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Asthma

Issues affecting young people with asthma through the transition period to adult care.

Oct 25, 2021

Asthma is among the most common medical conditions affecting children and young people, with adolescence a recognised period of increased risk, overrepresented in analyses examining recent increasing ...

Effect of the Fungal Immunomodulatory Protein FIP-fve in the Neutrophilic Asthma Animal Model.

Oct 18, 2021

Asthma animal models provide valuable information about the pathogenesis and the treatment of asthma. An ovalbumin (OVA)/complete Freund's adjuvant (CFA)-sensitized model was developed to induce neutr...

Small Airway Susceptibility to Chemical and Particle Injury.

Oct 18, 2021

Small airways (SA) in humans are commonly defined as those conducting airways <2 mm in diameter. They are susceptible to particle- and chemical-induced injury and play a major role in the developme...

Ethnic differences in severe asthma clinical care and outcomes: an analysis of United Kingdom primary and specialist care.

Oct 11, 2021

Understanding the effects of ethnicity in severe asthma is important for optimal personalised patient care.To assess ethnic differences in disease control, exacerbations, biological phenotype and trea...

Increased hospital admissions for asthma from short-term exposure to cold spells in Beijing, China.

Sep 13, 2021

There is a paucity of studies investigating extreme cold events and asthma exacerbations. This study examined whether an association exists between cold spells and daily hospital admissions for asthma...

Practicing What We Teach: Increasing Inhaler Use for Mild Asthma in the Pediatric Emergency Department.

Sep 13, 2021

Asthma is a leading cause of pediatric emergency department (ED) visits. A metered-dose inhaler and spacer (MDI-S) device is equivalent to and more cost effective than delivery by nebulization in the ...

Atopic Dermatitis Linked With Greater Risk of Health Care Utilization for Asthma

Aug 27, 2021

While the occurrence of concomitant asthma and atopic dermatitis (AD) in patients is well known, the impact of the causal relationship between asthma and AD is not fully understood. Furthermore, data ...

Long term exposure to air pollution, mortality and morbidity in New Zealand: Cohort study.

Aug 26, 2021

To investigate associations between long-term exposure to PM, NO, mortality and morbidity in New Zealand, a country with low levels of exposure.Retrospective cohort study.The New Zealand resident popu...

E-cigarette use and adverse respiratory symptoms among adolescents and Young adults in the United States.

Aug 23, 2021

E-cigarette use among adolescents and young adults has been associated with adverse respiratory symptoms, including symptoms of asthma and bronchitis. This investigation examined whether such associat...

Relaxation Effect of Lignans on the Isolated Tracheal Smooth Muscle in Rats and Its Mechanism.

Aug 19, 2021

() is one of the core drugs used for relieving cough and asthma in traditional Chinese medicine. However, there are few basic studies on the treatment of respiratory diseases with in modern pharmaco...

Can bronchial challenge test with adenosine or methacholine at preschool age predict school-age asthma?

Aug 19, 2021

Bronchial challenge test (BCT) measures current airways-hyperreactivity, however, its predictive role in pre-school children (<6 years) for the diagnosis of asthma at school age is still debatable....

Symptom control in patients with asthma using inhaled corticosteroids/long-acting β-agonists (fluticasone furoate/vilanterol or budesonide/formoterol) in the US: a retrospective matched cohort study.

Aug 12, 2021

Treatment with fluticasone furoate/vilanterol (FF/VI), an inhaled corticosteroid/long-acting β-agonist therapy, reduces the risk of severe asthma exacerbations and improves lung function and symptom...

Evidence for causal associations between prenatal and postnatal antibiotics exposure and asthma in children, England.

Aug 09, 2021

Higher risks of asthma have been observed in children with prenatal exposure to antibiotics and during early life compared to those who have not. However, the causality of such associations is unclear...

Indacaterol, glycopyrronium, and mometasone: pharmacological interaction and anti-inflammatory profile in hyperresponsive airways.

Aug 09, 2021

LABA/ICS and LABA/LAMA/ICS combinations elicit beneficial effects in asthma. Specific evidence concerning the impact of combining indacaterol acetate (IND), glycopyrronium bromide (GLY), and mometason...

Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis (EGPA): a European multicenter observational study.

Aug 05, 2021

Mepolizumab proved efficacious for eosinophilic granulomatosis with polyangiitis (EGPA, former Churg-Strauss) at the dosage of 300mg/4 weeks in the randomized controlled MIRRA trial. Few successful re...

Blood eosinophil count and FeNO to predict benralizumab effectiveness in real-life severe asthma patients.

Aug 05, 2021

Benralizumab is a promising drug for severe uncontrolled asthma. This study aimed to clarify the effectiveness of benralizumab in a real-life setting. Subjects included 24 patients with severe type 2...

Major Depressive Disorder Enhances Th2 and Th17 Cytokines in Patients Suffering from Allergic Rhinitis and Asthma.

Aug 05, 2021

Major depressive disorder (MDD) can impact the severity of allergic rhinitis (AR) and asthma (AA). Here, we evaluated the cytokine production by T-cells from AR and AA patients with or without MDD. Th...

Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk.

Jul 29, 2021

Picornavirus family members cause disease in humans. Human rhinoviruses (RV), the main causative agents of the common cold, increase the severity of asthma and COPD; hence, effective agents against RV...

Metformin use and risk of asthma exacerbation among asthma patients with glycemic dysfunction.

Jul 26, 2021

Diabetes is associated with worse asthma morbidity. Metformin, which treats diabetes, may have a role among patients with asthma and glycemic dysfunction.To determine the association between metformin...

Development of a Health Disparities Index: Proof of Concept with Chest Radiography in Asthma.

Jul 22, 2021

To develop a tool for quantifying health disparity (Health Disparity Index, HDI) and explore hospital variation measured by this index using chest radiography (CXR) in asthma as the proof of concept.R...

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