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Autism

It feels like sending your children into the lions' den" - A qualitative investigation into parental attitudes towards ASD inclusion, and the impact of mainstream education on their.

Nov 29, 2021

Increasing numbers of autistic children are being educated in mainstream schools. The success of inclusive education is dependent upon multiple factors, including key stakeholders (i.e., teachers and ...

Intensity, dynamics and deficiencies of empathy in medical and non-medical students.

Sep 13, 2021

Empathy is an important competence in the professional development of medical students. The purpose of our study was to compare the levels and scales of empathy in people studying in different educati...

Translation, validation and cross-cultural adaptation of the Malay emotion regulation checklist (ERC-M): A preliminary study.

Sep 13, 2021

Emotion Regulation Checklist (ERC) has been used globally and translated to several languages, including Brazilian Portuguese, Italian and Persian. The aim of this study is to translate and validate E...

Deletion of the sodium/hydrogen exchanger 6 causes low bone volume in adult mice.

Sep 13, 2021

The sodium/hydrogen exchanger 6 (NHE6) localizes to recycling endosomes, where it mediates endosomal alkalinization through K/H exchange. Mutations in the SLC9A6 gene encoding NHE6 cause severe X-link...

An ethical analysis of divergent clinical approaches to the application of genetic testing for autism and schizophrenia.

Aug 30, 2021

Genetic testing to identify genetic syndromes and copy number variants (CNVs) via whole genome platforms such as chromosome microarray (CMA) or exome sequencing (ES) is routinely performed clinically,...

Shank3 Deficiency is Associated With Altered Profile of Neurotransmission Markers in Pups and Adult Mice.

Aug 30, 2021

Alterations in the balance between excitation and inhibition, especially in the brain's critical developmental periods, are considered an integral part of the pathophysiology of autism. However, the p...

Phenanthrene induces autism-like behavior by promoting oxidative stress and mTOR pathway activation.

Aug 30, 2021

Autism is thought to be associated with both environmental and genetic factors. Phenanthrene (Phe) makes up a relatively high proportion of the low-ring polycyclic aromatic hydrocarbons. However, the ...

Multi-PheWAS intersection approach to identify sex differences across comorbidities in 59 140 pediatric patients with autism spectrum disorder.

Aug 19, 2021

To identify differences related to sex and define autism spectrum disorder (ASD) comorbidities female-enriched through a comprehensive multi-PheWAS intersection approach on big, real-world data. Altho...

Ethical dimensions of translational developmental neuroscience research in autism.

Aug 19, 2021

Since the 1990s, increasing research has been devoted to the identification of biomarkers for autism to help attain more objective diagnosis; enable early prediction of prognosis; and guide individual...

Transcriptome programs involved in the development and structure of the cerebellum.

Aug 19, 2021

In the past two decades, mounting evidence has modified the classical view of the cerebellum as a brain region specifically involved in the modulation of motor functions. Indeed, clinical studies and ...

Air pollution and autism spectrum disorder in Israel: A negative control analysis.

Aug 05, 2021

Residual confounding is a major concern for causal inference in observational studies on air pollution-autism spectrum disorder (ASD) associations. This study is aimed at assessing confounding in thes...

Severe deficiency of the voltage-gated sodium channel Na1.2 elevates neuronal excitability in adult mice.

Aug 05, 2021

Scn2a encodes the voltage-gated sodium channel Na1.2, a main mediator of neuronal action potential firing. The current paradigm suggests that Na1.2 gain-of-function variants enhance neuronal excitabil...

Paradoxical hyperexcitability from Na1.2 sodium channel loss in neocortical pyramidal cells.

Aug 05, 2021

Loss-of-function variants in the gene SCN2A, which encodes the sodium channel Na1.2, are strongly associated with autism spectrum disorder and intellectual disability. An estimated 20%-30% of children...

Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.

Jun 24, 2021

In 2017, facing lack of progress and failures encountered in targeted drug development for Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM with the ECNP created the ...

Association between autism spectrum disorder and changes in the central auditory processing in children.

Jun 24, 2021

To verify the scientific evidence on the association between Autistic Spectrum Disorder and Central Auditory Processing Disorder in children, aiming to answer the following research question: What is ...

The functional neural architecture of dysfunctional reward processing in autism.

Jun 24, 2021

Functional imaging studies have found differential neural activation patterns during reward-paradigms in patients with autism spectrum disorder (ASD) compared to neurotypical controls. However, public...

Survey for caregivers of people in the autism spectrum in Chile: first concerns, age of diagnosis and clinical characteristics.

Jun 10, 2021

Autism Spectrum Disorders (ASD) are neurodevelopmental disorders of increasing prevalence. People with ASD have multiple health, education, and community needs, yet there is little information about t...

Pivotal Response Treatment with and without robot-assistance for children with autism: a randomized controlled trial.

Jun 10, 2021

Pivotal response treatment (PRT) is a promising intervention focused on improving social communication skills in children with autism spectrum disorder (ASD). Since robots potentially appeal to childr...

Efficacy and safety of massage therapy for autism spectrum disorders: A protocol for systematic review and meta-analysis.

Jun 10, 2021

Autism spectrum disorder is a neurodevelopmental disorder with increasing incidence. At present, the global incidence of the disease is on the rise, and the cause is unknown. There is no specific trea...

Unsupervised Machine Learning for Identifying Challenging Behavior Profiles to Explore Cluster-Based Treatment Efficacy in Children With Autism Spectrum Disorder: Retrospective Data Analysis Study.

Jun 03, 2021

Challenging behaviors are prevalent among individuals with autism spectrum disorder; however, research exploring the impact of challenging behaviors on treatment response is lacking.The purpose of thi...