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Asthma

Anti-Asthmatic Adverse Drug Events Quadrupled in Past Decade

Jul 05, 2022

Adverse drug events due to anti-asthmatic medications have been substantially rising during the past two decades among younger children. Studies have shown that asthma medication adherence is b...

FeNO Testing Effective as Diagnostic Tool in Urban Setting

Jun 08, 2022

Initial and consistent fractured exhaled nitric oxide measurements can help identify asthma-related morbidity in children living in urban areas.   Asthma affects every age group, gender, ra...

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank.

May 23, 2022

The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect ...

Analysis of risk factors for postoperative complications in non-small cell lung cancer: comparison with the Japanese National Clinical Database risk calculator.

May 16, 2022

Although the risk calculator of the National Clinical Database (RC-NCD) has been widely used to predict the occurrence of mortality and major morbidity in Japan, it has not been demonstrated whether a...

The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease.

Mar 14, 2022

The respiratory tract is home to a diverse microbial community whose influence on local and systemic immune responses is only beginning to be appreciated. Increasing reports have linked changes in thi...

Oral Immunotherapy Efficacious for Childhood FA

Feb 23, 2022

“Childhood food allergy (FA) is steadily increasing globally and represents a serious public health problem for the 3% to 8% children affected,” explains Antonella Muraro, MD, PhD. “FA is also t...

Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung inflammation.

Feb 21, 2022

It has recently emerged that drugs such as the mTOR inhibitor rapamycin (Rapa) may play a key role in the treatment of airway inflammation associated with lung diseases, such as chronic obstructive pu...

Associations of early-life pet ownership with asthma and allergic sensitization: a meta-analysis of >77,000 children from the EU Child Cohort Network.

Feb 14, 2022

Studies examining associations of early-life cat and dog ownership with childhood asthma have reported inconsistent results. Several factors could explain these inconsistencies, including type of pet,...

Diverse Diet in First Year of Life May Cut Risk of Allergic Diseases

Feb 01, 2022

“Diet is a crucial environmental factor in early life that impacts the development of allergic diseases,” explains Nianhong Yang, MD. However, research regarding the relationship between diet dive...

Work environment, occupational diseases and accidents among seafood industry workers in Greenland.

Jan 31, 2022

The seafood industry is the largest industry in Greenland. Work-related diseases and accidents appear to constitute health risks in this sector. The aim was to describe the prevalence of work-related ...

Association between asthma control trajectories in preschoolers and long-term asthma control.

Jan 24, 2022

The potential influence of asthma control in early life on long-term outcomes in childhood remains largely unknown.To examine whether asthma control trajectories in the 2 years post-diagnosis in presc...

Association of Neighborhood Characteristics with Pediatric Asthma.

Jan 17, 2022

To examine associations between neighborhood characteristics and asthma prevalence and severity among low-income children in a large nationally representative sample.Data source: 2018 National Survey ...

Helminth infections and allergic diseases: systematic review and meta-analysis of the global literature.

Jan 03, 2022

There is considerable research interest in the role of helminth infections in the development of allergic diseases. However, findings from previous studies are mixed. Existing systematic reviews of th...

Leukotriene C synthase is a novel PPARγ target gene, and leukotriene C and D activate adipogenesis through cysteinyl LT1 receptors in adipocytes.

Jan 03, 2022

Leukotriene (LT) C synthase (LTC4S) catalyzes the conversion from LTA to LTC which is a proinflammatory lipid mediator in asthma and other inflammatory diseases. LTC is metabolized to LTD and LTE, all...

Mepolizumab Is an Effective Option in Severe Eosinophilic Asthma Regardless of Baseline Features: Single-Center Real-Life Data.

Dec 20, 2021

Mepolizumab has been approved as a treatment option for severe eosinophilic asthma (SEA) patients in our country. We aimed to evaluate the clinical and functional efficacy of mepolizumab in this group...

Wireless Wearable Ultrasound Sensor to Characterize Respiratory Behavior.

Nov 29, 2021

A wireless wearable sensor on a paper substrate was used to continuously monitor respiratory behavior that can extract and deliver clinically relevant respiratory parameters to a smartphone. Intended ...

Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes.

Nov 08, 2021

Developing functional insight into the causal molecular drivers of immunological disease is a critical challenge in genomic medicine. Here, we systematically apply Mendelian randomization (MR), geneti...

Childhood Food Allergy, Sensitivity & Adult Airways Disease

Oct 28, 2021

We’ve long known that childhood food allergy and food allergen sensitization are associated with asthma and rhinitis in childhood. However, the associations between childhood food allergy/food aller...

Issues affecting young people with asthma through the transition period to adult care.

Oct 25, 2021

Asthma is among the most common medical conditions affecting children and young people, with adolescence a recognised period of increased risk, overrepresented in analyses examining recent increasing ...

Effect of the Fungal Immunomodulatory Protein FIP-fve in the Neutrophilic Asthma Animal Model.

Oct 18, 2021

Asthma animal models provide valuable information about the pathogenesis and the treatment of asthma. An ovalbumin (OVA)/complete Freund's adjuvant (CFA)-sensitized model was developed to induce neutr...