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Addictions

How COVID-19 Has Impacted the Opioid Crisis

May 07, 2020

When it comes to rates of infection and addiction, both the coronavirus pandemic and the opioid epidemic disproportionately impact the poorest and most vulnerable members of society. As physicians, it...

Mental Disorders May Up Risk for Subsequent Medical Conditions

Apr 30, 2020

THURSDAY, April 30, 2020 (HealthDay News) -- The presence of a mental disorder is associated with an increased risk for many subsequent medical conditions, according to a study on a Danish population ...

Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca dependent manner.

Apr 28, 2020

Receptor-operated activation of TRPC4 cation channels requires G proteins and phospholipase-Cδ1 (PLCδ1) activation by intracellular Ca Concurrent stimulation of G pathway accelerates G activation of...

Opioid tapering after surgery: a qualitative study of patients' experiences.

Apr 28, 2020

Background and aims Patients usually receive a prescription for morphine or another opioid at discharge after surgery. Several studies have shown that many patients do not step down but develop persis...

Military veterans with and without post-traumatic stress disorder: results from a chronic pain management programme.

Apr 28, 2020

Background and aims There is very little published evaluation of the treatment of military veterans with chronic pain, with or without post-traumatic stress disorder. Few clinical services offer integ...

Evaluation of communication to general practitioners when opioid-naïve post-surgical patients are discharged from hospital on opioids.

Apr 28, 2020

To address the opioid crisis, much work has focused on minimizing opioid supply to surgical patients upon hospital discharge. Research is limited regarding handover to primary care providers. The aim ...

Kappa opioid receptors internalization is protective against oxygen-glucose deprivation through β-arrestin activation and Akt-mediated signaling pathway.

Apr 28, 2020

Hypoxia induces reversible κ-opioid receptor (KOR) internalization similar to the internalization that is induced by KOR agonists. In the current study, we demonstrate that this KOR internalization i...

Breast surgery and peripheral blocks. Is it worth it?

Apr 24, 2020

The objective of this review is to identify the potential of peripheral nerve blocks established over the last years for perioperative pain management in breast surgery. These new blocks will be discu...

Liposomal Bupivacaine Is Both Safe and Effective in Controlling Postoperative Pain After Spinal Surgery in Children: A Controlled Cohort Study.

Apr 24, 2020

Retrospective comparative cohort study.To evaluate: (1) pain relief efficacy; (2) opioid consumption; (3) length of stay (LOS); (4) discharge disposition (DD); and (5) safety and adverse effects of li...

Dedicated emergency department physical therapy is associated with reduced imaging, opioid administration, and length of stay: A prospective observational study.

Apr 24, 2020

Emergency department based Physical Therapy (ED-PT) has been practiced globally in various forms for over 20 years and is an emerging resource in the US. While there is a growing body of evidence sugg...

Sex Differences in Early Cognitive Development After Prenatal Exposure to Opioids.

Apr 24, 2020

Prenatal opioid exposure has been linked with impaired cognitive development, with boys potentially at elevated risk. In the present study, we examined cognitive and language development of children p...

Characteristics, symptom management and outcomes of 101 patients with COVID-19 referred for hospital palliative care.

Apr 24, 2020

Hospital palliative care is an essential part of the COVID-19 response but data are lacking. We identified symptom burden, management, response to treatment, and outcomes for a case series of 101 in-p...

Pharmacological and non-pharmacological treatments for neuropathic pain: Systematic review and French recommendations.

Apr 12, 2020

Neuropathic pain remains a significant unmet medical need. Several recommendations have recently been proposed concerning pharmacotherapy, neurostimulation techniques and interventional management, bu...

Prescription opioid overdose and adverse effect hospitalisations among injured workers in eight states (2010-2014).

Apr 12, 2020

High-risk opioid prescribing practices in workers' compensation (WC) settings are associated with excess opioid-related morbidity, longer work disability and higher costs. This study characterises the...

AcGly-Phe-Asn(OH) and AcGly-Phe-Asn(NH) tripeptides selectively affect the proliferation rate of MDA-MB 231 and HuDe cells.

Apr 12, 2020

There is increasing interest in the bioactivity of peptides carrying out antiproliferative, antihypertensive, antimicrobial, antioxidant, anticholesterolemic, opioid, and antidiabetic activities. The ...

Pharmacies and features of the built environment associated with opioid overdose: A geospatial comparison of rural and urban regions in Alabama, USA.

Apr 12, 2020

Elements of the physical environment have been shown to influence health behaviors including drug use and overdose mortality. Throughout the opioid epidemic in the United States, rural regions have be...

Problematizing the DSM-5 criteria for opioid use disorder: A qualitative analysis.

Apr 12, 2020

This paper includes the voices of people who are members of a peer-led drug user group (SNAP) in Canada who are receiving heroin-assisted treatment (HAT) outside of a clinical trial. Drawing from crit...

[Excitatory and aversive behaviors - electrophysiological observation of anterior cingulate cortex (ACC) in rats].

Apr 03, 2020

Increasing activities in anterior cingulate cortex (ACC) can enhance the aversion reactions associated with noxious stimuli. It has been known that opioid receptors activation can trigger endogenous a...

Nonfatal Drug Overdoses Treated in Emergency Departments - United States, 2016-2017.

Apr 03, 2020

In 2017, drug overdoses caused 70,237 deaths in the United States, a 9.6% rate increase from 2016 (1). Monitoring nonfatal drug overdoses treated in emergency departments (EDs) is also important to in...

Dexmedetomidine in Enhanced Recovery After Surgery (ERAS) Protocols for Postoperative Pain.

Apr 03, 2020

Effective acute pain management has evolved considerably in recent years and is a primary area of focus in attempts to defend against the opioid epidemic. Persistent postsurgical pain (PPP) has an inc...