Whether LCZ696 (neprilysin inhibitor + valsartan) has greater advantages of blood pressure (BP) lowering than angiotensin II type 1 receptor blockers (ARBs) is unclear. To provide more detailed information about the benefits of...
This study tested the hypothesis that analyzing longitudinal item scores of the Unified Parkinson’s Disease Rating Scale could allow a smaller trial size and describe a drug’s effect on symptom progression. Two...
“Psoriasis has been linked with a variety of systemic disorders, including cardiovascular (CV)...
Accumulation of senile plaques mainly composed of neurotoxic amyloid-beta peptide (Aβ) is a pathological hallmark of Alzheimer’s disease (AD). Sestrin2 inducible by various types of stressors is known to promote autophagy...
Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery.To assess whether the use of the advanced functions of a patient’s programmer...
Analyzing the progression of Alzheimer’s disease (AD) is challenging due to lacking sensitivity in currently available measures. AD stages are typically defined based on cognitive cut-offs, but this results in...
Current medicine for Alzheimer’s disease (AD) cannot effectively reverse or block nerve injury. Traditional Chinese Medicine practice and research imply (Fuzi) may meet this goal.Analysing the anti-AD effect of Fuzi and...
Neuroinflammation plays a key role in PD pathogenesis, and allogeneic bone marrow-derived mesenchymal stem cells can be used as an immunomodulatory therapy.The objective of this study was to prove the safety and tolerability of...
Nucleotide sugars are required for the synthesis of glycoproteins and glycolipids, which play crucial roles in many cellular functions such as cell communication and immune responses. Uridine diphosphate-glucose (UDP-Glc) was...
Sphingolipids (SLs) are bioactive lipids involved in various important physiological functions. The SL pathway has been shown to be affected in several brain-related disorders, including Alzheimer’s disease (AD). Recent...
Here, we examine the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein (αSYN) species in astrocytes derived from induced pluripotent stem cells. Human astrocytes treated with TNF-α...
Language impairment in Parkinson’s disease (PD) has been investigated at different levels of linguistic skills. Only a few studies dealt with pragmatic abilities in PD, and these suggest an impairment of pragmatic skills,...
