BRCA2 Pathogenic Variants Linked to Secondary Cancers
In triple-negative breast cancer, patients with BRCA2 pathogenic variants had higher frequencies of bone and CNS metastases....
In triple-negative breast cancer, patients with BRCA2 pathogenic variants had higher frequencies of bone and CNS metastases....
In survivors of breast cancer, the influence of chronic pain on QOL persisted even after controlling for concurrent pain. Chronic pain remains highly prevalent among survivors o...
Other breast cancer risk factors in addition to breast density should be considered when deciding whether to prescribe supplemental ultrasound screening....
Mammography AI scores, along with traditional risk factors, can potentially identify up to 60% of women at higher risk for breast cancer. Breast cancer is the second leading cau...
Patients with the strongest versus weakest adherence to the cancer prevention lifestyle recommendations experienced a 58% reduction in mortality. “Although the American Instit...
Adding ribociclib to endocrine therapy improved invasive and distant disease-free survival of patients with early-stage HR-positive/HER2-negative breast cancer. Most breast cancers ar...
First-line CDK4/6 inhibition did not boost survival or QOL but did prolong CDK4/6 inhibitor use and increased grade 3-4 toxicity and drug costs. CDK4/6 inhibitors improve the outcome ...
The GeparNuevo trial sheds light on the role of RNA expression from peripheral immune cells in predicting treatment outcomes. The phase 2 GeparNuevo trial (NCT02685059) has demonstra...
Studies have suggested that screening for a given type of cancer could be used to promote participation in other types. Specifically, breast cancer (BC) screening tends to have a higher part...
Click to read this study in The Lancet Oncology....
Click to read this study in The Lancet Oncology....
Click to read this study in JAMA Network Open. ...
A single assessment of the circulating tumor cells (CTC) count before treatment can guide the treatment decision between chemotherapy and single-agent endocrine therapy in ER-positive/HER2-n...
In vitro studies using DNA barcoded cell lines demonstrated that resistance to CDK4/6 inhibitors is likely due to the expansion of pre-existing resistant clones, suggesting that targeting re...
Among patients with HR-positive/HER2-negative metastatic breast cancer, combining palbociclib with fulvestrant beyond progression on prior CDK4/6 inhibition did not significantly improve pro...
Duration of first-line CDK4/6 inhibitor therapy in patients with ER-positive/HER2-negative metastatic breast cancer is associated with duration of progression-free survival (PFS) of subseque...
Compared with capecitabine-based regimens, trastuzumab deruxtecan (T-DXd) led to higher response rates and longer survival in the third-line setting for patients with HER2-positive metastati...
In women carrying a germline pathogenic variant for breast cancer, like BRCA1, BRCA2, or CHEK2, the risk for contralateral breast cancer is also increased, data from a sub-analysis of the CA...
Paclitaxel/cemiplimab/fianlimab is a highly effective combination for neoadjuvant therapy in both triple-negative breast cancer (TNBC) and HR-positive/HER2-negative breast cancer. In additio...
Patients with breast cancer who pause their endocrine therapy to try to get pregnant experienced short-term rates of breast cancer recurrence similar to women who do not pause therapy for pr...
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