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Opioids

Chronic High-Risk Prescription Opioid Use in Patients With HIV

Jul 20, 2021

A study has found that opioid prescriptions, including receipt of prescriptions for long durations, appear to be common among people living with HIV who are in primary care. Efforts are needed to prev...

Longitudinal effects of adverse childhood experiences on substance use transition patterns during young adulthood.

Jul 12, 2021

Few studies have investigated how adverse childhood experiences are associated with substance use patterns during young adulthood, a crucial developmental period.The objective of this study was to ext...

CME/CE: Assessing Prescription Opioid Medical Use & Misuse in Parents & Offspring

Jul 02, 2021

This course discusses a study that examined associations between parental and adolescent prescription opioid medical use and misuse....

Examining Characteristics Linked With Poor Outcomes in Opioid Prescribing

Jun 30, 2021

“In recent decades, the medical community has become acutely aware of the dangers posed by prescription opioids and their contribution to the opioid epidemic,” explains David R. Foster, PharmD, FC...

Effects of combined THC and heroin vapor inhalation in rats.

Jun 24, 2021

Opioids are effective medications, but they have several key limitations including the development of tolerance, establishment of dependence, diversion for non-medical use, and the development of addi...

Exploring how hospitalization can alter hepatitis c virus treatment prioritization and trajectories in people who use drugs: A qualitative analysis.

Jun 24, 2021

People who use drugs (PWUD) have high rates of hepatitis C virus (HCV) infection. Hospitalization can be a time for PWUD to engage in addiction treatment, but little is known about how hospitalization...

Fatal opioid overdoses in the U.S. declined more than reported between 2017 and 2018.

Jun 10, 2021

: In U.S. death records, many drug overdoses do not have classified drug involvement, which challenges surveillance of opioid overdoses across time and space.: To estimate the 2017-2018 change in opio...

Differences and similarities between emergency department syndromic surveillance and hospital discharge data for nonfatal drug overdose.

Jun 10, 2021

Emergency department (ED) syndromic surveillance and hospital discharge data have been used to detect and monitor nonfatal drug overdose, yet few studies have assessed the differences and similarities...

Prescription opioid policies and associations with opioid overdose and related adverse effects.

Jun 10, 2021

United States (US) policies to mitigate the opioid epidemic focus on reducing access to prescription opioids to prevent overdoses. We examined the impact of state policies in Vermont (July 2017) and M...

Current application of the enhanced recovery after surgery protocol for patients undergoing radical cystectomy: lessons learned from European excellence centers.

Jun 03, 2021

There is no consensus on which items of Enhanced Recovery After Surgery (ERAS) should and should not be implemented in radical cystectomy (RC). The aim of this study is to report current practices acr...

Opioid-Sparing Multimodal Analgesia Protocol for Lumpectomy Patients Results in Superior Postoperative Pain Control.

Jun 03, 2021

We sought to determine if lumpectomy patients who received perioperative opioid-sparing multimodal analgesia reported less pain when compared with those who received traditional opioid-based care.A pr...

Pharmacist medication review: An integrated team approach to serve home-based primary care patients.

May 27, 2021

Comprehensive medication review is a patient-centered approach to optimize medication use and improve patient outcomes. This study outlines a pilot model of care in which a remote corporate-based clin...

Defining and Describing Treatment Heterogeneity in New-Onset Idiopathic Lower Back and Extremity Pain Through Reconstruction of Longitudinal Care Sequences.

May 27, 2021

Despite established guidelines, long-term management of surgically-treated low back pain (LBP) and lower extremity pain (LEP) remains heterogeneous. Understanding care heterogeneity could inform futur...

Improvements on a chemically contiguous hapten for a vaccine to address fentanyl-contaminated heroin.

May 27, 2021

Unintentional overdose deaths related to opioids and psychostimulants have increased in prevalence due to the adulteration of these drugs with fentanyl. Synergistic effects between illicit compounds a...

Deficit of β-endorphin neurons in the hypothalamus and high expression of MOR in mesolimbic structures are related to high alcohol consumption in outbred rats.

May 24, 2021

Clinical studies have postulated that β-endorphin deficiency generates excessive alcohol consumption and, it has been shown that the reduction of β-endorphin neurons increases alcohol intake in anim...

Public support for harm reduction: A population survey of Canadian adults.

May 20, 2021

We described public views toward harm reduction among Canadian adults and tested a social exposure model predicting support for these contentious services, drawing on theories in the morality policy, ...

Distress tolerance and subsequent substance use throughout high school.

May 20, 2021

To examine the association of perceived distress tolerance-one's ability to endure aversive experiences-with subsequent substance use frequency during adolescence.High school students (N = 3,203) we...

A framework for opioid stigma in cancer pain.

May 20, 2021

Millions of patients with cancer pain are treated with prescription opioids each year. However, efforts to mitigate the ongoing opioid crisis result in unintended consequences with opioid pain managem...

Evaluation of analgesic interaction between morphine, maropitant and dexmedetomidine in dogs undergoing ovariohysterectomy.

May 06, 2021

To compare the analgesic effect of morphine combined with maropitant and/or dexmedetomidine to morphine alone given at a higher dose, and to evaluate the pharmacokinetics of the drug combinations, in ...

Predictive Performance of Oximetry to Detect Sleep Apnea in Patients Taking Opioids.

May 06, 2021

Long-term use of opioids for treatment of chronic pain is associated with significant risks including worsening unrecognized or untreated sleep apnea that may increase morbidity and mortality. Overnig...