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Addictions

Use of new psychoactive substances to mimic prescription drugs: the trend in France.

Apr 03, 2020

Among the expanding world of New Psychoactive Substances (NPS), Designer Medicines (DM) are designed to mimic psychoactive drugs and might lead to adverse events of various severity. The DM category i...

Antibody avidity-based approach to estimate population-level incidence of hepatitis C.

Apr 03, 2020

Accurate hepatitis C virus (HCV) incidence estimates are critical for monitoring progress towards HCV elimination goals, including an 80% reduction in HCV incidence by 2030. Moreover, incidence estima...

Nutritional implications of opioid use disorder: A guide for drug treatment providers.

Mar 24, 2020

The number of Americans seeking treatment for opioid use disorder (OUD) continues to increase. However, there are important nutritional implications of having OUD that often get overlooked by drug tre...

Self-Esteem and Non-Medical Use of Prescription Drugs among College Students: Coping as a Mediator.

Mar 24, 2020

Non-medical use of prescription drugs (NMUPD) has become a threat to public health. In the United States, NMUPD is especially common in young adults (aged 18-25). Self-esteem is a robust psychosocial...

Partnering with parents to improve outcomes for substance exposed newborns-a pilot program.

Mar 24, 2020

Assess impact of parental involvement in care provision for term substance exposed newborns (SENs).Prospective observational cohort study included mothers with opioid use disorder and their SENs over ...

On my own terms: Motivations for self-treating opioid-use disorder with non-prescribed buprenorphine.

Mar 24, 2020

The opioid overdose crisis in the United States has prompted an expansion of treatment services, including pharmacotherapy with buprenorphine. However, many people who use illicit opioids (PWUIO) self...

Pharmacological and molecular docking assessment of cryptotanshinone as natural-derived analgesic compound.

Mar 24, 2020

Medicinal plants from traditional chinese medicine are used increasingly worldwide for their benefits to health and quality of life for the relevant clinical symptoms related to pain. Among them, Salv...

Perianal block with ropivacaine as a supplement to anaesthesia in proctological surgery: double-blind randomized placebo-controlled trial (PERCEPT).

Mar 19, 2020

The benefit of a perianal block as an adjunct to general or regional anaesthesia is debated. This RCT aimed to compare pain at 24 h and up to 14 days after proctological surgery in patients with a...

Strong opioid consumption and its correlation with pain intensity and inpatient complexity. A six-year analysis in a tertiary hospital.

Mar 19, 2020

An increasing trend in opioid consumption has been observed worldwide in last decades. However, data related to opioid utilization in hospital settings is scarce. The aim of this study was to determin...

Predictors of long-term opioid effectiveness in chronic non-cancer pain patients attending multidisciplinary pain treatment clinics: A Quebec Pain Registry study.

Mar 19, 2020

This study aimed at identifying characteristics of individuals who are most likely to benefit from long-term opioid therapy in terms of reduction in pain severity and improved mental health-related qu...

Enduring consequences of perinatal fentanyl exposure in mice.

Mar 19, 2020

Opioid use by pregnant women is an understudied consequence associated with the opioid epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome (NOWS) and lifelong neurobe...

New Onset Depression and Anxiety After Spinal Fusion Surgery: Incidence and Risk Factors.

Mar 10, 2020

Retrospective database study.We sought to investigate trends and risk factors for new onset anxiety and/or depression within six months after elective spine surgery.Surgery represents a stressful expe...

Measuring Opioid Withdrawal in a Phase 3 Study of a New Analgesic, NKTR-181 (Oxycodegol), in Patients with Moderate to Severe Chronic Low Back Pain.

Mar 10, 2020

To evaluate the SUMMIT-07 trial opioid withdrawal results of NKTR-181 (oxycodegol), a new molecular entity mu-opioid receptor agonist.Phase 3, enriched-enrollment, double-blind, randomized-withdrawal ...

Risk of New Fractures in Vertebroplasty for Multiple Myeloma. A Retrospective Study.

Mar 10, 2020

Vertebroplasty is a percutaneous minimally invasive procedure indicated for vertebral collapse pain treatment. Among the known complications of the procedure is the augmented risk of new vertebral fra...

Full agonist opioid prescribing by primary care clinicians after buprenorphine training.

Mar 10, 2020

While primary care clinicians are being trained to use buprenorphine for the treatment of Opioid Use Disorder (OUD) in order to increase access to addiction treatment, it is not known what impact suc...

A Phylogenetic Analysis of HCV Transmission, Relapse, and Reinfection Among People Who Inject Drugs Receiving Opioid Agonist Therapy.

Mar 10, 2020

Understanding hepatitis C virus (HCV) transmission among people who inject drugs (PWID) is essential for HCV elimination. We aimed to differentiate reinfections from treatment failures and to identify...

Antinociceptive Effect of the Essential Oil of (female) Leaves on Adult Zebrafish ().

Feb 28, 2020

Raddi (Anacardiaceae) is popularly known in Brazil as and has pharmacological use as an astringent, antidiarrheal, anti-inflammatory, depurative, diuretic, and antifebrile agent. Although the neurop...

The Impact of Morphine Equivalent Daily Dose Threshold Guidelines on Prescribed Dose in a Workers' Compensation Population.

Feb 28, 2020

Prescription opioid overdose has increased markedly and is of great concern among injured workers receiving workers' compensation insurance. Given the association between high daily dose of prescripti...

Effects of transcutaneous electrical nerve stimulation on physical symptoms in advanced cancer patients receiving palliative care.

Feb 28, 2020

Transcutaneous electrical nerve stimulation (TENS) is primarily used for pain, but might be useful for various other physical symptoms, including nausea, fatigue, dyspnea, and constipation. However, f...

Chronic disease comorbidity in patients with oral leukoplakia: A matched case-control study.

Feb 28, 2020

The purpose of this study was to investigate the presence of chronic diseases in patients with oral leukoplakia (OL) compared to controls matched for age group, gender, smoking and alcohol use.This ca...