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Flu

Nephrotic syndrome due to minimal-change disease superimposed on anti-glomerular basement membrane antibody positive glomerulonephritis; a case report.

Jul 20, 2020

The prognosis for renal function in anti-GBM glomerulonephritis (anti-GBM GN) is extremely poor, and when renal impairment progresses severely, it is difficult to expect improvement. In addition, it i...

Cause of death in adults with Down syndrome in the US.

Jul 20, 2020

Prior studies report anomalous cause of death patterns for adults with Down syndrome, but do not provide comparison of age trends for specific causes of death between adults with and without Down synd...

Collective interactions augment influenza A virus replication in a host-dependent manner.

Jul 09, 2020

Infection with a single influenza A virus (IAV) is only rarely sufficient to initiate productive infection. Instead, multiple viral genomes are often required in a given cell. Here, we show that the r...

Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory?

Jul 09, 2020

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has been linked to a higher risk of mortality compared to influenza, which is mainly due to severe secondary diseases, such as ac...

School closure, COVID-19 and lunch programme: Unprecedented undernutrition crisis in low-middle income countries.

Jul 06, 2020

The coronavirus disease 2019 pandemic has affected nearly 70% of children and teenagers around the world due to school closure policies. School closure is implemented widely in order to prevent viral ...

Convergent Evolution in Breadth of Two V6-1-Encoded Influenza Antibody Clonotypes from a Single Donor.

Jul 06, 2020

Understanding how broadly neutralizing antibodies (bnAbs) to influenza hemagglutinin (HA) naturally develop in humans is critical to the design of universal influenza vaccines. Several classes of bnAb...

MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells.

Jun 25, 2020

MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial dam...

TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.

Jun 22, 2020

Tripartite motif (TRIM) family proteins are important effectors of innate immunity against viral infections. Here we identified TRIM35 as a regulator of TRAF3 activation. Deficiency in or inhibition o...

Baloxavir Marboxil Single-dose Treatment in Influenza-infected Children: A Randomized, Double-blind, Active Controlled Phase 3 Safety and Efficacy Trial (miniSTONE-2).

Jun 11, 2020

Baloxavir marboxil (baloxavir) is a novel, cap-dependent endonuclease inhibitor that has previously demonstrated efficacy in the treatment of influenza in adults and adolescents. We assessed the safet...

Development of sustained release Oseltamivir phosphate dry powder inhaler: In-vitro and in-vivo Toxicological Studies.

Jun 01, 2020

Oseltamivir Phosphate (OP) is an ethyl ester prodrug prescribed for the treatment of influenza virus infection. Current marketed formulations of OP supplemented with an adverse effect observed during ...

Influenza-associated mortality in Hungary between 2009/2010 and 2016/2017

May 28, 2020

In recent years, a significant mortality peak has been observed several times during the first months in Hungary. So far, no mortality study clarified the connection between the mortality peaks and in...

Cytokine Storm: The Sudden Crash in Patients with COVID-19

Apr 08, 2020

It's jarring every time. The sudden crash in patients with COVID-19 All over the world, seemingly mild cases of COVID-19 rapidly morph into severe cases that involve the lower lungs. This may b...

New guidelines on caring for ICU patients with COVID-19

Apr 07, 2020

International panel does quick turnaround McMaster University Hamilton, ON (April 1, 2020) - An international team including McMaster University researchers has come together to issue guidelines for...

Subtype diversity of influenza A virus in North American waterfowl: a multi-decade study.

Mar 20, 2020

The discovery in 1976 of waterfowl as the primary reservoir of influenza A viruses (IAV) has since spurred decades of waterfowl surveillance efforts by researchers dedicated to understanding the ecolo...

Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms.

Mar 20, 2020

Enveloped viruses enter cells via a process of membrane fusion between the viral envelope and a cellular membrane. For influenza virus, mutational data have shown that the membrane-inserted portions o...

Human respiratory syncytial virus and influenza seasonality patterns-Early findings from the WHO global respiratory syncytial virus surveillance.

Mar 13, 2020

Human respiratory syncytial virus (RSV) causes illnesses among all age groups and presents a burden to healthcare services. To better understand the epidemiology and seasonality of RSV in different ge...

Adeno-associated virus-vectored influenza vaccine elicits neutralizing and Fcγ receptor-activating antibodies.

Mar 13, 2020

The current seasonal inactivated influenza vaccine protects only against a narrow range of virus strains as it triggers a dominant antibody response toward the hypervariable hemagglutinin (HA) head re...

Multicenter evaluation of the QIAstat Respiratory Panel-A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections.

Mar 13, 2020

Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical car...

Environmental complex exposure and the risk of influenza-like illness among housewives: A case study in Shanxi Province, China.

Mar 13, 2020

The association between environmental pollution and risk of influenza-like illness (ILI) among general population has been reported. However, the relationships between the individual pollutants and IL...

The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections.

Mar 05, 2020

We have engineered a Human Immune System (HIS)-reconstituted mouse strain (DRAGA mouse: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD) in which the murine immune system has been replaced by a long-term, ...