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Diabetes

Obesity-induced TRB3 negatively regulates Brown adipose tissue function in mice.

Feb 18, 2021

Brown adipose tissue (BAT) and stimulating adaptive thermogenesis have been implicated as anti-obese and anti-diabetic tissues due to their ability to dissipate energy as heat by the expression of UCP...

Increasing impacts of temperature on hospital admissions, length of stay, and related healthcare costs in the context of climate change in Adelaide, South Australia.

Feb 18, 2021

A growing number of studies have investigated the effect of increasing temperatures on morbidity and health service use. However, there is a lack of studies investigating the temperature-attributable ...

Trends in ischemic stroke outcomes in a rural population in the United States.

Feb 18, 2021

The stroke mortality rate has gradually declined due to improved interventions and controlled risk factors. We investigated the associated factors and trends in recurrence and all-cause mortality in i...

Anthropometric indices and cardiometabolic risk factors in a Ghanaian adolescent population.

Feb 15, 2021

Adolescent overweight and obesity is a public health concern globally, especially in lower- and middle- income countries where there is an additional burden of undernutrition. The prevalence of adole...

Relationship of acanthosis nigricans with metabolic syndrome in obese children.

Feb 15, 2021

Acanthosis nigricans is a skin symptom in obesity that helps to identify patients at high risk for dyslipidemia, hypertension, insulin resistance, and diabetes. It is the most important complication o...

Glycated hemoglobin variability and microvascular complications in patients with type 1 diabetes mellitus.

Feb 15, 2021

Glycated hemoglobin (HbA1c) has proven to be indicative in the development of microvascular complications. In this study, the contribution of HbA1c variability to microvascular complications was evalu...

The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis.

Feb 11, 2021

The prevalence of obesity is increasing globally and is associated with many metabolic disorders, such as type 2 diabetes and cardiovascular diseases. In recent years, a number of studies suggest that...

Discovering symptom patterns of COVID-19 patients using association rule mining.

Feb 11, 2021

The COVID-19 pandemic is a significant public health crisis that is hitting hard on people's health, well-being, and freedom of movement, and affecting the global economy. Scientists worldwide are com...

The effect of the anti-diabetic drug metformin on musculoskeletal pain: a cross-sectional study with 21,889 individuals from the UK Biobank.

Feb 11, 2021

Although metformin there is growing evidence of metformin's pleiotropic effects, including possible effects on pain, there is a lack of study investigating the association of metformin with the preval...

Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.

Feb 08, 2021

We previously identified a novel series of indolinylpyrimidine derivatives exemplified by 2 in Figure 1, which is an indoline based derivative, as potent GPR119 agonists. Despite the attractive potenc...

Real world study of short term efficacy, safety, and tolerability of canagliflozin 100 mg initiation in type 2 diabetes mellitus patients during hot humid Indian summer.

Feb 08, 2021

To assess short term (3 months) efficacy, safety, and tolerability of canagliflozin 100 mg among type 2 diabetes mellitus (T2DM) initiated during hot humid Indian summer.A prospective, observational,...

Overexpression of Serum Micro-RNA 152-3p in Type 2 Diabetes Mellitus with a Significant Elevation in Progressive Nephropathy.

Feb 08, 2021

Modulation of the immune inflammatory system has been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN); nevertheless, many of the underlying mechanisms a...

Involving Youth in Decision to Initiate CGM Device Use Improves Treatment Adherence

Feb 05, 2021

Involving children and adolescents in the decision to initiate the use of a continuous glucose monitoring (CGM) device is necessary to achieve maximum clinical benefit, explains Victoria A. Miller, Ph...

Long-term mortality after renal artery stenting in patients with severe atherosclerotic renal artery stenosis and high-risk clinical manifestations.

Feb 04, 2021

Atherosclerotic renal artery stenosis is a risk factor for cardiovascular death. Observational studies support the benefit of renal revascularization on outcomes in selected patients with high-risk cl...

Diabetes Care During COVID-19 Pandemic in Singapore Using a Telehealth Strategy.

Feb 04, 2021

Singapore currently has one of highest number of confirmed COVID-19 cases in Southeast Asia. To curb the further spread of COVID-19, Singapore government announced a temporary nationwide lockdown (cir...

Prevention of Gestational Diabetes: The Role of Dietary Intake, Physical Activity, and Weight before, during, and between Pregnancies.

Feb 04, 2021

Gestational diabetes mellitus (GDM) is the most common complication of pregnancy and a significant clinical and public health problem with lifelong and intergenerational adverse health consequences fo...

Comparative Effectiveness of Roux-en Y Gastric Bypass Versus Vertical Sleeve Gastrectomy for Sustained Remission of Type 2 Diabetes Mellitus.

Feb 01, 2021

Bariatric surgery results in rapid weight loss and resolution of comorbidities such as type 2 diabetes mellitus (T2DM). We aimed to determine whether the type of surgical procedure-vertical sleeve gas...

Seizure is a rare presenting manifestation of COVID-19.

Feb 01, 2021

The aim of the current study was to investigate whether seizure is among the presenting manifestations of COVID-19.All patients referred to emergency rooms anywhere in Iran between 12 and 25 April 202...

Glucose regulation and grip strength in adults: Findings from the Helsinki Birth Cohort Study.

Feb 01, 2021

This study aimed to assess the association between grip strength and glucose regulation in a cross-sectional setting.Using data from the Helsinki Birth Cohort Study, 924 men and 953 women were studied...

Role of Oxidative Stress and Severity of Diabetic Retinopathy in Type 1 & Type 2 Diabetes.

Jan 28, 2021

Diabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus (DM). Oxidative stress generated on account of hyperglycemic state may lead to retinal abnormalities including DR.To ...