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Addictions

Using contributing causes of death improves prediction of opioid involvement in unclassified drug overdoses in US death records.

Feb 28, 2020

A substantial share of fatal drug overdoses is missing information on specific drug involvement, leading to under-reporting of opioid-related death rates and a misrepresentation of the extent of the o...

A Multi-Centered Case Series Highlighting the Clinical Use and Dosing of Lidocaine and Mexiletine for Refractory Cancer Pain.

Feb 25, 2020

Lidocaine infusion for pain control has been used for years. While some centers transition from continuous infusion lidocaine to oral mexiletine, there are no published studies to guide this conversio...

Law, Culture, and Fear: A Qualitative Study of Health Professionals' Perceptions of Narcotic Use Related to Cancer Pain.

Feb 25, 2020

Studies have shown barriers to appropriate narcotic use in the Middle East have negatively impacted patient outcomes. This study aimed to explore health professionals' perspectives regarding opioid us...

Prenatal Substance Use Disorders and Dental Caries in Children.

Feb 25, 2020

Substance use is common in women of reproductive age, but limited data exist on the dental health of their children, including risk of caries. We conducted a longitudinal cohort study of 790,758 infan...

Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives.

Feb 25, 2020

Morphine and its derivatives play inevitably important role in the μ-opioid receptor (MOR) targeted antinociception. A structure-activity relationship study is presented for novel and known orvinol a...

microRNA-422a Inhibits DCC Expression in a Manner Dependent on SNP rs12607853.

Feb 25, 2020

DCC netrin 1 receptor (DCC) affects the structure and function of the dopamine circuitry, which in turn affects the susceptibility to developing addiction. In a previous study, we found that single nu...

The impact of an enhanced recovery after minimally invasive surgery program on opioid use in gynecologic oncology patients undergoing hysterectomy.

Feb 17, 2020

To evaluate the effects of an enhanced recovery after minimally invasive surgery (MIS-ERAS) protocol on opioid requirements and post-operative pain in patients undergoing minimally invasive hysterecto...

Modeling Combination HCV Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the USA.

Feb 17, 2020

HCV treatment as prevention (TasP) strategies can contribute to HCV micro-elimination, yet complimentary interventions like opioid agonist therapies (OAT) and syringe services programs (SSP) may impro...

Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series.

Feb 17, 2020

It was suggested that D, L-Methadone might improve the clinical course of glioma patients. Owing to massive press coverage, patients demand the prescription of D, L-Methadone, but regarding its adjunc...

A randomised, double-blind, crossover, dose ranging study to determine the optimal dose of oral opioid to treat breakthrough pain for patients with advanced cancer already established on regular opioids.

Feb 17, 2020

Pain in people with advanced cancer is prevalent. When a stable dose of opioids is established, people still experience episodic breakthrough pain for which dosing of an immediate release opioid is us...

Associations between Neighborhood-Level Factors and Opioid-Related Mortality: A Multilevel Analysis using Death Certificate Data.

Feb 17, 2020

To identify associations between opioid-related mortality and neighborhood-level risk factors.Cross-sectional study.Massachusetts, USA.Using 2011-2014 Massachusetts death certificate data, we identifi...

Phosphates in medications: Impact on Dialysis Patients


Feb 13, 2020

Maintaining phosphorus balance in in-center hemodialysis (ICHD) patients is problematic despite recommended dietary restriction, dialysis, and phosphate binder use. Rarely is P content in prescribed m...

Neuroendocrine Effects of Naltrexone Versus Nalmefene

Feb 13, 2020

Naltrexone and nalmefene are approved for the treatment of alcohol use disorders, in different countries. Naltrexone is also approved for the treatment for opioid use disorders, most recently in a dep...

Estimating the impact of wide scale uptake of screening and medications for opioid use disorder in US prisons and jails.

Feb 13, 2020

Medications for opioid use disorder (OUD) are the most effective treatment for OUD, but uptake of these life-saving medications has been extremely limited in US prisons and jail settings, and limited ...

Trajectories of Retention in Opioid Agonist Therapy

Feb 13, 2020

Long-term engagement in opioid agonist therapy (OAT) has been consistently associated with reduced risk for morbidity and mortality in people with opioid use disorder (OUD). However, the dynamic natur...

Psychosocial Factors Associated with Sleep Quality and Duration Among Older Adults with Chronic Pain.

Feb 13, 2020

Sleep complaints are common among older adults with chronic pain. Because of the risk of significant side effects, sleep medications are not recommended as first-line treatments. Little is known about...

Opioid Crisis Along Mexico's Northern Border: Treatment Needs Mexican Opioid Crisis.

Feb 10, 2020

Heroin production for external markets and low rates of use in Mexico have had a long history. A recent shift toward an increase in use and related problems calls for the evaluation of treatment needs...

Opioid Prescribing Patterns of Oral and Maxillofacial Surgery Residents

Feb 10, 2020

The aim of this study was to report on the opioid prescribing patterns of oral and maxillofacial surgery residents for routine office-based procedures.A survey was sent to current resident members of ...

The impact of the abuse-deterrent reformulation of extended-release OxyContin on prescription pain reliever misuse and heroin initiation.

Feb 10, 2020

The introduction of abuse-deterrent OxyContin in 2010 was intended to reduce its misuse by making it more tamper resistant. However, some studies have suggested that this reformulation might have had ...

Nonpharmacological Adjunctive Treatment for Postpartum Women with Opioid Use Disorder

Feb 10, 2020

Over the past decade, opioid use disorder (OUD) among pregnant women has increased by over 400%. Although medication assisted treatment (MAT) provides necessary care for women with OUD, effective adju...