Advertisement

Flu

[Prediction of inhibition of influenza virus neuraminidase of various strains by using a generalized model constructed using the data on the position of known ligands].

Dec 31, 2020

Several variants of models for predicting the IC50 values of inhibitors of influenza virus neuraminidase are presented for both individual strains and for combinations of data for neuraminidases of se...

Characterization of commercial poultry farms in Mexico: Towards a better understanding of biosecurity practices and antibiotic usage patterns.

Dec 03, 2020

Mexico is one of the world's major poultry producing countries. Two significant challenges currently facing the poultry industry are the responsible and judicious use of antimicrobials, and the potent...

Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study.

Nov 30, 2020

To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all ...

Triterpenoid-Mediated Inhibition of Virus-Host Interaction: Is Now the Time for Discovering Viral Entry/Release Inhibitors from Nature?

Nov 19, 2020

Fatal infectious diseases caused by HIV-1, influenza A virus, Ebola virus, and currently pandemic coronavirus highlight the great need for the discovery of antiviral agents in mechanisms different fro...

Systematic review and meta-analysis of the prevalence of common respiratory viruses in children < 2 years with bronchiolitis in the pre-COVID-19 pandemic era.

Nov 16, 2020

The advent of genome amplification assays has allowed description of new respiratory viruses and to reconsider the role played by certain respiratory viruses in bronchiolitis. This systematic review a...

Respiratory pathogen diversity and co-infections in rural Zambia.

Nov 02, 2020

The role of respiratory co-infections in modulating disease severity remains understudied in southern Africa, particularly in rural areas. We characterized the spectrum of respiratory pathogens in rur...

Descriptive study of sickness absence in Spanish regions in 2018: database study.

Nov 02, 2020

To provide a wide and thorough description of sickness absence (SA) in Spain, focussing on the different regions of the country and the main characteristics of SA.A study of the SA spells in Spain, ma...

Plain Language Summaries of Clinical Trial Results: A Preliminary Study to Assess Availability of Easy-to-Understand Summaries and Approaches to Improving Public Engagement.

Oct 29, 2020

Easy-to-understand, stand-alone factual summaries of clinical trial results have the potential to improve public understanding of and engagement with pharmaceutical research. The European Clinical Tri...

COVID-19, varying genetic resistance to viral disease, and immune tolerance checkpoints.

Oct 29, 2020

COVID-19 is a zoonosis like most of the great plagues sculpting human history, from smallpox to pandemic influenza and human immunodeficiency virus. When viruses jump into a new species the outcome of...

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.

Oct 29, 2020

The interferon-induced transmembrane proteins play an important antiviral role by preventing viruses from traversing the cellular lipid bilayer. IFITM3 gene variants have been associated with the clin...

Aspergillosis Complicating Severe Coronavirus Disease.

Oct 22, 2020

Aspergillosis complicating severe influenza infection has been increasingly detected worldwide. Recently, coronavirus disease-associated pulmonary aspergillosis (CAPA) has been detected through rapid ...

An improved multivariate model that distinguishes COVID-19 from seasonal flu and other respiratory diseases.

Oct 22, 2020

COVID-19 shared many symptoms with seasonal flu, and community-acquired pneumonia (CAP) Since the responses to COVID-19 are dramatically different, this multicenter study aimed to develop and validate...

Strategies for Addressing Influenza Vaccination Hesitancy With Patients

Sep 30, 2020

Although many patients are aware of the risks associated with influenza, they may still be hesitant about getting the flu vaccine each year. CDC data indicates that only 49% of Americans received a fl...

Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.

Sep 24, 2020

Cellular exonucleases involved in the processes that regulate RNA stability and quality control have been shown to restrict or to promote the multiplication cycle of numerous RNA viruses. Influenza A ...

Differential diagnosis for suspected cases of coronavirus disease 2019: a retrospective study.

Sep 21, 2020

Since December 2019, the coronavirus disease 2019 (COVID-19) has infected more than 12,322,000 people and killed over 556,000 people worldwide. However, Differential diagnosis remains difficult for su...

Effectiveness of oseltamivir in reduction of complications and 30-day mortality in severe seasonal influenza infection.

Sep 10, 2020

The benefit of oseltamivir treatment in patients admitted with influenza virus infection and the design of studies addressing this issue, have been questioned extensively. Since the influenza disease ...

Punicalagin is a neuraminidase inhibitor of influenza viruses.

Aug 24, 2020

Influenza A virus (IAV) causes great morbidity and mortality worldwide every year. However, there are only a limited number of drugs clinically available against IAV infection. Further, emergence of d...

A diagnostic genomic signal processing (GSP)-based system for automatic feature analysis and detection of COVID-19.

Aug 17, 2020

Coronavirus Disease 2019 (COVID-19) is a sudden viral contagion that appeared at the end of last year in Wuhan city, the Chinese province of Hubei, China. The fast spread of COVID-19 has led to a dang...

Global cataloguing of variations in untranslated regions of viral genome and prediction of key host RNA binding protein-microRNA interactions modulating genome stability in SARS-CoV-2.

Aug 13, 2020

The world is going through the critical phase of COVID-19 pandemic, caused by human coronavirus, SARS-CoV-2. Worldwide concerted effort to identify viral genomic changes across different sub-types has...

Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) viruses.

Aug 06, 2020

Neuraminidase inhibitors (NAIs) are antiviral agents recommended worldwide to treat or prevent influenza virus infections in humans. Past influenza virus pandemics seeded by zoonotic infection by avia...