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Dementia

#VisualAbstract: Increased Physical Activity Is a Long-Term Protective Factor for Dementia

May 20, 2022

1. Physical activity was significantly associated with a decreased incidence of all-cause dementia and Alzheimer’s disease, irrespective of follow-up length, baseline age and study quality. 2...

Heart Failure Outcomes After Discharge to SNFs With Delirium

Apr 12, 2022

Patients with HF who developed delirium were more likely to die within 30 days post-hospitalization and within a year post-hospitalization. Dementia and delirium are highly prevalent conditions...

Adverse Childhood Experiences Linked With Dementia Risk in Older Adults

Feb 02, 2022

Adverse childhood experiences (ACEs) are associated with a greater risk for many common conditions that contribute to mortality in adulthood, but limited evidence examines whether ACEs correlate with ...

White matter changes in drug-naïve Parkinson's disease patients with impulse control & probable REM sleep behavior disorders.

Oct 25, 2021

According to epidemiological studies, Parkinson's disease (PD) patients with probable REM sleep behavior disorder (pRBD) are more prone to develop impulse control disorders (ICDs), which is shown to b...

LncRNA NEAT1 knockdown ameliorates MPP-induced cell injury through miR-519a-3p/SP1 axis in Parkinson's disease.

Sep 13, 2021

Parkinson's disease (PD) is a neurodegenerative disease and is characterized by resting tremor, dementia, and gait disorder. Previous studies have indicated that long noncoding RNA (lncRNA) participat...

Disability and life satisfaction in neurological disorders: The role of depression and perceived cognitive difficulties.

Sep 13, 2021

This study assessed factors associated with disability and life satisfaction in a large cohort of 2246 Australian adults with neurological disorders who completed an online survey of mental health and...

Fasting state is one of the factors associated with plasma levodopa fluctuations during levodopa‒carbidopa intestinal gel treatment.

Sep 13, 2021

Some patients with Parkinson's disease (PD) undergoing levodopa‒carbidopa intestinal gel (LCIG) treatment experience motor fluctuations in the afternoon. The migrating motor complex, a specific peri...

Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8-years follow-up.

Aug 19, 2021

Carriers of the G2019S mutation of LRRK2 provide a great opportunity to investigate the premotor stages of PD. We have studied by serial clinical and DaT-SPECT evaluations a cohort of asymptomatic car...

Icariin Ameliorate Alzheimer's Disease by Influencing SIRT1 and Inhibiting Aβ cascade Pathogenesis.

Aug 19, 2021

Of all types of dementia, Alzheimer's disease is the type that has the highest proportion of cases and is the cause of substantial medical and economic burden. The mechanism of Alzheimer's disease is ...

Exposure of Environmental Contaminants and Development of Neurological Disorders.

Aug 05, 2021

In this era of technology, neurological disorders are the most prevalent disorders in growing population. Alzheimer's and Parkinson's diseases are the most common neurological disorders which are mani...

Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: a Methodological Workflow.

Aug 05, 2021

Studies of the metal content of metalloproteins in tissues from the human central nervous system (CNS) can be compromised by preparative techniques which alter levels of, or interactions between, meta...

Olfaction, cholinergic basal forebrain degeneration, and cognition in early Parkinson disease.

Aug 05, 2021

Impaired olfaction and reduced cholinergic nucleus 4 (Ch4) volume both predict greater cognitive decline in Parkinson's disease (PD). We examined the relationship between olfaction, longitudinal chang...

Parkinson's disease patients may have higher rates of Covid-19 mortality in Iran.

Jul 15, 2021

Parkinson's disease (PD) patients may be at increased risk of Covid-19 mortality due to the nature of their disease or underlying conditions.The information of 12,909 Covid-19 patients who were hospit...

Using complexity-entropy planes to detect Parkinson's disease from short segments of haemodynamic signals.

Jul 15, 2021

There is emerging evidence that analysing the entropy and complexity of biomedical signals can detect underlying changes in physiology which may be reflective of disease pathology. This approach can b...

Exercise-Mediated Alteration of miR-192-5p Is Associated with Cognitive Improvement in Alzheimer's Disease.

Jul 15, 2021

Physical exercise is an important component of managing Alzheimer's disease (AD). miRNAs can be modulated by exercise intervention.The study explored the involvement and potential mechanism of miR-192...

#PWChat Recap: The Complexities of Dementia Care

Jul 12, 2021

The latest installment of the #PWChat series centered around trends in continuing medical education. Below are the highlights from the chat. You can read the full transcript here, by scrolling th...

Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.

Jun 24, 2021

Fibril formation and aggregation of α-synuclein are important for the pathogenesis of neurodegenerative disorders including Parkinson's disease. In familial Parkinson's disease, the G51D mutation of ...

Mitochondrial dysfunction in Alzheimer's disease: therapeutic implications of lithium.

Jun 24, 2021

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of abnormal tau proteins within neurons and amyloid plaques in the brain parenchyma,...

Intrusion Errors and Progression of Cognitive Deficits in Older Adults with Mild Cognitive Impairment and PreMCI States.

Jun 24, 2021

Among persons with amnestic mild cognitive impairment (aMCI), intrusion errors on subscales that measure proactive semantic interference (PSI) may be among the earliest behavioral markers of elevated ...

Acquisition and processing of high-speed atomic force microscopy videos for single amyloid aggregate observation.

Jun 10, 2021

The structural dynamics of the amyloid protein aggregation process are associated with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. High-speed atomic force micros...