Efficient therapies are available for the treatment of osteoporosis. Anti-resorptive therapies, including bisphosphonates and denosumab increase bone mineral density (BMD) and reduce the risk of fractures by 20-70%. Bone-forming...Read More
Sports Medicine Orthopedics
Lumbar intervertebral disc characterization through quantitative MRI analysis: An automatic voxel-based relaxometry approach.
To develop an automated pipeline based on convolutional neural networks to segment lumbar intervertebral discs and characterize their biochemical composition using voxel-based relaxometry, and establish local associations with...Read More
Emerging evidence highlights the role of the long noncoding RNA (lncRNA) KCNQ1OT1 in fracture healing. Osteoblast proliferation, migration, and survival are pivotal during this process. In this study, we aimed to improve our...Read More
Pulsed Radiofrequency Treatment for Bertolotti’s Syndrome Presenting with Low Back Pain: Report of Four Cases.
Pulsed radiofrequency (PRF) has been used successfully to treat myriad types of chronic pain, including spinal radicular pain and that associated with facet arthropathy. Although there are a few reports about radiofrequency...Read More
Modulation of pain perception by oxytocin (OXT) has attracted increased scientific and clinical interest. Neural mechanisms underlying these effects are poorly understood. In this study, we aimed to investigate the effects of...Read More
Is Bone Non-Union, Vertebral Deformity, or Spino-Pelvic Malalignment the Best Therapeutic Target for Amelioration of Low Back Pain after Osteoporotic Vertebral Fracture?
Cohort study (level 3).To identify independent risk factors for residual low back pain (LBP) following osteoporotic vertebral fracture (OVF).Non-union has been proposed as the primary cause of residual LBP following OVF....Read More
Traumatic Atlanto-occipital Dislocation: Analysis of 15 Survival Cases With Emphasis on Associated Upper Cervical Spine Injuries.
Retrospective case analyses.The aim of this study was to investigate the incidence and characteristics of associated upper cervical spine injuries in 15 survival cases of traumatic atlanto-occipital dislocation (AOD).Traumatic...Read More
Research studies to understand the biomechanics of manual wheelchair propulsion often incorporate experimental data and mathematical models. This project aimed to advance this field of study by developing a two-dimensional model...Read More
Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial.
Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could reduce mortality and major...Read More