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Arthritis

RA and depression.

May 03, 2021

Depression constitutes the most frequent comorbid condition associated with rheumatoid arthritis (RA), with prevalence rates ranging from 14% to 48%. This wide range can be explain by several factors ...

Update on pain in arthritis.

Apr 29, 2021

Osteoarthritis is a degenerative joint disease that features pain as a hallmark symptom. This review summarises progress and obstacles in our understanding of pain mechanisms in arthritis.Pain phenoty...

Tofacitinib in the Treatment of Moderate-to-Severe Rheumatoid Arthritis in China: A Cost-Effectiveness Analysis Based on a Mapping Algorithm Derived from a Chinese Population.

Apr 12, 2021

To estimate the cost-effectiveness of tofacitinib for patients with moderate-to-severe rheumatoid arthritis (RA) who failed conventional synthetic disease-modifying antirheumatic drugs from the Chines...

Awareness of and reactions to the health harms of sugary drinks: An online study of U.S. parents.

Apr 08, 2021

Evidence about the health problems associated with sugary drink consumption is well-established. However, little is known about which sugary drink health harms are most effective at changing consumers...

Effects of Tai Chi and running on blood oxygen saturation: a pilot study.

Apr 05, 2021

Large drops in blood oxygen saturation (SpO2) to levels as low as 84% was observed following Tai Chi practice, during a study on the effects of Tai Chi on SpO2. The objectives of the current pilot stu...

Outcome of a metaphyseal reverse total shoulder replacement in rheumatoid arthritis.

Apr 01, 2021

To assess the clinical and radiological results of a metaphyseal reverse total shoulder arthroplasty (rTSA) without diaphyseal stem, in rheumatoid arthritis (RA) patients.Forty-five shoulders in 36 co...

PAD4 takes charge during neutrophil activation: impact of PAD4 mediated NET formation on immune-mediated disease.

Mar 29, 2021

Peptidyl arginine deiminase 4 (PAD4) is an enzyme expressed in neutrophils that, when activated, can drive the formation of neutrophil extracellular traps (NETs). Uncontrolled activation of PAD4 and s...

Paradoxical Psoriasis in Children Receiving Anti-TNFα Treatment for Inflammatory/autoimmune Disease.

Mar 25, 2021

Tumor necrosis factor alpha inhibitors (TNFi) are widely used in children with autoimmune and autoinflammatory conditions. Although TNFi are approved to treat psoriasis, they have also been shown to p...

Patient Perceptions of Psoriatic Arthritis Management and Communication with Physicians in Australia: Results from a Patient Survey.

Mar 25, 2021

The objective of this report was to evaluate perceptions of psoriatic arthritis (PsA) treatment and satisfaction with healthcare professional (HCP) communication among patients with PsA in Australia, ...

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.

Mar 25, 2021

Arthritis typically involves recurrence and progressive worsening at specific predilection sites, but the checkpoints between remission and persistence remain unknown. Here, we defined the molecular a...

Impact of rheumatoid arthritis and biologic and targeted synthetic disease modifying antirheumatic agents on cancer risk and recurrence.

Mar 22, 2021

Several new therapeutic drugs are now available for the management of rheumatoid arthritis (RA). Given that RA has been associated with an increased risk of certain cancers like lymphoma and lung canc...

Managing noncommunicable diseases during the COVID-19 pandemic in Brazil: findings from the PAMPA cohort.

Mar 18, 2021

The objective was to identify the impact of social distance in the management of noncommunicable diseases (NCD) in the adult population from the state of Rio Grande do Sul, southern Brazil. This is an...

Predictors of functional capacity as measured by the Glittre activities of daily living test in women with rheumatoid arthritis.

Mar 18, 2021

Although pulmonary involvement is the most common extra-articular manifestation of rheumatoid arthritis (RA), traditional pulmonary function tests (PFTs) do not show a good correlation with the field ...

Patient perspectives on how to improve education on medication side effects: cross-sectional observational study at a rheumatology clinic in The Netherlands.

Mar 18, 2021

Rheumatoid arthritis (RA) patients often report lacking information on medication side effects. The aims of this study were to observe how rheumatology healthcare providers deliver medication informat...

Sex Differences Among Patients With Gout

Mar 17, 2021

“Gout is the most common type of inflammatory arthritis, yet it is a predominantly male disease,” explains Ritch te Kampe, PhD, MSc. “Despite an increasing prevalence of gout in the aging female...

Inhibition of NF-κB signaling and HSP70/HSP90 proteins by newly synthesized hydrazide derivatives in arthritis model.

Mar 15, 2021

In the current study, the N-benzylidene-4-((2-hydroxynaphthalene-1-yl) diazenyl) hydrazides (NCHDH and NTHDH) were evaluated against the Carrageenan- and CFA-induced models. During the preliminary in...

Remote Measurement in Rheumatoid Arthritis: Qualitative Analysis of Patient Perspectives.

Mar 11, 2021

Rheumatoid arthritis (RA) is characterized by recurrent fluctuations in symptoms such as joint pain, swelling, and stiffness. Remote measurement technologies (RMTs) offer the opportunity to track symp...

Placebo and nocebo responses in randomized controlled trials of Janus kinase inhibitor monotherapy for rheumatoid arthritis : A meta-analysis.

Mar 11, 2021

The goal of this meta-analysis was to assess the frequency and magnitude of placebo and nocebo responses in placebo-controlled randomized controlled trials (RCTs) of Janus kinase (JAK) inhibitor monot...

Lipid metabolism in cartilage and its diseases: a concise review of the research progress.

Mar 01, 2021

The homeostasis of the vertebrate body depends on anabolic and catabolic activities that are closely linked the inside and outside of the cell. Lipid metabolism plays an essential role in these metabo...

Validation of Self-Reported Rheumatoid Arthritis Using Medicare Claims: A Nationally Representative Longitudinal Study of Older Adults.

Feb 25, 2021

To determine the validity of self-reported physician diagnosis of rheumatoid arthritis (RA) using multiple gold-standard measures based on Medicare claims in a nationally representative sample of olde...