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Opioids

Effect of suvorexant on morphine tolerance and dependence in mice: Role of NMDA, AMPA, ERK and CREB proteins.

Feb 22, 2021

The major problems of morphine use in the clinic are its tolerance and dependence. This study aimed to investigate the effect of suvorexant, a dual orexin receptor antagonist, on morphine-induced depe...

Evaluation of an emergency department-based opioid overdose survivor intervention: Difference-in-difference analysis of electronic health record data to assess key outcomes.

Feb 22, 2021

In recent years, a number of emergency department (ED)-based interventions have been developed to provide supports and/or treatment linkage for people who use opioids. However, there is limited resear...

Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care.

Feb 18, 2021

Acute low back pain (LBP) is highly prevalent, with a presumed favorable prognosis; however, once chronic, LBP becomes a disabling and expensive condition. Acute to chronic LBP transition rates vary w...

Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: the possible role of μ-opioid receptors and ΔFosB in the brain reward pathway.

Feb 18, 2021

Prenatal opioids exposure negatively affects the neurobehavioral abilities of children born from dependence dams. Adolescent housing conditions can buffer the detrimental impacts of early life experie...

Intermittent REM sleep deprivation attenuates the development of morphine tolerance and dependence in male rats.

Feb 18, 2021

Opioid agonists are used in clinic for pain management, however this application is challenged by development of tolerance and dependence following prolonged exposure. Various approaches have been sug...

Hippocampal TNF-α Signaling Mediates Heroin Withdrawal-Enhanced Fear Learning and Withdrawal-Induced Weight Loss.

Feb 15, 2021

There is significant comorbidity of opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) in clinical populations. However, the neurobiological mechanisms underlying the relationship bet...

PAIN CATASTROPHIZING, OPIOID MISUSE, OPIOID USE, AND OPIOID DOSE IN PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN: A SYSTEMATIC REVIEW.

Feb 15, 2021

The objective of this study was to analyze the cross-sectional and longitudinal association between pain catastrophizing and opioid misuse, opioid use, and opioid dose in people with chronic musculosk...

Carfentanil - from an animal anesthetic to a deadly illicit drug.

Feb 15, 2021

The use of novel synthetic opioids as recreational drugs has become a public health concern as they are implicated in numerous fatal intoxications across the world. Synthetic opioids have played a maj...

Discharge Opioid Prescription Patterns after Kidney Cancer Surgery.

Feb 11, 2021

To describe opioid prescribing patterns for patients undergoing kidney cancer surgery and evaluate associations with medical resource utilization in the postoperative setting.Linked Surveillance, Epid...

Is Opioid-Free Post-Vasectomy Analgesia a Pain? A Single Surgeon Experience.

Feb 11, 2021

To determine the impact of transitioning from opioid to non-opioid analgesia post-vasectomy on unplanned opioid prescriptions and health encounters.A retrospective review for patients who underwent va...

The Effect of Preoperative Opioid Education on Opioid Consumption After Outpatient Orthopedic Surgery: A Prospective Randomized Trial.

Feb 11, 2021

Pain management and opioid consumption following outpatient orthopedic surgery may be influenced by several variables, including knowledge of safe opioid use. A prospective randomized study was undert...

Evaluation of Opioid Prescription and Consumption Habits Following Endovascular Aortic Aneurysm Repair.

Feb 08, 2021

There has been a dramatic rise in opioid-related deaths over the past decade. Most of the reduction strategies have focused on outpatient use; however, recent studies have demonstrated an association ...

Intraoperative Local Injection of Uterosacral Ligaments with Ropivacaine during Uterine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Feb 08, 2021

To perform a systematic review and meta-analysis of all randomized controlled trials that examined the efficacy of intraoperative local injection of the uterosacral ligaments with ropivacaine on posto...

Patterns of dispensed opioids after tonsillectomy in children and adolescents in South Carolina, United States, 2010-2017.

Feb 08, 2021

Tonsillectomy (with or without adenoidectomy) is a common pediatric surgical procedure requiring post-operative analgesia. Because of the respiratory depression effects of opioids, clinicians strive t...

A Closer Look at Patterns in Prescription Opioid Use & Misuse Among Cancer Survivors

Feb 05, 2021

Cancer survivors report higher rates of prescription opioid use than those without the disease, but this may not translate to increased opioid misuse. Caution against opioid misuse is warranted but sh...

Automated quantification of opioid withdrawal in neonatal rat pups using Ethovision® XT software.

Feb 04, 2021

Chronic prenatal exposure to opioids often causes fetal opioid dependence that leads to neonatal opioid withdrawal syndrome (NOWS) shortly after delivery. Rat models of NOWS often require quantifying ...

Tranexamic Acid Has No Effect on Post-operative Hemarthrosis or Pain Control Following ACL Reconstruction Using Bone Patella Tendon Bone Autograft: A Double-Blinded Randomized Control Trial.

Feb 04, 2021

The purpose of this double-blinded randomized controlled trial was to evaluate the use of intravenous (IV) tranexamic acid (TXA) in patients undergoing primary bone-patella tendon-bone (BTB) ACLR with...

A Clinical Trial of a Video Intervention Targeting Opioid Disposal After General Surgery: A Feasibility Study.

Feb 04, 2021

The opioid epidemic continues and although some initiatives have shown promise in reducing the number of opiates prescribed, few studies have focused on education of general surgery patients about hom...

Systematic Review and Meta-Analysis of the Association Between Non-Steroidal Anti-Inflammatory Drugs and Operative Bleeding in the Perioperative Period.

Feb 01, 2021

It is increasingly recognized that non-opioid analgesia important analgesia in the perioperative period. Specifically, NSAIDs (nonsteroidal anti-inflammatory drugs) have been touted as an adjunct or e...

Pain Management Strategies Following Anterior Cruciate Ligament Reconstruction - A Systematic Review with Network Meta-Analysis.

Feb 01, 2021

The purpose of this study is to systematically review the randomized controlled trials (RCTs) that evaluate various pain control interventions post-anterior cruciate ligament reconstruction (ACLR), in...