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Pain General

Editorial Commentary: Artificial Intelligence Analysis of Biomedical, Large, Clinical Registry Data Using Machine Learning Requires Tens of Thousands of Subjects and a Focus on Substantial Clinical Benefit: MCID Is too Low a Bar.

Jan 15, 2024

As the field of arthroscopic hip preservation surgery grows, large high-quality registries represent a foundational study design for establishing whether hip arthroscopy is effective for patients with...

Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice.

Jan 15, 2024

Chronic pain presents an enormous personal and economic burden and there is an urgent need for effective treatments. In a mouse model of chronic neuropathic pain, selective silencing of key neurons in...

Update of statistical analysis plan for: Integration of smoking cessation into standard treatment for patients receiving opioid agonist therapy who are smoking tobacco: protocol for a randomised controlled trial (ATLAS4LAR).

Jan 08, 2024

This protocol paper presents an updated statistical analysis plan of the protocol of a randomised controlled trial. The randomised controlled trial investigates the effect of integrating smoking cessa...

Activation of ATP-sensitive potassium channels triggers migraine attacks independent of calcitonin gene-related peptide receptors: a randomized placebo-controlled trial.

Jan 08, 2024

The present study aimed to investigate whether levcromakalim, a K channel opener, induces migraine attacks in people with migraine pre-treated with erenumab, a monoclonal CGRP receptor antibody.In thi...

Switching anti-CGRP monoclonal antibodies in chronic migraine: real-world observations of erenumab, fremanezumab and galcanezumab.

Jan 08, 2024

The anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP-mAb) are effective in migraine; however, few studies have examined the benefit of switching from one anti-CGRP-mAb to another....

The patient journey of fibromyalgia in Latin America.

Jan 08, 2024

To explore the patient journey of people with fibromyalgia (FM) in Latin American countries in order to identify problems in health care and other areas that may be resolvable.Qualitative study with p...

Imaging study of coccygeal morphology in adolescent idiopathic scoliosis.

Jan 08, 2024

The correlation between scoliosis and sagittal curvature of the cervical, thoracic, and lumbar spine have already been reported in previous studies. However, as a part of the spine, the change in cocc...

Impact of Rheumatoid Arthritis and Seropositivity on the Risk of Non-Cystic Fibrosis Bronchiectasis.

Jan 08, 2024

Despite the coexistence of bronchiectasis and rheumatoid arthritis (RA) and the poor prognosis associated with the combination of conditions, no longitudinal studies that comprehensively evaluated whe...

Cortisol as a Marker of Pain and Distress Following Acute Musculoskeletal Trauma.

Jan 08, 2024

The best available predictors of chronic pain development broadly encompass baseline metrics of cognition (i.e. beliefs/expectations) about the trauma and resulting symptoms. In the context of musculo...

ELECTROPHYSIOLOGICAL ANALYSES OF HUMAN DORSAL ROOT GANGLIA AND HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED SENSORY NEURONS FROM MALE AND FEMALE DONORS.

Jan 01, 2024

Human induced pluripotent stem cell-derived sensory neurons (hiPSC-SNs) and human dorsal root ganglia neurons (hDRG-N) are popular tools in the field of pain research; however, few groups make use of ...

Athletes and Experimental Pain: A systematic review and meta-analysis.

Jan 01, 2024

The evidence that athletes respond to and report indices of experimental pain differently to non-athlete populations was analysed. Databases screened were SPORTDiscus, PubMED, PsycArticles, the Cochra...

Knockdown of Galectin-9 alleviates rheumatoid arthritis through suppressing TNF-α-induced activation of fibroblast-like synoviocytes.

Dec 25, 2023

The role of Galectin-9 (Gal-9) in the pathogenesis of rheumatoid arthritis (RA) remains unclear. This study aimed to investigate the mechanism of action and therapeutic potential of Gal-9 in RA. We de...

Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood. The HUNT Study.

Dec 25, 2023

Opioid and nonopioid analgesics are commonly prescribed to young people to alleviate pain. Even short-term prescriptions increase the risk of persistent use and future misuse of potent analgesics, suc...

Effect of exposure-based vs traditional cognitive behavior therapy for fibromyalgia: a two-site single-blind randomized controlled trial.

Dec 25, 2023

Fibromyalgia is a debilitating pain condition for which treatment effects are typically modest. The most evaluated psychological treatment is traditional cognitive behavior therapy (T-CBT), but promis...

Feature-based multimodal registration framework for vertebral pose estimation.

Dec 18, 2023

The reliable estimation of the vertebral body posture helps to aid a safe and effective spine surgery. The proposed work aims to present an MR to X-ray image registration to assess the 3D pose of the ...

Waiting in Pain II: An updated analysis of the multidisciplinary staffing levels and clinical activity in Australian specialist persistent pain services.

Dec 18, 2023

This study provides an update on multidisciplinary staffing and clinical activity in Australian specialist persistent pain services. Of the 109 services identified, 57 responded, met inclusion criteri...

Racial Differences in Movement-Related Appraisals and Pain Behaviors among Adults with Chronic Low Back Pain.

Dec 11, 2023

Research documents racial disparities in chronic low back pain (CLBP). Few studies have examined racial disparities in movement-related appraisals and no studies have examined anticipatory appraisals ...

Chronic pain among middle-aged and older adults in the United States: The role of everyday discrimination and racial/ethnic identity.

Dec 11, 2023

Chronic pain disproportionately affects middle-aged and older adults in the United States. Everyday discrimination is associated with worse pain outcomes and is more prevalent among adults from racial...

The effect of a six-week Aqua Pilates and Aqua Stretch intervention on pain, function, and quality of life in patients affected by ankylosing spondylitis: A rater-blind randomized controlled trial.

Nov 20, 2023

There has been a dearth of research into the benefits of water-based workouts for ankylosing spondylitis (AS) patients.This study aimed to compare the effect of Aqua Stretch and Aqua Pilates in improv...

Fluoroscopy-based robotic assistance for total hip arthroplasty improves acetabular cup placement accuracy for obese patients compared to the manual, fluoroscopic- assisted technique.

Nov 20, 2023

Patient obesity is a risk factor for poor acetabular cup positioning in total hip arthroplasty (THA).To assess the impact of using a novel, fluoroscopy-based robotic THA system on acetabular cup place...

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