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Brain Cancer Oncology

Lipidomic analysis and diagnosis of glioblastoma multiforme with rapid evaporative ionization mass spectrometry.

Jul 19, 2021

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor in the central nervous system. GBM patients have a very low five-year survival rate and most of them died within one year. C...

B-Map: a fuzzy-based model to detect foreign objects in a brain.

Jul 19, 2021

To cope up with the medical complications, scientists and physicians rely more on digitized historical evidence. It helps them to identify the disease and to develop new drugs and strategies. The auth...

Characterization of systemic immunosuppression by IDH mutant glioma small extracellular vesicles.

Jul 15, 2021

Gliomas are the most common primary brain tumors and are universally fatal. Mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) define a distinct glioma subtype associated with an immunosu...

Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse.

Jul 15, 2021

Astrocytes, a major glial cell type in the brain, play a critical role in supporting the progression of medulloblastoma (MB), the most common malignant pediatric brain tumor. Through lineage tracing a...

Intellectual functioning among case-matched cohorts of children treated with proton or photon radiation for standard-risk medulloblastoma.

Jul 15, 2021

Proton therapy may reduce cognitive deficits after radiotherapy among brain tumor survivors, although current data are limited to retrospective comparisons between historical cohorts. The authors comp...

MiR-200c-based metabolic modulation in glioblastoma cells as a strategy to overcome tumor chemoresistance.

Jul 12, 2021

Glioblastoma (GB) is the most aggressive and common form of primary brain tumor characterized by fast proliferation, high invasion, and resistance to current standard treatment. The average survival r...

EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG.

Jul 12, 2021

ONC201/TIC10 activates TRAIL signaling through ATF4 and the integrated stress response (ISR). ONC201 demonstrated tumor regressions and disease stability in patients with histone H3K27M-mutated midlin...

In vivo liquid biopsy for glioblastoma malignancy by the AFM and LSPR based sensing of exosomal CD44 and CD133 in a mouse model.

Jul 12, 2021

Glioblastoma (GBM) is the fatal brain tumor in which secreted lactate enhances the expression of cluster of differentiation 44 (CD44) and the release of exosomes, cell-derived nanovesicles (30-200 nm...

Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing.

Jul 08, 2021

Glioblastoma is the most aggressive type of brain tumor with poor therapeutic response and prognosis. Passage of systemically delivered pharmacological agents into the brain is largely blocked by the ...

Neuropsychiatric symptoms following brain tumor resection in children and adolescents: a scoping review.

Jul 08, 2021

Brain tumors are one of the most common solid tumors in pediatric populations, with their treatments having significant neuropsychiatric impact.To review the literature on neuropsychiatric sequelae af...

Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.

Jul 08, 2021

The abilities to invade surrounding tissues and metastasize to distant organs are the most outstanding features that distinguish malignant from benign tumors. However, the mechanisms preventing the in...

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.

Jul 05, 2021

Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in children. In vitro and in vivo disease models reflecting the intimate connection between developmental context and ...

Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients.

Jul 05, 2021

High-grade meningioma is an aggressive type of brain cancer that is often recalcitrant to surgery and radiotherapy, leading to poor overall survival. Currently, there are no FDA-approved drugs for men...

Rapid tumor recurrence in a novel murine GBM surgical model is associated with Akt/PD-L1/vimentin signaling.

Jul 05, 2021

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even...

An efficient brain tumor image classifier by combining multi-pathway cascaded deep neural network and handcrafted features in MR images.

Jul 01, 2021

Accurate segmentation and delineation of the sub-tumor regions are very challenging tasks due to the nature of the tumor. Traditionally, convolutional neural networks (CNNs) have succeeded in achievin...

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.

Jul 01, 2021

The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the classification of brain and spi...

A novel radiographic marker of sarcopenia with prognostic value in glioblastoma.

Jul 01, 2021

Sarcopenia is an important prognostic consideration in surgical oncology that has received relatively little attention in brain tumor patients. Temporal muscle thickness (TMT) has recently been propos...

Spatiotemporal Flexible Sparse Reconstruction for Rapid Dynamic Contrast-enhanced MRI.

Jun 28, 2021

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a tissue perfusion imaging technique. Some versatile free-breathing DCE-MRI techniques combining compressed sensing (CS) and parallel ...

Microphysiological systems to study tumor-stroma interactions in brain cancer.

Jun 28, 2021

Brain tumors still lack effective treatments, and the mechanisms of tumor progression and therapeutic resistance are unclear. Multiple parameters affect cancer prognosis (e.g., type and grade, age, lo...

Quality of YouTube videos on meningioma treatment using the DISCERN instrument.

Jun 28, 2021

To assess the quality of YouTube videos on meningioma treatment.A search was performed on YouTube using the keywords "meningioma treatment", "meningeal tumor treatment", "meningioma brain tumor treatm...