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Asthma

Health effects associated with proximity to waste collection points in Beitbridge Municipality, Zimbabwe.

Mar 09, 2020

Population growth, urbanisation and economic development have led to the increasing generation of municipal solid waste while environmentally sustainable management remains a challenge the world over....

Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank.

Mar 09, 2020

Pediatric asthma remains a public health challenge with enormous impact worldwide.The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to ...

Asthma, Chronic Obstructive Pulmonary Disease, and Subsequent Risk for Incident Rheumatoid Arthritis among Women: A Prospective Cohort Study.

Mar 05, 2020

Inflamed airways are hypothesized to contribute to rheumatoid arthritis (RA) pathogenesis due to RA-related autoantibody production, and smoking is the strongest environmental RA risk factor. However,...

IL-4/IL-13 upregulates Sonic hedgehog expression to induce allergic airway epithelial remodeling.

Mar 05, 2020

We have previously demonstrated that upregulation of Sonic hedgehog (SHH) expression in allergic airway epithelia essentially contributes to the goblet cell metaplasia and mucous hypersecretion. Howev...

2020 Brazilian Thoracic Association recommendations for the management of asthma.

Mar 05, 2020

The pharmacological management of asthma has changed considerably in recent decades, as it has come to be understood that it is a complex, heterogeneous disease with different phenotypes and endotypes...

Association between C-reactive protein and mood disorder in a representative sample of the Canadian population: analysis of CHMS data 2013-2014.

Mar 05, 2020

The inflammatory biomarker C-reactive protein (CRP) measures systemic inflammation and has been shown to be increased in patients with mood disorders such as depression. The objective of this study wa...

IL-9 exerts biological function on antigen-experienced murine T cells and exacerbates colitis induced by adoptive transfer.

Mar 05, 2020

IL-9 is involved in various T cell-dependent inflammatory models including colitis, encepahlitis and asthma. However, the regulation and specificity of IL-9 responsiveness by T cells during immune res...

PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma.

Mar 02, 2020

Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC ins...

Asthma Across Childhood: Improving Adherence to Asthma Management from Early Childhood to Adolescence.

Mar 02, 2020

Asthma affects nearly 6 million US children. Throughout childhood, children undergo a series of biological, developmental, and psychosocial changes. Thus, factors influencing a child's asthma manageme...

Asthma-Related ED Visits in Children With Depression & Anxiety

Feb 21, 2020

Research indicates that adults with asthma as well as depression, anxiety, or both demonstrate higher asthma-related healthcare use, including emergency department (ED) visits. Naomi S. Bardach, MD, M...

TLR5 Activation Exacerbates Airway Inflammation in Asthma.

Feb 17, 2020

Innate immune activation through exposure to indoor and outdoor pollutants is emerging as an important determinant of asthma severity. For example, household levels of the bacterial product lipopolysa...

Recent findings in the genetics and epigenetics of asthma and allergy.

Feb 17, 2020

In asthma and allergy genetics, a trend towards a few main topics developed over the last 2 years. First, a number of studies have been published recently which focus on overlapping and/or very speci...

Sex Difference Between Trace Elements and Pulmonary Functions in Children.

Feb 17, 2020

It has been defined that deficiency of trace elements plays an important role in the progression of asthma. However, the relationship between blood zinc (Zn), selenium (Se), and magnesium (Mg) and pul...

Antidepressant Target Dose Optimization and Control of Severe Asthma Exacerbations in Uninsured and Underinsured Patients with Anxiety and/or Depression.

Feb 17, 2020

Generalized anxiety disorder (GAD) and major depressive disorder (MDD) are prevalent in patients with asthma. These disorders may increase asthma severity and decrease asthma control. No studies have ...

Adverse pregnancy outcomes and risk of later allergic rhinitis - Nationwide Swedish cohort study.

Feb 17, 2020

Perinatal conditions may be associated with future allergic disease; however, data are conflicting and incomplete for childhood allergic rhinitis (AR). The aim of this study was to examine pregnancy o...

Value of bronchial reversibility to salbutamol, exhaled nitric oxide and responsiveness to methacholine to corroborate the diagnosis of asthma in children.

Feb 13, 2020

Functional and inflammatory measures have been recommended to corroborate asthma diagnosis in schoolchildren, but the evidence in this regard is conflicting. We aimed to determine, in real-life clinic...

Lepidopterism: Case Report and Review of the Literature

Feb 13, 2020

Lepidopterism is a term that refers to a spectrum of medical conditions, typically involving the skin, that result from contact with the adult or larval forms of certain butterflies and moths. There ...

Quantitative proteomics analysis of the treatment of asthma rats with total flavonoid extract from chamomile.

Feb 13, 2020

Asthma is a chronic immune disease that has become a serious public health problem. The currently available medications are not ideal because of their limitations and side effects; hence, new target p...

Different effects of acetyl-CoA carboxylase inhibitor TOFA on airway inflammation and airway resistance in a mice model of asthma.

Feb 13, 2020

Acetyl CoA carboxylase (ACC) regulates the differentiation of Th1, Th2, Th17 cells and Treg cells, which play a critical role in airway inflammation of asthma. Here we investigated the role of ACC in ...

Temporal condition pattern mining in large, sparse electronic health record data: A case study in characterizing pediatric asthma.

Feb 13, 2020

This study introduces a temporal condition pattern mining methodology to address the sparse nature of coded condition concept utilization in electronic health record data. As a validation study, we ap...

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