The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson’s disease. Copper promotes α-synuclein aggregation and toxicity in vitro. The level of copper and copper transporter 1, which is the...
Chronic stress and high levels of glucocorticoids produce functional and structural changes in brain and especially in the hippocampus, an important limbic system structure that plays a key role in cognitive functions including...
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive decline of memory and cognitive function. The disease is characterized by the presence of amyloid plaques, tau tangles, altered...
To determine whether vascular parkinsonism (VaP) patients with visually normal dopamine transporter (DAT) scans have presynaptic dopaminergic depletion.We enrolled 23 VaP patients who had parkinsonism, relevant diffuse...
Parkinson’s disease (PD) is associated with an action language deficit. Subthalamic nucleus deep brain stimulation (STN DBS) deteriorates verbal fluency, but may improve verb naming more than nouns in PD. We investigated...
Depression is considered a psychological risk factor for Alzheimer’s disease (AD). We sought to examine the differential associations of depression severity with cognitive decline, clinical progression to mild cognitive...
The Subthalamic Nucleus (STN) is the most selected target for the placement of the Deep Brain Stimulation (DBS) electrode to treat Parkinson’s disease. Its identification is a delicate and challenging task which is based...
Brain functional connectivity (FC) analyses based on magneto/electroencephalography (M/EEG) signals have yet to exploit the intrinsic high-dimensional information. Typically, these analyses are constrained to regions of interest...
Neuroprotection targeting mitochondrial dysfunction has been proposed as a potential therapeutic strategy for Parkinson’s disease (PD). Ursodeoxycholic acid (UDCA) has been shown to prevent neuronal damage; however, the...
The aberrant accumulation of disease-specific protein aggregates accompanying cognitive decline is a pathological hallmark of age-associated neurological disorders, also termed as proteinopathies, including Alzheimer’s...
Dysfunction of cholinergic system plays an important role in disease associated with cognitive blockage, such as Alzheimer’s disease (AD). Central administration of scopolamine, an antagonist of acetylcholine receptor,...
Parkinson’s disease (PD) is diagnosed when motor symptoms emerges, which almost 70% of dopamine neurons are lost. Therefore, early diagnosis of PD is crucial to prevent the progress of disease. Blood-based biomarkers,...
