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ADHD/ADD

Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19.

Jan 28, 2021

We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care un...

First Report of Resistance to Ivermectin in Parascaris univalens in Iceland.

Jan 28, 2021

Horses in Iceland have been isolated for more than 1,000 yr but still harbor a similar range of gastrointestinal parasites as do horses across the world. The long isolation of the horses and their par...

Ethical Principles, Constraints and Opportunities in Clinical Proteomics.

Jan 18, 2021

Recent advances in mass spectrometry (MS)-based proteomics have vastly increased the quality and scope of biological information that can be derived from human samples. These advances have rendered cu...

Association between COMT methylation and response to treatment in children with ADHD.

Jan 18, 2021

COMT had been considered a promising candidate gene in pharmacogenetic studies in ADHD; yet the findings from these studies have been inconsistent. Part of these inconsistencies could be related to ep...

Does methylphenidate use affect sperm parameters in patients undergoing infertility investigation? A retrospective analysis of 9769 semen samples.

Jan 14, 2021

Methylphenidate (MPH) is the most widely prescribed therapy for attention deficit hyperactivity disorder. Animal studies have shown a potential adverse effect of MPH exposure on male fertility. We exa...

Sex-based differences after a single bout of exercise on PGC1α isoforms in skeletal muscle: A pilot study.

Jan 14, 2021

To date, there are limited and incomplete data on possible sex-based differences in fiber-types of skeletal muscle and their response to physical exercise. Adult healthy male and female mice completed...

Gabapentin add-on treatment for drug-resistant focal epilepsy.

Jan 14, 2021

This is an updated version of the Cochrane Review previously published in 2018. Epilepsy is a common neurological disorder characterised by recurrent seizures. Most people with epilepsy have a good pr...

Use of nintedanib in interstitial lung disease other than idiopathic pulmonary fibrosis: much caution is warranted.

Jan 04, 2021

Interstitial lung disease (ILD) other than idiopathic pulmonary fibrosis (IPF) is currently treated with immunosuppressive therapy, with a dynamic algorithm based on continued clinical surveillance. P...

Safinamide in neurological disorders and beyond: evidence from preclinical and clinical studies.

Jan 04, 2021

The discovery and development of safinamide, an alpha-aminoamide, has been a valuable addition to the existing clinical management of Parkinson's disease (PD). The journey of safinamide dates back to ...

Change in glucose-lowering medication regimen in individuals with type 2 diabetes mellitus during the COVID-19 pandemic in Germany.

Dec 17, 2020

Little is known on how the coronavirus disease-2019 (COVID-2019) has impacted the management of people with type 2 diabetes mellitus (T2DM). Therefore, the aim of this study was to estimate the propor...

PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API.

Dec 10, 2020

PANTHER (Protein Analysis Through Evolutionary Relationships, http://www.pantherdb.org) is a resource for the evolutionary and functional classification of protein-coding genes from all domains of lif...

Innovative Features and Functionalities of an Artificial Pancreas System: What Do Youth and Parents Want?

Dec 10, 2020

Participant-driven solutions may help youth and families better engage and maintain use of diabetes technologies. We explored innovative features and functionalities of an ideal artificial pancreas (A...

Parametric study on interply tracking in multilayer composites by analytic-signal technology.

Dec 10, 2020

The multilayer structure of fiber-reinforced polymers can be extracted by several ultrasonic techniques, each operating in a different frequency range. Generally, it is assumed that ultrasound at high...

Best practice for treating dyslipidaemia in patients with diabetes based on current international guidelines.

Dec 07, 2020

Dyslipidaemia is a major modifiable risk factor for atherosclerotic cardiovascular disease (ASCVD) in type 2 diabetes. We provide an in-context overview of recent trials of lipid-lowering pharmacother...

Prevalence of early-onset GDM and associated risk factors in a university hospital in Thailand.

Nov 26, 2020

This retrospective cohort study aimed to determine prevalence of GDM diagnosed before 24 weeks of gestation (early-onset GDM) and evaluate associated risk factors and compare pregnancy outcomes betw...

Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial.

Nov 26, 2020

This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hy...

Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients.

Nov 26, 2020

Acute graft-versus-host disease (aGVHD) is a leading cause of transplantation-related mortality after allogeneic hematopoietic stem cell transplantation (aHSCT). 16S ribosomal RNA (16S rRNA) gene-base...

Comparison of machine learning algorithms for the prediction of five-year survival in oral squamous cell carcinoma.

Nov 23, 2020

Machine learning analyses of cancer outcomes for oral cancer remain sparse compared to other types of cancer like breast or lung. The purpose of the present study was to compare the performance of mac...

Attention-deficit/hyperactivity disorder and oral health literacy exert an influence on the occurrence of dental caries in early adolescence.

Nov 23, 2020

Little is known regarding the influence of psychosocial factors on dental caries at early adolescence. The study aimed to investigate associations between family environment, attention-deficit/hyperac...

The haybiome: Characterising the viable bacterial community profile of four different hays for horses following different pre-feeding regimens.

Nov 19, 2020

Respirable dust in conserved forages can pose problems with equid respiratory health, thus soaking (W) and high temperature steaming (HTS) are employed to reduce the levels in hay. The aim of this stu...