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Oncology / Hematology

Mucosal Melanoma Patients Treated with Atezolizumab and Bevacizumab

Nov 25, 2022

Anti–programmed cell death-1 monotherapy is a typical treatment for cutaneous melanoma, although it is ineffective against mucosal melanoma. Researchers assessed the efficacy and safety of atezolizu...

CT900 is a Folate Receptor–mediated Thymidylate Synthase Inhibitor in Solid Tumor Patients

Nov 25, 2022

This research was conducted because CT900 is a novel small molecule thymidylate synthase inhibitor that specifically binds to the α-folate receptor (α-FR), making it available for uptake only by mal...

Belantamab Mafodotin for Relapsed/Refractory Multiple Myeloma

Nov 24, 2022

The Food and Drug Administration (FDA) granted accelerated approval to the drug belantamab mafodotin-blmf (BLENREP; GlaxoSmithKline) on August 5, 2020, for the treatment of adult patients with relapse...

BRAF in Cancer Therapy: Molecular Mechanisms and Pathways

Nov 24, 2022

Because BRAF activating mutations have been found in so many different types of cancer, there has been a concerted push to develop BRAF-specific therapies that are both safe and effective. As a result...

Pancreatic Cancer Immunotherapy: What We Know and What We Hope for

Nov 24, 2022

In spite of recent advances, pancreatic ductal adenocarcinoma (PDAC) is still extremely difficult to cure. Unfortunately, the benefits of chemotherapy for patients with advanced and metastatic cancer ...

Adherence to Quality Indicators Low in Chronic Myeloid Leukemia

Nov 23, 2022

WEDNESDAY, Nov. 23, 2022 (HealthDay News) -- For newly diagnosed chronic-phase chronic myeloid leukemia (CML) patients, adherence to guideline-based quality indicators is low, according to a study pub...

Adults Lack Knowledge About Signs of Pancreatic Cancer

Nov 23, 2022

TUESDAY, Nov. 22, 2022 (HealthDay News) -- Most adults (83 percent) are unaware of the signs or symptoms of pancreatic cancer, according to the results of a survey released by the Pancreatic Cancer Ac...

Decrease Noted in Lung Cancer Cases Over Past Five Years

Nov 23, 2022

TUESDAY, Nov. 22, 2022 (HealthDay News) -- The number of new cases of lung cancer decreased over the last five years, but screening rates are still low, according to a report published by the American...

Total Laryngectomy Associated With Negative QOL

Nov 23, 2022

Olfactory dysfunction following total laryngectomy decreased QOL for patients, especially among individuals who reported smoking. Total laryngectomy (TL) is associated with olfactory dysfunctio...

Contribution of Neutrophil Extracellular Traps in Liver Damage and Increased Defective LDNs in Alcoholic Hepatitis

Nov 23, 2022

Poor clinical outcomes in alcoholic hepatitis (AH) were correlated with inflammation and neutrophil levels. For a study, researchers sought to determine how neutrophils affected AH liver injury. In...

Hepatocellular Carcinoma Screening in Blood-Based Biomarkers

Nov 23, 2022

Worldwide, hepatocellular carcinoma (HCC) is the most common cancer-related cause of death, in part due to the lack of effective early detection methods. According to current guidelines, screening for...

Oncogenic Variants Identified in ~10 Percent With Appendix Cancer

Nov 22, 2022

TUESDAY, Nov. 22, 2022 (HealthDay News) -- About 10 percent of patients with appendix cancer (AC) who undergo testing for hereditary cancer disposition harbor a gene sequence variation associated with...

Significant Treatment Attrition Rate Seen in Multiple Myeloma

Nov 22, 2022

TUESDAY, Nov. 22, 2022 (HealthDay News) -- There is a significant treatment attrition rate in newly diagnosed multiple myeloma (NDMM), according to a study published in the November issue of Leukemia ...

Most Pivotal Trials of New Drugs Recruit From Low-, Middle-Income Countries

Nov 22, 2022

MONDAY, Nov. 21, 2022 (HealthDay News) -- Most pivotal trials of new cancer, cardiovascular, and neurologic drugs recruit from low- and middle-income countries (LMIC), according to a study published o...

Acute Back Pain Following Clostridium Histolyticum Collagenase Intralesional Injection for Peyronie's Disease

Nov 22, 2022

Post-injection acute lower back discomfort has been added to the list of potential side effects associated with intralesional therapy for Peyronie's disease after it was noted in a study with collagen...

OnabotulinumtoxinA Intravesical Instillation in the Refractory OAB Treatment of Urinary Incontinence Patients

Nov 22, 2022

OnabotulinumtoxinA intradetrusor injections effectively treat overactive bladder and urgency incontinence in individuals who have not responded to or are intolerant of anticholinergics. Less frequent ...

Higher doses of vitamin K at birth may decrease vitamin K deficiency in very preterm infants

Nov 21, 2022

1. In a randomized controlled trial comparing prophylactic vitamin K doses in 75 very preterm or very low birthweight infants, those receiving 1 mg intramuscular vitamin K at birth had significantly l...

Treatment Without ADT Delays Initiation of Systemic Therapy in Prostate Cancer

Nov 21, 2022

MONDAY, Nov. 21, 2022 (HealthDay News) -- For prostate cancer patients with a solitary oligometastatic lesion, metastasis-directed therapy without androgen deprivation therapy (ADT) can delay initiati...

Treatment-Related Adverse Events of Antibody Drug Conjugates Identified

Nov 21, 2022

MONDAY, Nov. 21, 2022 (HealthDay News) -- Adverse effects associated with antibody-drug conjugates (ADCs) have been described in a review and meta-analysis published online Nov. 21 in Cancer.Youwen Zh...

The Objective Response & Overall Survival in Advanced Unresectable Hepatocellular Carcinoma

Nov 21, 2022

Overall survival (OS) validated surrogate endpoints are crucial for accelerating the clinical trial and medication development processes. For a study, researchers sought to confirm objective response ...