Median hazard ratio was 1.37 for link between mental disorder, medical condition in Danish cohortRead More
Alzheimer’s disease (AD) is a progressive brain disorder characterized by memory loss and the accumulation of two insoluble protein aggregates, tau neurofibrillary tangles and beta-amyloid plaques. Widespread mitochondrial...Read More
Subthalamic Deep Brain Stimulation modulates proprioceptive integration in Parkinson’s Disease during a postural task.
Defective proprioceptive integration may play a role in the pathophysiology of motor symptoms in Parkinson’s disease (PD). Dysfunction related to proprioceptively-evoked postural reactions in PD patients is still a...Read More
Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports.
Several lines of evidence from neuropathological studies, human genetics, in vitro aggregation studies and cellular and animal models support the hypothesis that aSyn plays a central role in the formation of Lewy pathologies....Read More
Does perceived control mediate the relationship between stigma and well-being for individuals with Parkinson’s disease?
Stigma is a known correlate of well-being for many neurological conditions. Perceived control is also an important variable in models of adaptation to living with a health condition. The purpose of this study was to investigate...Read More
Previous reports proposed prelemniscal radiations (Raprl) as a target to treat motor symptoms of Parkinson’s disease, and this was found particularly effective to control rest and postural tremor. However, tremor of other...Read More
First radiolabeling of a ganglioside with a positron emitting radionuclide – in vivo PET demonstrates low exposure of radiofluorinated GM1 in non-human primate brain.
Gangliosides are biologically important glycolipids widely distributed in vertebrate cells. An important member of the ganglioside family is the monosialylganglioside GM1, which has been suggested as a potential therapeutic for...Read More
Nonlinear and mixed inhibitory effect of matrine on the cytotoxicity of oligomeric amyloid-β protein.
The formation of amyloid β-protein (1-42) (Aβ42) oligomers and Aβ42 oligomer cytotoxicity are two defining characteristics of the etiology of Alzheimer’s disease (AD). In this study, we found that matrine (Mat) could...Read More
Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer’s disease.
Alzheimer’s disease (AD) is a complex neurodegenerative disease with multiple pathological features. Multifunctional compounds able to simultaneously interact with several pathological components have been considered as a...Read More