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Bipolar Disorder

Peripheral Levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: a meta-analysis of mean differences and variability.

Aug 02, 2021

It is unclear whether differences exist in the magnitude and variability of pro-inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects with BD, as compared to healt...

[Gustav Nikolaus Specht (1860-1940) : His impact on Kraepelin's nosology and approaches to his position in National Socialism].

Jul 29, 2021

Gustav Specht (1860-1940) represents the beginning of the university psychiatry in Erlangen. 80 years after his death, this article focuses on Specht's role in the psychopathologic nosological discus...

Not in education, employment and training status in the early stages of bipolar I disorder with psychotic features.

Jul 29, 2021

There is a lack of existing research regarding young people with bipolar I disorder (BD-I) and psychotic features, who are not in education, employment, and training (NEET). Thus, the aims of the stud...

Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project.

Jul 29, 2021

Literature on older-age bipolar disorder (OABD) is limited. This first-ever analysis of the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) investigated associations am...

Evidence for the association between physiological and emotional states in adolescents and young adults without psychopathology under ecologically valid conditions.

Jul 26, 2021

Well-powered studies on the physiological concomitants underlying affect and its regulation during emerging adulthood are warranted to provide novel insight into mental health. The association between...

Cognitive Behavior Therapy for Depression From an Evolutionary Perspective.

Jul 26, 2021

Evolutionary medicine attempts to solve a problem with which traditional medicine has struggled historically; how do we distinguish between diseased states and "healthy" responses to disease states? F...

Behavioral mediators of stress-related mood symptoms in adolescence & young adulthood.

Jul 22, 2021

Stress is a risk factor for unipolar and bipolar mood disorders, but the mechanisms linking stress to specific symptoms remain elusive. Behavioral responses to stress, such as impulsivity and social w...

Assessment of Spaceflight Medical Conditions' and Treatments' Potential Impacts on Behavioral Health and Performance.

Jul 22, 2021

Long-duration space exploration missions will pose significant risks to the physical and behavioral health and performance of the crew. We documented the presence and frequency of (1) behavioral healt...

Lithium therapy and weight change in people with Bipolar Disorder: a systematic review and meta-analysis.

Jul 19, 2021

Lithium remains the gold standard maintenance treatment for Bipolar Disorder (BD). However, weight gain is a side effect of increasing relevance due to its metabolic implications. We conducted a syste...

Bipolar disorder and Susac syndrome: a case report.

Jul 19, 2021

Susac-syndrome is a rare autoimmune disease that manifests with mood alterations in up to 15% of cases and is usually treated with corticosteroids. We present the case of a 41-year-old woman with a fi...

Reliability, validity and psychometric properties of the Greek version of the Altman self rating mania scale.

Jul 19, 2021

Although self-rating mania scales have been developed, a lack of such instruments validated for the Greek population is noted. This study aims to examine the validity, reliability and psychometric pro...

Case Report: Clinical and Pharmacokinetic Profile of Lithium Monotherapy in Exclusive Breastfeeding. A Follow-Up Case Series.

Jul 15, 2021

Most guidelines advise that women taking lithium should not breastfeed. The variation in transfer is just one reason behind this advice. To present clinical and pharmacokinetic data of nine mother-i...

Efficacy of Cognitive Behavioural Therapy for Bipolar Disorder: a Systematic Review.

Jul 12, 2021

Bipolar disorder (BD) is a serious mental illness with a chronic course and significant morbidity and mortality. BD has a lifetime prevalence rate of 1% to 1.5% and is characterised by recurrent episo...

Socio-demographic and clinical characteristics of patients admitted at the Lunatic Asylum, Bengaluru (now NIMHANS) and treatment outcome in the early 20th century (1903-1911).

Jul 12, 2021

Historiography of South Asian mental asylums is generally skewed towards asylums operated by the British. The Lunatic asylum, Bengaluru, later to become NIMHANS, was one of the early asylums and was a...

Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders.

Jul 08, 2021

Increasing evidence indicates lithium (Li) efficacy in neuropsychiatry, pointing to overlapping mechanisms that occur within distinct neuronal populations. In fact, the same pathway depending on which...

Enlightened: addressing circadian and seasonal changes in photoperiod in animal models of bipolar disorder.

Jul 08, 2021

Bipolar disorders (BDs) exhibit high heritability and symptoms typically first occur during late adolescence or early adulthood. Affected individuals may experience alternating bouts of mania/hypomani...

Fish Oil Supplementation Alters Emotion-Generated Corticolimbic Functional Connectivity in Depressed Adolescents at High-Risk for Bipolar I Disorder: A 12-Week Placebo-Controlled fMRI Trial.

Jul 05, 2021

To evaluate the effects of fish oil (FO), a source of the omega-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on emotion-generated corticolimbic ...

Efficacy of Endoxifen, a Protein kinase C inhibitor for acute and mixed mania: Some concerns worth considering.

Jul 05, 2021

We read the article by Ahmad et al with great interest. The study concluded that endoxifen is efficacious and safe in patients with acute manic episodes with/without mixed features. However, we are wo...

Early detection of bipolar disorders and treatment recommendations for help-seeking adolescents and young adults: Findings of the Early Detection and Intervention Center Dresden.

Jul 05, 2021

Early identification and intervention of individuals with risk factors for or subtle prodromal symptoms of bipolar disorders (BD) may improve the illness course and prevent adverse long-term consequen...

'Pediatric Bipolar Disorder' rates are still lower than claimed: a re-examination of eight epidemiological surveys used by an updated meta-analysis.

Jul 01, 2021

'Pediatric bipolar disorder' (PBD) is a controversial diagnosis with varying rates of clinical diagnosis. A highly cited meta-analysis (Van Meter et al. 2011) of a dozen epidemiological surveys sugges...