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Opioids

Tracking Assessment Tool Supports Treatment of Opioid Use Disorder in Primary Care

Dec 21, 2021

Despite efforts to curb opioid use disorder (OUD), the epidemic continues to be a major national crisis. Methadone, buprenorphine, and naltrexone are standard of care FDA-approved treatments for OUD, ...

"I Know It Is Going to Ruin Their Life:" Fortune-Telling, Agency, and Harm Reduction in Narratives Concerning Injection Initiation Assistance.

Aug 05, 2021

Considering most people who inject drugs (PWID) received help with the first injection, understanding the perspective of potential 'initiators' is a priority to inform harm reduction interventions. Th...

CME/CE: Assessing Prescription Opioid Medical Use & Misuse in Parents & Offspring

Jul 02, 2021

This course discusses a study that examined associations between parental and adolescent prescription opioid medical use and misuse....

Examining Characteristics Linked With Poor Outcomes in Opioid Prescribing

Jun 30, 2021

“In recent decades, the medical community has become acutely aware of the dangers posed by prescription opioids and their contribution to the opioid epidemic,” explains David R. Foster, PharmD, FC...

Engaging vulnerable populations in drug treatment court: Six month outcomes from a co-occurring disorder wraparound intervention.

Apr 19, 2021

Although drug treatment courts (DTCs) have demonstrated positive outcomes, participants with co-occurring mental health and substance use disorders (CODs) are a high-risk group that often struggle wit...

Trends in substances involved in polysubstance overdose fatalities in Maryland, USA 2003-2019.

Apr 19, 2021

The substances driving the overdose epidemic in the United States have changed over time. Since 2013, fentanyl-analogues have become the primary opioids driving the epidemic. Recently, polysubstance r...

The association of opioid use disorder and homelessness nationally in the veterans health administration.

Apr 19, 2021

Substance use disorder (SUD) is a major risk factor for homelessness, but the specific association of opioid use disorder (OUD) and homelessness in the context of their shared risk factors has not bee...

The Effects of Multimodal Analgesia in Critically Ill Patients With Burns

Mar 29, 2021

Pain from burn injuries can be challenging to treat and remains one of the most severe forms of trauma a patient can endure, explains Sierra R. Young, PharmD, BCCCP.  “Patients with burn injuries e...

CDC's Efforts to Quantify Prescription Opioid Overdose Deaths Fall Short.

Mar 25, 2021

In a 2018 report titled, Quantifying the Epidemic of Prescription Opioid Overdose Deaths, four senior analysts of the Centers for Disease Control and Prevention (CDC), including the head of the Epidem...

Assessing Prescription Opioid Medical Use & Misuse in Parents & Offspring

Mar 22, 2021

According to recent data, nearly 50% of adolescents who misuse prescription opioids report obtaining the drugs from relatives or friends. Understanding the parental origins of adolescent prescription ...

Assessing Perioperative Multimodal Analgesia in Patients With Burns

Mar 03, 2021

Postoperative pain has been shown in prior research to be a major challenge for patients with burns who undergo autologous skin grafting. Burn injuries cause severe pain, with many patients requiring ...

Factor structure and psychometric properties of the Connor-Davidson resilience scale (CD-RISC) in individuals with opioid use disorder.

Feb 25, 2021

Resilience is defined as the capacity for an individual to maintain normal functioning and resist the development of psychiatric disorders in response to stress and trauma. Although previous investiga...

Comparison of psychological symptoms and cognitive functions in patients under maintenance treatment with methadone or buprenorphine, current opioid users and healthy subjects.

Feb 25, 2021

Methadone and buprenorphine can affect the psychological symptoms and cognitive functioning of substance users. This study aimed to compare psychological symptoms and neuropsychological functioning in...

Opioid Mortality Following Implementation of Medical Cannabis Programs in the United States.

Feb 25, 2021

The United States is in the midst of an opioid overdose epidemic. Emerging evidence suggests that medical cannabis (MC) may reduce use of opioids for pain in some individuals, with potential impacts o...

CME: A Closer Look at Patterns in Prescription Opioid Use & Misuse Among Cancer Survivors

Feb 22, 2021

This course discusses a study that analyzed the prevalence of and risk factors for prescription opioid use and misuse in adult cancer survivors and compared patterns with those in people without can...

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.

Feb 22, 2021

Despite major advances, there remains a need for novel anesthetic drugs or drug combinations with improved efficacy and safety profiles. Here, we show that inhibition of cAMP-phosphodiesterase 4 (PDE4...

Effect of suvorexant on morphine tolerance and dependence in mice: Role of NMDA, AMPA, ERK and CREB proteins.

Feb 22, 2021

The major problems of morphine use in the clinic are its tolerance and dependence. This study aimed to investigate the effect of suvorexant, a dual orexin receptor antagonist, on morphine-induced depe...

Evaluation of an emergency department-based opioid overdose survivor intervention: Difference-in-difference analysis of electronic health record data to assess key outcomes.

Feb 22, 2021

In recent years, a number of emergency department (ED)-based interventions have been developed to provide supports and/or treatment linkage for people who use opioids. However, there is limited resear...

Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care.

Feb 18, 2021

Acute low back pain (LBP) is highly prevalent, with a presumed favorable prognosis; however, once chronic, LBP becomes a disabling and expensive condition. Acute to chronic LBP transition rates vary w...

Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: the possible role of μ-opioid receptors and ΔFosB in the brain reward pathway.

Feb 18, 2021

Prenatal opioids exposure negatively affects the neurobehavioral abilities of children born from dependence dams. Adolescent housing conditions can buffer the detrimental impacts of early life experie...