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Back Pain

From the Physician Editor-in-Chief - Chronic Pain: We Need to Ask “Why?”

May 31, 2022

According to the CDC, there are approximately 50 million people in the US living in chronic pain. We all know about the opioid crisis, and this knowledge has done nothing to help alleviate pain many a...

Ultrasound-guided genicular nerves block: an analgesic alternative to local infiltration analgesia for total knee arthroplasty: A noninferiority, matched cohort study.

May 27, 2021

Standard analgesic strategies for total knee arthroplasty employ local infiltration analgesia. Blockade and radiofrequency ablation of the genicular nerves are effective treatments for patients with c...

The Use of Skin Staples as Fiducial Markers to Confirm Intraoperative Spinal Navigation Registration and Accuracy.

May 27, 2021

With the advent of intraoperative computed tomography (CT) for image guidance, numerous examples of accurate navigation being applied to cranial and spinal pathology have come to light. For spinal dis...

GIT1 protects traumatically injured spinal cord by prompting microvascular endothelial cells to clear myelin debris.

Feb 25, 2021

The clearance of myelin debris is a critical step in the functional recovery following spinal cord injury (SCI). As phagocytes do, microvascular endothelial cells (MECs) participate in myelin debris c...

Opioid Mortality Following Implementation of Medical Cannabis Programs in the United States.

Feb 25, 2021

The United States is in the midst of an opioid overdose epidemic. Emerging evidence suggests that medical cannabis (MC) may reduce use of opioids for pain in some individuals, with potential impacts o...

No Association of Plantar Aponeurosis Stiffness with Medial Longitudinal Arch Stiffness.

Feb 25, 2021

Lower stiffness of the medial longitudinal arch is reportedly a risk factor for lower leg disorders. The plantar aponeurosis is considered essential to maintaining the medial longitudinal arch. It is ...

Multi-scale network imaging in a mouse model of amyloidosis.

Feb 22, 2021

The adult neocortex is not hard-wired but instead retains the capacity to reorganise across multiple spatial scales long into adulthood. Plastic reorganisation occurs at the level of mesoscopic sensor...

Evaluation of an emergency department-based opioid overdose survivor intervention: Difference-in-difference analysis of electronic health record data to assess key outcomes.

Feb 22, 2021

In recent years, a number of emergency department (ED)-based interventions have been developed to provide supports and/or treatment linkage for people who use opioids. However, there is limited resear...

Characterizing inter-limb synchronization after incomplete spinal cord injury: A cross-sectional study.

Feb 22, 2021

Individuals with incomplete spinal cord injury (iSCI) demonstrate greater postural sway and increased dependency on vision to maintain balance compared to able-bodied individuals. Research on standing...

Inhibition of ERK1/2 Phosphorylation attenuates Spinal Cord Injury Induced Astrocyte Activation and Inflammation through Negatively regulating Aquaporin-4 in Rats.

Feb 18, 2021

The extracellular signal-regulated kinase (ERK) pathway has been reported to play a pivotal role in mediating spinal cord injury (SCI) progression. The present study aimed to investigate the effects o...

Meta-analysis of outcomes after intentional coverage of celiac artery in thoracic endovascular aortic repair.

Feb 18, 2021

The aim of this study was to demonstrate clinical outcomes of intentional coverage of celiac artery (CA) during thoracic endovascular aneurysm repair (TEVAR).MEDLINE, EMBASE, and Cochrane Library were...

Intermittent REM sleep deprivation attenuates the development of morphine tolerance and dependence in male rats.

Feb 18, 2021

Opioid agonists are used in clinic for pain management, however this application is challenged by development of tolerance and dependence following prolonged exposure. Various approaches have been sug...

Motor unit reserve capacity in spinal muscular atrophy during fatiguing endurance performance.

Feb 15, 2021

To investigate the availability of any motor unit reserve capacity during fatiguing endurance testing in patients with spinal muscular atrophy (SMA).We recorded surface electromyography (sEMG) of vari...

Carfentanil - from an animal anesthetic to a deadly illicit drug.

Feb 15, 2021

The use of novel synthetic opioids as recreational drugs has become a public health concern as they are implicated in numerous fatal intoxications across the world. Synthetic opioids have played a maj...

Relationship between serum nutritional factors and bone mineral density: a Mendelian randomization study.

Feb 15, 2021

Multiple risk factors have been implicated in the development of osteoporosis. This study examined potential associations between serum nutritional factors and bone mineral density (BMD).Six nutrition...

Muscle endurance and cervical electromyographic activity during submaximal efforts in women with and without migraine.

Feb 11, 2021

Despite previous reports supporting cervical muscle weakness and altered motor control in migraine, the endurance under standardized submaximal loads has not been investigated. Therefore, this study a...

Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption.

Feb 11, 2021

Tizanidine is an alpha2-adrenergic agonist, used to treat spasticity associated with multiple sclerosis and spinal injury. Tizanidine is primarily metabolized by CYP1A2 and is considered a sensitive i...

The Effect of Preoperative Opioid Education on Opioid Consumption After Outpatient Orthopedic Surgery: A Prospective Randomized Trial.

Feb 11, 2021

Pain management and opioid consumption following outpatient orthopedic surgery may be influenced by several variables, including knowledge of safe opioid use. A prospective randomized study was undert...

Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress.

Feb 08, 2021

The herbicide aclonifen is commonly used in agriculture. Aclonifen is toxic to experimental animals, causing developmental abnormalities, decreased energy production for survival, and impaired organog...

Consistent differences in lumbar spine alignment between low back pain subgroups and genders during clinical and functional activity sitting tests.

Feb 08, 2021

Subgroups of people with low back pain display differences in their lumbar alignment during tests from a clinical examination. However, it is unknown if subgroups display the same patterns during a fu...