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Oncology / Hematology

Nab-Paclitaxel, Pembrolizumab Combo Active in Advanced Urothelial Cancer

Nov 10, 2022

THURSDAY, Nov. 10, 2022 (HealthDay News) -- For patients with platinum-refractory or cisplatin-ineligible advanced urothelial cancer, the combination of nab-paclitaxel and pembrolizumab is promising, ...

Health Care Access May Affect Receipt of Therapy in Ovarian Cancer

Nov 10, 2022

THURSDAY, Nov. 10, 2022 (HealthDay News) -- Health care access (HCA) dimensions are associated with receipt of guideline-concordant therapy, but they do not fully explain racial disparities among pati...

Women with Venous Thromboembolism and Abnormal Menstrual Bleeding Related to Anticoagulation

Nov 10, 2022

In women of reproductive age using anticoagulants, preliminary data and clinical experience had revealed an increased risk of abnormal uterine bleeding (AUB), but more conclusive evidence was needed. ...

EGFR Mutated Non–Small Cell Lung Cancer Compared with Gefitinib Alone

Nov 10, 2022

Gefitinib with chemotherapy significantly increased progression-free survival (PFS), and overall survival (OS) compared to gefitinib alone in patients with untreated non-small-cell lung cancer carryin...

TP53-Mutated Myeloid Neoplasms are Associated with Lenalidomide Therapy

Nov 10, 2022

Growing data suggested that under the positive selection pressure of chemo- and radiation treatments, therapy-related myeloid neoplasms (t-MNs) with driver gene mutations develop in the context of clo...

High Endometrial Cancers with Hypermethylated MLH1 Promoter Have Distinct Molecular and Clinical Profiles

Nov 10, 2022

Microsatellite instability-high (MSI-H) endometrial carcinomas are underpinned by distinct mechanisms of DNA mismatch repair deficiency (MMR-D). Researchers aimed to describe the clinical and genetic ...

The Detection of Occult Recurrence of Oropharyngeal Cancer Using HPV-Modified Viruses in Circulating Tumor Tissues

Nov 10, 2022

Oropharyngeal squamous cell carcinoma (OPSCC) caused by human papillomavirus (HPV) had a high cure rate. However, 15–25% of individuals will experience a recurrence despite this. Physical exams and ...

Options Explored for MM That Relapses After BCMA CAR T Therapy

Nov 10, 2022

WEDNESDAY, Nov. 9, 2022 (HealthDay News) -- Patients with multiple myeloma that relapses after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR T) therapy can potentiall...

American Society for Radiation Oncology, Oct. 23-26

Nov 09, 2022

The annual meeting of the American Society for Radiation Oncology was held from Oct. 23 to 26 in San Antonio and attracted approximately 11,000 participants from around the world, including physician...

Overall Cancer Mortality 18 Percent Higher in AI/AN Versus Whites

Nov 09, 2022

TUESDAY, Nov. 8, 2022 (HealthDay News) -- Overall cancer rates are 2 percent higher and cancer mortality is 18 percent higher for American Indian and Alaska Native (AIAN) individuals compared with Whi...

Neoadjuvant Nivolumab Plus Chemotherapy in Operable Stage IIIA Non-Small-Cell Lung Cancer (NADIM phase II trial)

Nov 09, 2022

In the NADIM trial, neoadjuvant chemotherapy combined with nivolumab was successful in treating resectable non-small-cell lung cancer (NSCLC). The investigation of the circulating tumor DNA (ctDNA) an...

RET Fusion-Positive Non-Small Cell Lung Cancer Patients Receiving Selpercatinib

Nov 09, 2022

RET fusion-positive non-small-cell lung cancer (NSCLC) patients can now get therapy with selpercatinib, a first-in-class, powerful, highly selective, and CNS-active RET kinase inhibitor. To further ch...

Transfusion Medicine Diagnostics Derived from Pluripotent Stem Cells

Nov 09, 2022

More than 10 million red blood cell (RBC) transfusions are performed annually in the United States alone, making it one of the most popular medical therapies. However, for transfusion efficacy and saf...

Hemostasis is Impair by GGCX Mutants That Lack Processivity and Full Carboxylation

Nov 09, 2022

Multiple carboxylated Glus (Glas) is produced by γ-Glutamyl carboxylase (GGCX) in vitamin K-dependent (VKD) proteins, which are necessary for their activities. For a study, researchers demonstrated t...

Relapse of MYC-amplified Medulloblastoma is Associated With OLIG2

Nov 09, 2022

The researchers compared radiation sensitivity in OLIG2-high and OLIG2-low tumors in patient-derived xenograft (PDX) lines and assessed OLIG2 expression in a panel of mouse MYC-amplified medulloblast...

Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non–Muscle-Invasive Bladder Cancer

Nov 09, 2022

Cancer screening, prevention, and therapy can be made more specific to each individual with the help of knowledge about inherited germline variations. Patients with locally advanced or metastatic urot...

Safety, Immunogenicity, and 1-Year Efficacy of UCPVax in Patients With Refractory Advanced NSCLC

Nov 07, 2022

The universal cancer peptide-based vaccination (UCPVax) induces a CD4+ T helper-1 response that is directed against telomerase by combining two carefully chosen helper peptides. In the phase Ib/IIa st...

AENEAS: Aumolertinib Vs. Gefitinib as First-Line Therapy for Locally Advanced or Metastatic NSCLC With EGFR Exon 19 Deletion or L858R Mutations

Nov 07, 2022

A brand-new third-generation epidermal growth factor receptor tyrosine kinase inhibitor authorized in China is called aumolertinib (formerly known as almonertinib; HS-10296). Researchers compared the ...

Therapy for Stage IV NSCLC With Driver Alterations

Nov 07, 2022

For a study, researchers updated the 2021 ASCO and Ontario Health (Cancer Care Ontario) guideline on systemic treatment for patients with stage IV non-small-cell lung cancer (NSCLC) with driver change...

HSCT for Adolescents & Adults with Inborn Errors of Immunity

Nov 07, 2022

For newborns and children with multiple inborn errors of immunity (IEI), allogeneic hematopoietic stem cell transplantation (HSCT) is the gold standard curative treatment; nevertheless, adolescents an...