrics on dosimetry in organs at risk of the brain.

Jul 26, 2021

Fully automatic medical image segmentation has been a long pursuit in radiotherapy (RT). Recent developments involving deep learning show promising results yielding consistent and time efficient conto...

Role of deep learning in brain tumor detection and classification (2015 to 2020): A review.

Jul 26, 2021

During the last decade, computer vision and machine learning have revolutionized the world in every way possible. Deep Learning is a sub field of machine learning that has shown remarkable results in ...

Metabolic Drivers of Invasion in Glioblastoma.

Jul 22, 2021

Glioblastoma is a primary malignant brain tumor with a median survival under 2 years. The poor prognosis glioblastoma caries is largely due to cellular invasion, which enables escape from resection, a...

CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models.

Jul 22, 2021

Glioblastoma (GBM) is a devastating primary brain tumor with a highly immunosuppressive tumor microenvironment, and treatment with oncolytic viruses (OVs) has emerged as a promising strategy for these...

Long-term migratory velocity measurements of single glioma cells using microfluidics.

Jul 22, 2021

Microfluidic platforms enabling single-cell measurements notably contribute to the identification and observation of rare cancer cells that are involved in tumor invasion. Most aggressive, invasive, a...

Altered Expression of miR-575 in Glioma is Related to Tumor Cell Proliferation, Migration, and Invasion.

Jul 19, 2021

Glioma is a kind of brain tumor with low overall survival and treatment success rates in the advanced stage. Evidence has shown microRNA-575 (miR-575) plays an important role in the generation and dev...

Lipidomic analysis and diagnosis of glioblastoma multiforme with rapid evaporative ionization mass spectrometry.

Jul 19, 2021

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor in the central nervous system. GBM patients have a very low five-year survival rate and most of them died within one year. C...

B-Map: a fuzzy-based model to detect foreign objects in a brain.

Jul 19, 2021

To cope up with the medical complications, scientists and physicians rely more on digitized historical evidence. It helps them to identify the disease and to develop new drugs and strategies. The auth...