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Ophthalmology General

RNA-Sequencing Analysis Reveals the Role of Mitochondrial Energy Metabolism Alterations and Immune Cell Activation in Form-Deprivation and Lens-Induced Myopia in Mice.

Dec 25, 2023

Myopia is a substantial global public health concern primarily linked to the elongation of the axial length of the eyeball. While numerous animal models have been employed to investigate myopia, the s...

A Corneal Biomechanical Study Measured with a Scheimpflug Dynamic Analyser in Soft Contact Lens Wearers.

Dec 25, 2023

The aim of this study was to evaluate the biomechanical changes in the cornea after wearing soft contact lenses (CLs) in healthy myopic patients measured with a Corvis ST (CST, Oculus Optikgeräte Gmb...

Dry eye syndrome symptoms in patients with psoriasis.

Dec 25, 2023

Psoriasis is one of the most common dermatoses associated with a variety of comorbidities. There have been some reports on its possible association with ocular disorders however dry eye syndrome (DES)...

Ocular surface changes in mice with streptozotocin-induced diabetes and diabetic polyneuropathy.

Dec 25, 2023

Diabetes mellitus (DM) is a leading risk factor for corneal neuropathy and dry eye disease (DED). Another common consequence of DM is diabetic peripheral polyneuropathy (DPN). Both complications affec...

Glycation-Resistant mPON2 Shows Superior Efficacy Against Diabetic Retinopathy

Dec 25, 2023

Paraoxonase 2 (PON2) is an intracellular anti-oxidant protein ubiquitously expressed in all cells and reduces reactive oxygen species, endoplasmic reticulum (ER) stress, further improves mitochondrial...

12-HETE activates Müller glial cells: the potential role of GPR31 and miR-29.

Dec 25, 2023

Diabetic retinopathy (DR) is a neurovascular complication of diabetes, driven by an intricate network of cellular and molecular mechanisms. This study sought to explore the mechanisms by investigating...

Feedforward connectivity patterns from visual areas to the front of the brain contain information about sensory stimuli regardless of awareness or report.

Dec 25, 2023

Current theories of consciousness can be categorized to some extent by their predictions about the putative role of the prefrontal cortex (PFC) in conscious perception. One family of the theories prop...

Developing ophthalmology in Cambodia.

Dec 25, 2023

Over 180,000 Cambodian people are blind and a further 10,000 suffer avoidable blindness each year. Ninety percent of this blindness is avoidable, 79% is curable and 11% is preventable. Three-quarters ...

Boston Keratoprosthesis type 1 (KPro) without contact lens wearing in end-stage corneal disease: The APEC experience.

Dec 18, 2023

To report the visual outcomes and survival analysis of keratoprosthesis without contact lens wearing in a tertiary eye care hospital in Mexico City, Asociación Para Evitar La Ceguera (APEC, Coyoacán...

Predicting cell-type specific disease genes of diabetes with the biological network.

Dec 18, 2023

Type 2 diabetes (T2D) is a chronic condition that can lead to significant harm, such as heart disease, kidney disease, nerve damage, and blindness. Although T2D-related genes have been identified thro...

Targeting scleral remodeling and myopia development in form deprivation myopia through inhibition of EFEMP1 expression.

Dec 18, 2023

The role of extracellular matrix (ECM) remodeling in the axial elongation associated with myopia has not been fully elucidated, although it is considered a significant factor. EFEMP1, a regulator of E...

Bayesian posterior density estimation reveals degeneracy in three-dimensional multiple emitter localization.

Dec 18, 2023

Single-molecule localization microscopy requires sparse activation of emitters to circumvent the diffraction limit. In densely labeled or thick samples, overlap of emitter images is inevitable. Single...

FL-41 Tint Reduces Activation of Neural Pathways of Photophobia in Patients with Chronic Ocular Pain.

Dec 18, 2023

To assess the therapeutic effect of tinted lenses (FL-41) on photophobia and light-evoked brain activity using functional magnetic resonance imaging (fMRI) in individuals with chronic ocular surface p...

A PEDF peptide mimetic effectively relieves dry eye in a diabetic murine model by restoring corneal nerve, barrier, and lacrimal gland function.

Dec 18, 2023

The study investigated effectiveness of a novel PEDF peptide mimetic to alleviate dry eye-like pathologies in a Type I diabetic mouse model established using streptozotocin.Mice were treated topically...

Effects of CSF1R/p-ERK1/2 signaling pathway on RF/6A cells under high glucose conditions.

Dec 18, 2023

This study analyzed how high glucose affects CSF1R and p-ERK1/2 expression in RF/6A cells.The cells were cultured as high glucose (HG) and normal control (C) groups, and CSF1R shRNA was introduced. Re...

Evaluation of Microvascular Complications in Kidney Recipients with Post-Transplant Diabetes Mellitus.

Dec 18, 2023

Limited data on microvascular complications in patients with post-transplant diabetes (PTDM) is an obstacle to developing follow-up algorithms.To evaluate diabetic microvascular complications in patie...

Application of Patient Sentiment Analysis to Evaluate Glaucoma Care.

Dec 18, 2023

Patients utilize online physician reviews to decide between and rate ophthalmologists. Sentiment analysis allows for better understanding of patient experiences. In this study, Valence Aware Dictionar...

Primary Practice Emphasis Area and Diversity among Board-Certified Ophthalmologists.

Dec 18, 2023

To describe the ophthalmology primary practice emphasis area by underrepresented in medicine (URiM) status using the American Board of Ophthalmology (ABO) Diplomates database.Retrospective cohort stud...

Consensus Guidelines for Ocular Surveillance of von Hippel-Lindau Disease.

Dec 18, 2023

To develop guidelines for ocular surveillance and early intervention for individuals with von Hippel-Lindau (VHL) disease.Systematic review of the literature.Expert panel of retina specialists and ocu...

An evaluation of optometric advanced skills within a UK tertiary based setting.

Dec 18, 2023

Hospital-based optometrists are undertaking extended roles across ophthalmology that may require them to perform advanced skills (AS). Moorfields Eye Hospital (MEH) is the largest UK employer of hospi...

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