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Oncology / Hematology

Immunocompromised Patients With Blood Cancer Benefit from Third COVID-19 Vaccine

Nov 16, 2022

When three-dose schedule antibody concentrations are reached in patients with blood cancer who are immunocompromised, they are comparable to that of healthy controls after two doses. Patients w...

FDA Approves Drug Combo for Metastatic Non-Small Cell Lung Cancer

Nov 15, 2022

TUESDAY, Nov. 15, 2022 (HealthDay News) -- The U.S. Food and Drug Administration approved the combination of tremelimumab (Imjudo) plus durvalumab (Imfinzi) and platinum-based chemotherapy for adult p...

Transcriptional Signature of TP53 Biallelic Inactivation Identifies a Group of MM Patients Without this Genetic Condition but with Dismal Outcome

Nov 15, 2022

The prognosis for double-hit (DH) multiple myeloma (MM), which has a dire prognosis, is made worse by the inclusion of biallelic inactivation of TP53 in the description of the disease. The 15%–20% o...

The ODCs is Generally Left-shifted in COVID-19 Patients at Admission to Hospital, and Associated with Lower Mortality

Nov 15, 2022

A significant amount of arterial hypoxia and hypocapnia are brought on by SARS-Cov-2 virus-induced lung injury. If these circumstances caused a change in the affinity of hemoglobin for oxygen, the lit...

Early Cardiac Response is Possible in Stage IIIb Cardiac AL Amyloidosis & Linked with Prolonged Survival

Nov 15, 2022

Despite the development of innovative therapies, patients with immunoglobulin light chain (AL) amyloidosis and stage IIIb cardiac involvement have a poor prognosis. However, higher survival results fr...

CD48 a Likely Biomarker in NK Cell-Associated Immunotherapies

Nov 15, 2022

The prognosis is bad for one of the aggressive peripheral T-cell neoplasms, adult T-cell leukemia/lymphoma (ATLL). The development of ATLL pathogenesis was consistently shown to be characterized by es...

California Files Suit Over 'Forever Chemicals' in Water

Nov 14, 2022

MONDAY, Nov. 14, 2022 (HealthDay News) -- The state of California is suing several companies for their role in manufacturing "forever chemicals." The lawsuit filed Thursday also claims that the compan...

California Voters Ban Flavored Tobacco, and a Cigarette Maker Is Suing

Nov 14, 2022

MONDAY, Nov. 14, 2022 (HealthDay News) -- Only one day after California voters approved allowing a state law banning flavored tobacco products to take effect, a tobacco giant has sued to prevent it.R....

Acupuncture Reduces Aromatase Inhibitor-Related Joint Pain

Nov 14, 2022

MONDAY, Nov. 14, 2022 (HealthDay News) -- Among women with early breast cancer who have aromatase inhibitor-related joint pain, pain at 52 weeks is reduced with true acupuncture (TA) compared with sha...

Parkinsonism, Parkinson Disease Risk Up With Bilateral Oophorectomy Before 43

Nov 14, 2022

MONDAY, Nov. 14, 2022 (HealthDay News) -- Premenopausal women who undergo bilateral oophorectomy before age 43 years have an increased risk for parkinsonism and Parkinson disease (PD), according to a ...

HCC Treatment with CLDN1 Specific Antibodies Suppresses Carcinogenic Signaling and Reprograms the Tumor Microenvironment

Nov 14, 2022

One of the top causes of cancer-related mortality globally is hepatocellular carcinoma (HCC). Despite the approval of new treatments, the prognosis and treatment response of patients with advanced HCC...

Safety & Efficacy of the Oral TLR8 Agonist Selgantolimod in Patients with Chronic Hepatitis B Under Viral Suppression

Nov 14, 2022

Hepatitis B virus (HBV) is suppressed in vitro by selgantolimod (GS-9688), a toll-like receptor 8 (TLR8) agonist. In Phase 2 research, researchers assessed the safety and effectiveness of weekly selga...

Survival Benefit of AD-LND in Patients Undergoing Liver Resection for cN0 ICC

Nov 14, 2022

Although clinically node-negative (cN0) patients should have lymphadenectomy, lymph node status is a significant predictor of survival in intrahepatic cholangiocarcinoma (ICC). However, it was up for ...

Safety & Efficacy of 90Y-FAPI-46 RLT in Patients with Advanced Sarcoma & Other Cancer Entities

Nov 14, 2022

In this study, researchers present data on the efficacy and safety of 90Y-labeled FAPI-46 (90Y-FAPI-46-RLT) in patients with advanced sarcoma, pancreatic cancer, and other cancer entities. Patients wi...

Peripheral Cytokines & Lymphocyte Populations Alter by Combined MEK/PD-L1 Inhibition in Advanced BTC

Nov 14, 2022

Biliary Tract Cancers (BTC) are particularly difficult to treat since they are resistant to chemotherapy and immunotherapy. When used in conjunction with PD-L1 blocking, MEK inhibition (MEKi)-based re...

Cancer and Hospice: Earlier Conversations Improve QOL

Nov 11, 2022

For patients with advanced cancer, the last months of life are full seemingly impossible questions: What treatment options are available? Will they buy me more time? What will my QOL look like? What a...

Multiple Myeloma Is Associated with Loss of COP9 Signalosome Genes at 2q37

Nov 11, 2022

The development of a multidrug-resistant condition is a significant factor in myeloma mortality. Widely used immunomodulatory drugs (IMiDs) and more recent CRBN E3 ligase modulator drugs (CELMoDs), wh...

A Novel CD19/CD22/CD3 Trispecific Antibody Enhances Therapeutic Efficacy and Overcomes Immune Escape in B-ALL

Nov 11, 2022

The most effective bispecific antibody (bsAb) to date has been the bispecific T-cell engager (BiTE) blinatumomab against CD19 and CD3. Nevertheless, a sizeable portion of patients did not respond to t...

The Phenotype and Function of CD26+ And CD161+ T Lymphocytes in Splenic Marginal Zone Lymphomas

Nov 11, 2022

Regulatory T-cells (Tregs) play a crucial role in maintaining immunological balance and regulating the body's response to tumors in lymphoma patients. However, research on the role of Tregs in the bio...

Prognostic Factors in Patients with Early-Stage EGFR-Mutant Nsclca

Nov 11, 2022

Surgery is still the primary treatment for patients with early-stage, EGFR mutation-positive (EGFR-M+), non-small cell lung cancer (NSCLC), although tailored adjuvant medicines are increasingly being ...