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ADHD/ADD

Melancholic features in major depression - A European multicenter study.

Feb 22, 2021

There is still a debate, if melancholic symptoms can be seen rather as a more severe subtype of major depressive disorder (MDD) or as a separate diagnostic entity. The present European multicenter stu...

Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis.

Feb 22, 2021

In multiple sclerosis (MS), monoaminergic systems are altered as a result of both inflammation-dependent reduced synthesis and direct structural damage. Aberrant monoaminergic neurotransmission is inc...

Comparative 12-month retention rate, effectiveness and tolerability of perampanel when used as a first add-on or a late add-on treatment in patients with focal epilepsies: The COM-PER study.

Feb 18, 2021

To compare the 12-month retention rate, effectiveness and tolerability of perampanel (PER) as a first or late add-on treatment in adult patients with focal-onset seizures (FOS), including focal to bil...

Experiences of Latino Participants Receiving Neutral Genomic Screening Results: A Qualitative Study.

Feb 18, 2021

The aim of the study was to characterize experiences of Latino participants receiving genomic screening results.Participants were recruited at a federally qualified health center in the USA. In-person...

Single- and Multimarker Genome-Wide Scans Evidence Novel Genetic Risk Modifiers for Venous Thromboembolism.

Feb 18, 2021

Previous genome-wide association studies (GWASs) have established several susceptibility genes for venous thromboembolism (VTE) and suggested many others. However, a large proportion of the genetic va...

Shared breastfeeding & other early multiple sclerosis risk factors: A case-control study.

Feb 15, 2021

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease. Etiology is thought to be multifactorial with genetic and environmental factors interplay. Our objective in this study is to evalu...

3D Virtual Planning For Rhinoplasty Using a Free Add-On For Open-Source Software.

Feb 15, 2021

Rhinoplasty is one of the most frequent aesthetic surgeries; the procedure can be challenging for inexperienced surgeons, and positive outcomes depend on good communication with the patient, proper pl...

Anthropometric indices and cardiometabolic risk factors in a Ghanaian adolescent population.

Feb 15, 2021

Adolescent overweight and obesity is a public health concern globally, especially in lower- and middle- income countries where there is an additional burden of undernutrition. The prevalence of adole...

Scaffolding the attention-deficit/hyperactivity disorder brain using transcranial direct current and random noise stimulation: A randomized controlled trial.

Feb 11, 2021

Improving symptomology and cognitive deficits in neurodevelopmental disorders is a crucial challenge. We examined whether neurostimulation protocols, which have been shown to yield long-term effects w...

Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption.

Feb 11, 2021

Tizanidine is an alpha2-adrenergic agonist, used to treat spasticity associated with multiple sclerosis and spinal injury. Tizanidine is primarily metabolized by CYP1A2 and is considered a sensitive i...

Assessing ADHD symptoms in clinical public practice: Is a reliable final diagnosis possible?

Feb 08, 2021

Attention deficit and hyperactivity disorder (ADHD) rates vary between 1% and 20% depending on the type of diagnosis guide used, the test used in the assessment, psychosocial factors, and professional...

ADHD severity as a predictor of cognitive task performance in children with Autism Spectrum Disorder (ASD).

Feb 08, 2021

In recent years, a number of studies have begun to explore the nature of Attention-Deficit/Hyperactivity Disorder (ADHD) in children with Autism Spectrum Disorder (ASD). In this study, we examined the...

Epidemic spreading in a weighted pig trade network.

Feb 08, 2021

The inclusion of edge weights can add valuable insights in the spreading processes within trade networks and may identify factors influencing the final epidemic size. The aim of the study was to evalu...

Early Clinical Results of the Tolerability, Safety, and Efficacy of Autologous Platelet-Rich Plasma Administration in Erectile Dysfunction.

Feb 04, 2021

Platelet-rich plasma (PRP) is useful in the treatment of different conditions and diseases as it contains concentrated levels of many growth factors.The aim of this study was to investigate the effect...

Treatment retention and abstinence of patients with substance use disorders according to addiction severity and psychiatry comorbidity: A six-month follow-up study in an outpatient unit.

Feb 04, 2021

The impact of psychiatric comorbidity and addiction features throughout the course of addiction has been widely studied. This is a naturalistic study conducted in an outpatient unit, where treatment f...

Relationship between physical and mental health comorbidities and COVID-19 positivity, hospitalization, and mortality.

Feb 04, 2021

Understanding the association between separate and combined mental and physical health diagnoses and COVID-19 outcomes is greatly needed to address the severity of illness.Data on 24,034 patients scre...

Cox-nnet v2.0: improved neural-network based survival prediction extended to large-scale EMR data.

Feb 01, 2021

Cox-nnet is a neural-network based prognosis prediction method, originally applied to genomics data. Here we propose the version 2 of Cox-nnet, with significant improvement on efficiency and interpret...

Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta-analysis.

Feb 01, 2021

Attention-deficit / hyperactivity disorder (ADHD) and Bipolar Disorder (BD) are common mental disorders with a high degree of comorbidity. However, no systematic review with meta-analysis has aimed to...

Hybrid governance and performances of environmental accounting.

Feb 01, 2021

Multiple centers of authority in hybrid forms create conditions of radical openness where questions of value and fitness are in flux. Environmental accounting is suggested as a condition for steadying...

Developmental vascular malformations in EPAS1-gain-of-function syndrome.

Jan 28, 2021

EPAS1, encoding HIF-2α, mutations were previously identified in a syndrome of multiple paragangliomas, somatostatinoma, and polycythemia. HIF-2α, when dimerized with HIF-1β, acts as an angiogenic t...