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Addictions

Hippocampal TNF-α Signaling Mediates Heroin Withdrawal-Enhanced Fear Learning and Withdrawal-Induced Weight Loss.

Feb 15, 2021

There is significant comorbidity of opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) in clinical populations. However, the neurobiological mechanisms underlying the relationship bet...

PAIN CATASTROPHIZING, OPIOID MISUSE, OPIOID USE, AND OPIOID DOSE IN PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN: A SYSTEMATIC REVIEW.

Feb 15, 2021

The objective of this study was to analyze the cross-sectional and longitudinal association between pain catastrophizing and opioid misuse, opioid use, and opioid dose in people with chronic musculosk...

Carfentanil - from an animal anesthetic to a deadly illicit drug.

Feb 15, 2021

The use of novel synthetic opioids as recreational drugs has become a public health concern as they are implicated in numerous fatal intoxications across the world. Synthetic opioids have played a maj...

Discharge Opioid Prescription Patterns after Kidney Cancer Surgery.

Feb 11, 2021

To describe opioid prescribing patterns for patients undergoing kidney cancer surgery and evaluate associations with medical resource utilization in the postoperative setting.Linked Surveillance, Epid...

Is Opioid-Free Post-Vasectomy Analgesia a Pain? A Single Surgeon Experience.

Feb 11, 2021

To determine the impact of transitioning from opioid to non-opioid analgesia post-vasectomy on unplanned opioid prescriptions and health encounters.A retrospective review for patients who underwent va...

The Effect of Preoperative Opioid Education on Opioid Consumption After Outpatient Orthopedic Surgery: A Prospective Randomized Trial.

Feb 11, 2021

Pain management and opioid consumption following outpatient orthopedic surgery may be influenced by several variables, including knowledge of safe opioid use. A prospective randomized study was undert...

Evaluation of Opioid Prescription and Consumption Habits Following Endovascular Aortic Aneurysm Repair.

Feb 08, 2021

There has been a dramatic rise in opioid-related deaths over the past decade. Most of the reduction strategies have focused on outpatient use; however, recent studies have demonstrated an association ...

Intraoperative Local Injection of Uterosacral Ligaments with Ropivacaine during Uterine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Feb 08, 2021

To perform a systematic review and meta-analysis of all randomized controlled trials that examined the efficacy of intraoperative local injection of the uterosacral ligaments with ropivacaine on posto...

Patterns of dispensed opioids after tonsillectomy in children and adolescents in South Carolina, United States, 2010-2017.

Feb 08, 2021

Tonsillectomy (with or without adenoidectomy) is a common pediatric surgical procedure requiring post-operative analgesia. Because of the respiratory depression effects of opioids, clinicians strive t...

Automated quantification of opioid withdrawal in neonatal rat pups using Ethovision® XT software.

Feb 04, 2021

Chronic prenatal exposure to opioids often causes fetal opioid dependence that leads to neonatal opioid withdrawal syndrome (NOWS) shortly after delivery. Rat models of NOWS often require quantifying ...

Tranexamic Acid Has No Effect on Post-operative Hemarthrosis or Pain Control Following ACL Reconstruction Using Bone Patella Tendon Bone Autograft: A Double-Blinded Randomized Control Trial.

Feb 04, 2021

The purpose of this double-blinded randomized controlled trial was to evaluate the use of intravenous (IV) tranexamic acid (TXA) in patients undergoing primary bone-patella tendon-bone (BTB) ACLR with...

A Clinical Trial of a Video Intervention Targeting Opioid Disposal After General Surgery: A Feasibility Study.

Feb 04, 2021

The opioid epidemic continues and although some initiatives have shown promise in reducing the number of opiates prescribed, few studies have focused on education of general surgery patients about hom...

Systematic Review and Meta-Analysis of the Association Between Non-Steroidal Anti-Inflammatory Drugs and Operative Bleeding in the Perioperative Period.

Feb 01, 2021

It is increasingly recognized that non-opioid analgesia important analgesia in the perioperative period. Specifically, NSAIDs (nonsteroidal anti-inflammatory drugs) have been touted as an adjunct or e...

Pain Management Strategies Following Anterior Cruciate Ligament Reconstruction - A Systematic Review with Network Meta-Analysis.

Feb 01, 2021

The purpose of this study is to systematically review the randomized controlled trials (RCTs) that evaluate various pain control interventions post-anterior cruciate ligament reconstruction (ACLR), in...

Association of opioid misuse with anxiety and depression: A systematic review of the literature.

Feb 01, 2021

The opioid epidemic is a public health problem associated with a host of negative outcomes. Although clinicians recognize covariation between opioid misuse with anxiety and depressive symptoms and dis...

Anxiety sensitivity and substance use: Differential levels across individuals primarily using opioids, cannabis, or stimulants.

Jan 28, 2021

The purpose of the current study was to compare levels of anxiety sensitivity (AS) across a treatment-seeking sample of individuals primarily using opioids, stimulants, or cannabis. Consistent with th...

Expanding access to methadone treatment in Ohio through federally qualified health centers and a chain pharmacy: A geospatial modeling analysis.

Jan 28, 2021

In the United States, methadone provision for opioid use disorder (OUD) occurs at opioid treatment programs (OTPs). Ohio recently enacted a policy to expand methadone administration to Federally Quali...

Isotonitazene: Fatal intoxication in three cases involving this unreported novel psychoactive substance in Switzerland.

Jan 28, 2021

The paper describes the first three deaths reported in Europe involved in isotonitazene consumption, a potent benzimidazole derivate opioid consumed in the recreational drug scene. Isotonitazene powde...

Legacy of the Plague

Sep 08, 2020

“Blessings for all you do.” “You Rock!” They arose from the grass on the median strip and stood there, beautifully askew in summer’s early morning mist; dozens of them. Created by loca...

Study Connects the Dots Between Smoking and Stroke Risk in African Americans

Jun 12, 2020

Risk increases as more cigarettes are smoked According to the Office of Minority Health of the Health and Human Services Administration, African Americans are 50% more likely to have a stroke than th...