Vets With Pain-PTSD Comorbidity Showed Worse Outcomes Than Those With Pain Alone
“There are important reasons to study chronic pain and PTSD together,” says Matthew J. Bair, MD,...
Psychiatry General
Suicidality and Aggression During Antidepressant Treatment
Antidepressant treatment trugs include selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). The incidences of SSRI-induced suicides date back to the 1990s, but the exact...
Benzodiazepine Use and Risk of Dementia or Cognitive Decline
Benzodiazepines are a class of drugs commonly used to treat insomnia and anxiety. But long-term use of benzodiazepines has been associated with several risk factors. This study aims to investigate the risk of incident dementia...
Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites.
Structural brain alterations have been repeatedly reported in schizophrenia; however, the pathophysiology of its alterations remains unclear. Multivariate pattern recognition analysis such as support vector machines can classify...
Nutritional and therapeutic approaches for protecting human gut microbiota from psychotropic treatments.
Emerging evidence highlighted the essential role played by the microbiota-gut-brain axis in maintaining human homeostasis, including nutrition, immunity, and metabolism. Much recent work has linked the gut microbiota to many...
Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson’s disease.
The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson’s disease. Copper promotes α-synuclein aggregation and toxicity in vitro. The level of copper and copper transporter 1, which is the...
Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron.
Chronic stress and high levels of glucocorticoids produce functional and structural changes in brain and especially in the hippocampus, an important limbic system structure that plays a key role in cognitive functions including...
Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer’s disease.
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive decline of memory and cognitive function. The disease is characterized by the presence of amyloid plaques, tau tangles, altered...
Psychological factors in personal and clinical recovery in bipolar disorder.
Research into bipolar disorder (BD) has primarily focused upon clinical recovery (CR), i.e. symptom reduction, and overlooked personally meaningful recovery outcomes emphasized by service users. Personal recovery (PR) has been a...
Metabolomic analysis to detect urinary molecular changes associated with bipolar depression.
Bipolar disorder (BD) is a debilitating mental disorder with complex clinical manifestations and low diagnostic accuracy. Depressive episodes are most common in the course of BD with high comorbidity and suicide rates, which...
Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.
Synaptotagmin-7 (Syt7) probably plays an important role in bipolar-like behavioral abnormalities in mice; however, the underlying mechanisms for this have remained elusive. Unlike antidepressants that cause mood overcorrection...
Prevalence of early-onset GDM and associated risk factors in a university hospital in Thailand.
This retrospective cohort study aimed to determine prevalence of GDM diagnosed before 24 weeks of gestation (early-onset GDM) and evaluate associated risk factors and compare pregnancy outcomes between different GDM status. A...
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