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Skin Cancer

AACR 2020: Treatment Holiday Worsens PFS in BRAF-Mutant Melanoma

May 01, 2020

Although previous studies suggest objective responses with BRAF and MEK inhibitors in the majority of patients with BRAF-mutant melanoma, data also suggest that acquired resistance limits response dur...

Changing Therapeutic Landscape for Melanoma With Multiple Brain Metastases.

Apr 22, 2020

Over 90 000 people are expected to be diagnosed with melanoma in the United States this year. The development of brain metastases is particularly difficult to manage. Over the past few years, melanoma...

Efficient Isolation, Culture, Purification and Stem Cell Expression Profiles of Primary Tumor Cells Derived from Uterine Cervical Squamous Cell Carcinoma.

Apr 22, 2020

Since not too many human uterus cervical squamous cell carcinoma (CSCC) cell lines in existance, efficient isolation, culture and purification protocols for primary CSCC cells were optimized as a tool...

Zr-Labeled Anti-PD-L1 Antibody Fragment for Evaluating PD-L1 Levels in Melanoma Mouse Model.

Apr 22, 2020

The rise of programmed death-1 (PD-1)/PD-L1 immune checkpoint inhibitor therapy has been one of the most promising developments in melanoma research. However, not all the melanoma patients respond to ...

The secretome of skin cancer cells activates the mTOR/MYC pathway in healthy keratinocytes and induces tumorigenic properties.

Apr 14, 2020

Cutaneous squamous cell carcinoma (cSCC) is the most prominent tumor of non-melanoma skin cancers and the most aggressive tumor among keratinocyte carcinoma of the skin, showing a high potential for l...

Histologic features of melanoma associated with germline mutations of CDKN2A, CDK4, and POT1 in melanoma-prone families from the United States, Italy, and Spain.

Apr 14, 2020

CDKN2A, CDK4, and POT1 are well-established melanoma-susceptibility genes.We evaluated melanoma histopathology for individuals with germline mutations of CDKN2A, CDK4, and POT1.We assessed histopathol...

Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.

Apr 14, 2020

Angiostrongylus cantonensis is a metastrongyloid nematode that causes eosinophilic meningoencephalitis in humans. A high infestation of A. cantonensis can cause permanent brain damage or even death. T...

Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy.

Apr 14, 2020

BRAF V600 mutation influences cellular signaling pathways for melanoma development. However, the role of oncogenic BRAF in adaptive stress response pathways is not fully understood. Here, we show that...

DGUOK-AS1 promotes cell proliferation in cervical cancer via acting as a ceRNA of miR-653-5p.

Apr 14, 2020

Cervical cancer (CC) holds the second highest incidence and is the fourth dominating cause of cancer-induced death in women. It has been widely accepted that long noncoding RNAs (lncRNAs) are implicat...

Impact of sarcopenia on survival and late toxicity in head and neck cancer patients treated with radiotherapy.

Apr 07, 2020

Sarcopenia is emerging as an adverse prognostic factor for survival and complication risk in cancer patients. This study aims to determine the impact of sarcopenia on survival and late toxicity in a l...

Chemotherapy after immune checkpoint blockade in patients with recurrent, metastatic squamous cell carcinoma of the head and neck.

Apr 07, 2020

Given that immune checkpoint inhibitors (ICIs) are now preferred agents in first-line treatment of recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN), we retrospectively s...

Thyroid squamous cell carcinoma: a unique type of cancer in World Health Organization classification.

Apr 07, 2020

The aim is to review the features of 117 primary squamous cell carcinomas of thyroid which meet the histological criteria of World Health Organization classification of endocrine tumours. The carcinom...

Melanoma detection using adversarial training and deep transfer learning.

Apr 07, 2020

Skin lesion datasets consist predominantly of normal samples with only a small percentage of abnormal ones, giving rise to the class imbalance problem. Also, skin lesion images are largely similar in ...

Article Addresses Management of Cancer Care During COVID-19

Mar 29, 2020

MONDAY, March 23, 2020 (HealthDay News) -- Management of cancer care during the coronavirus 2019 (COVID-19) pandemic is addressed in a special feature article published online March 20 in the Journal ...

Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome.

Mar 19, 2020

Background Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local tre...

Functional Outcomes Regarding Facial Artery Musculomucosal Flap for Reconstruction of Partial Glossectomy Defects.

Mar 19, 2020

The surgical management and reconstruction after ablation of squamous cell carcinoma of the oral tongue and floor of mouth are quite challenging. If not reconstructed properly, the deficits resulting ...

Relapse of Nephrotic Syndrome after Adrenocorticotrophic Hormone-Induced Remission: Implications of Adrenocorticotrophic Hormone Antibodies.

Mar 19, 2020

Prolonged use of corticosteroids continues to be the mainstay in the management of most proteinuric glomerulopathies, but is limited by extensive side effects. Alternative medications such as adrenoco...

LINE-1 hypomethylation in canine malignant mucosal melanoma.

Mar 19, 2020

Canine malignant melanoma is a common cancer with a high mortality rate and is a clinically important disease. DNA methylation has been considered to be a potential tumorigenic mechanism through aberr...

Large Decrease Seen in Melanoma Mortality From 2013 to 2016

Mar 19, 2020

THURSDAY, March 19, 2020 (HealthDay News) -- From 2013 to 2016, there was a large decrease of 17.9 percent in melanoma mortality, according to a study published online March 19 in the American Journal...

Anti-melanogenic activity of ocotillol-type ginsenosides from Panax vietnamesis Ginseng.

Mar 13, 2020

The ocotillol (OCT)-type saponins have been known as a tetracyclic triterpinoid, possessing five or six-membered epoxy ring in the side chain. Interestingly, this type saponin was mostly in Panax viet...