Advertisement

Opioids

Fentanyl-related substance scheduling as an effective drug control strategy.

May 06, 2021

Fentanyl is now the primary driver of the current opioid crisis. Fentanyl and its analogues are subject to the Controlled Substances Act of 1970, the Controlled Substances Analogue Enforcement Act of ...

Developing a Flexible National Wastewater Surveillance System for COVID-19 and Beyond.

Apr 22, 2021

Wastewater testing offers a cost-effective strategy for measuring population disease prevalence and health behaviors. For COVID-19, wastewater surveillance addresses testing gaps and provides an early...

Enhanced Recovery after Surgery: Benefits for the Fetal Surgery Patient.

Apr 15, 2021

The fetoscopic approach to the prenatal closure of a neural tube defect (NTD) may offer similar advantages to the newborn compared to prenatal open closure of a NTD, with a reduction in maternal risks...

Longitudinal Opioid Surveillance Project Involving Toxicologic Analysis of Postmortem Specimens from 9 Counties in Michigan Suggests the Discovery of New High-Intensity Drug Trafficking Areas.

Apr 15, 2021

Acetyl fentanyl (AF) is a Schedule I fentanyl analog that has been increasingly seen in heroin and fentanyl polydrug toxicity overdoses in Michigan (MI). Drug users are often unaware of the presence o...

Efficacy of Adductor Canal Blocks in Total Knee Arthroplasty.

Apr 15, 2021

Total knee arthroplasty (TKA) is associated with significant postoperative pain. The population receiving TKA is generally elderly and often have multiple comorbidities that can present a challenge to...

PerspectivesRe-legalizing cannabis for medical use in the USA.

Apr 08, 2021

The purpose of this paper is to discuss the history of cannabis, its benefits, risks and the federal re-legalization of cannabis for medical use in the USA.Thirty-six states have legalized cannabis as...

The Effects of Multimodal Analgesia in Critically Ill Patients With Burns

Mar 29, 2021

Pain from burn injuries can be challenging to treat and remains one of the most severe forms of trauma a patient can endure, explains Sierra R. Young, PharmD, BCCCP.  “Patients with burn injuries e...

CDC's Efforts to Quantify Prescription Opioid Overdose Deaths Fall Short.

Mar 25, 2021

In a 2018 report titled, Quantifying the Epidemic of Prescription Opioid Overdose Deaths, four senior analysts of the Centers for Disease Control and Prevention (CDC), including the head of the Epidem...

Maternal continuous oral oxycodone self-administration alters pup affective/social communication but not spatial learning or sensory-motor function.

Mar 25, 2021

The broad use/misuse of prescription opioids during pregnancy has resulted in a surge of infants with Neonatal Opioid Withdrawal Syndrome (NOWS). Short-term irritability and neurological complications...

Opioid Overprescribing and Procedure-Specific Opioid Consumption Patterns for Plastic and Reconstructive Surgery Patients.

Mar 25, 2021

Opioid prescribing practices contribute to opioid misuse, dependency, and diversion. There are currently no comprehensive and quantitative evidence-based guidelines that give procedure-specific recomm...

Assessing Prescription Opioid Medical Use & Misuse in Parents & Offspring

Mar 22, 2021

According to recent data, nearly 50% of adolescents who misuse prescription opioids report obtaining the drugs from relatives or friends. Understanding the parental origins of adolescent prescription ...

Perioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients.

Mar 18, 2021

Despite application of multimodal pain management strategies, patients undergoing spinal fusion surgery frequently report severe postoperative pain. Methadone and ketamine, which are N-methyl-d-aspart...

Enhanced Recovery After Surgery Protocol with Ultrasound-Guided Regional Blocks in Outpatient Plastic Surgery Patients Leads to Decreased Opioid Prescriptions and Consumption.

Mar 18, 2021

Opioids are a mainstay of pain management. To limit the use of opioids, enhanced recovery after surgery (ERAS) protocols implement multimodal approaches to treat postoperative pain.This paper aims to ...

Personalizing Cancer Pain Therapy: Insights from the Rational Use of Analgesics (RUA) Group.

Mar 18, 2021

A previous Delphi survey from the Rational Use of Analgesics (RUA) project involving Italian palliative care specialists revealed some discrepancies between current guidelines and clinical practice wi...

Assessing Perioperative Multimodal Analgesia in Patients With Burns

Mar 03, 2021

Postoperative pain has been shown in prior research to be a major challenge for patients with burns who undergo autologous skin grafting. Burn injuries cause severe pain, with many patients requiring ...

Factor structure and psychometric properties of the Connor-Davidson resilience scale (CD-RISC) in individuals with opioid use disorder.

Feb 25, 2021

Resilience is defined as the capacity for an individual to maintain normal functioning and resist the development of psychiatric disorders in response to stress and trauma. Although previous investiga...

Comparison of psychological symptoms and cognitive functions in patients under maintenance treatment with methadone or buprenorphine, current opioid users and healthy subjects.

Feb 25, 2021

Methadone and buprenorphine can affect the psychological symptoms and cognitive functioning of substance users. This study aimed to compare psychological symptoms and neuropsychological functioning in...

Opioid Mortality Following Implementation of Medical Cannabis Programs in the United States.

Feb 25, 2021

The United States is in the midst of an opioid overdose epidemic. Emerging evidence suggests that medical cannabis (MC) may reduce use of opioids for pain in some individuals, with potential impacts o...

CME: A Closer Look at Patterns in Prescription Opioid Use & Misuse Among Cancer Survivors

Feb 22, 2021

This course discusses a study that analyzed the prevalence of and risk factors for prescription opioid use and misuse in adult cancer survivors and compared patterns with those in people without can...

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.

Feb 22, 2021

Despite major advances, there remains a need for novel anesthetic drugs or drug combinations with improved efficacy and safety profiles. Here, we show that inhibition of cAMP-phosphodiesterase 4 (PDE4...