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Psychiatry General

Partnering with parents to improve outcomes for substance exposed newborns-a pilot program.

Mar 24, 2020

Assess impact of parental involvement in care provision for term substance exposed newborns (SENs).Prospective observational cohort study included mothers with opioid use disorder and their SENs over ...

On my own terms: Motivations for self-treating opioid-use disorder with non-prescribed buprenorphine.

Mar 24, 2020

The opioid overdose crisis in the United States has prompted an expansion of treatment services, including pharmacotherapy with buprenorphine. However, many people who use illicit opioids (PWUIO) self...

Pharmacological and molecular docking assessment of cryptotanshinone as natural-derived analgesic compound.

Mar 24, 2020

Medicinal plants from traditional chinese medicine are used increasingly worldwide for their benefits to health and quality of life for the relevant clinical symptoms related to pain. Among them, Salv...

Pathological laughing and psychotic disorder: the medical evaluation of the Joker.

Mar 20, 2020

In the psychological thriller film Joker, released in 2019 and starring Joaquin Phoenix in the first role, another possible origin story for this iconic character is reported. Above all, it brings ...

[Performance of sleep questionnaires for the diagnosis of obstructive sleep apnea syndrome].

Mar 19, 2020

Background The diagnosis of obstructive sleep apnea syndrome (OSAS) is based on nocturnal records: polysomnography or respiratory polygraphy. However, their high costs limit their use. Aim To examine ...

[Gender differences in clinical features and performance of sleep questionnaires in adults with obstructive sleep apnea syndrome].

Mar 19, 2020

Women with obstructive sleep apnea-hypopnea syndrome (OSAS) are less likely to be assessed or to receive an appropriate diagnosis, and they may have poorer quality of life and survival rates.To assess...

Irritability Disorders in Adults: Diagnostic Categories Missing in Plain Sight?

Mar 19, 2020

Research into irritability has focused largely on its developmental and child-adolescent manifestations. Although irritability appears to be as elemental an experience as anxiety or depression, diagno...

Respiratory safety of lemborexant in healthy adult and elderly subjects with mild obstructive sleep apnea: A randomized, double-blind, placebo-controlled, crossover study.

Mar 19, 2020

Lemborexant is a dual orexin receptor antagonist indicated for the treatment of adult and elderly individuals with insomnia. Some current pharmacologic treatments for insomnia cause respiratory depres...

Predictors of Frequent Emergency Department Utilization for Mental Health Reasons.

Mar 19, 2020

Overcrowding in emergency departments (ED) jeopardizes quality and access to health care, which represents a major issue for service delivery. This study determined predictors of frequent ED utilizati...

The prevalence and comorbidity rates of specific learning disorder among primary school children in Turkey.

Mar 19, 2020

The aim of the present study was to explore the prevalence of specific learning disorder (SLD), comorbid disorders, and risk factors in primary school children for the first time in two-stage design ...

The complex link between schizophrenia and dementia: Targeting Ca2+/cAMP signalling.

Mar 19, 2020

Considering a consistent body of evidence has been showing that schizophrenia patients have had an increased risk of developing dementia, the hypothesis that dementia and schizophrenia share a complex...

An Extended Swedish National Adoption Study of Bipolar Disorder Illness and Cross-Generational Familial Association With Schizophrenia and Major Depression.

Mar 19, 2020

Information about how risk for bipolar disorder is transmitted across generations and how parental risk for bipolar disorder relates to their children's risk for schizophrenia and major depression is ...

Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia.

Mar 19, 2020

Three-dimensional cerebral organoids generated from patient-derived induced pluripotent stem cells (iPSCs) may be used to interrogate cellular-molecular underpinnings of schizophrenia.To determine tra...

Physicians' and Attorneys' Beliefs and Attitudes Related to the Brain Disease Model of Addiction.

Mar 19, 2020

Addiction is increasingly considered a chronic, relapsing brain disease; however, many scholars still disagree with the brain disease model of addiction. We set out to provide evidence of attorneys' a...

The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration.

Mar 19, 2020

Vulnerability to drug addiction relies on substantial individual differences. We previously demonstrated that serotonin transporter knockout (SERT ) rats show increased cocaine intake and develop sign...

Distortion-Free Sensing of Neural Activity Using Graphene Transistors.

Mar 19, 2020

Graphene solution-gated field-effect transistors (g-SGFETs) are promising sensing devices to transduce electrochemical potential signals in an electrolyte bath. However, distortion mechanisms in g-SGF...

Effectiveness of Cannabinoids for Treatment of Dementia: A Systematic Review of Randomized Controlled Trials.

Mar 19, 2020

: In the last decade, research has focused on developing novel medications for the treatment of dementia. Cannabinoids are one of the potential agents under investigation. The present study aimed to e...

β‑asarone modulates Beclin‑1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APP/PS1 transgenic mice with Alzheimer's disease.

Mar 19, 2020

Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly population. Autophagy is a well‑known regulator of neurodegenerative diseases and β‑asarone has been discovered to ha...

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.

Mar 19, 2020

Alzheimer's disease is the world's most common neurodegenerative disorder. It is associated with neuroinflammation involving activation of microglia by β-amyloid (Aβ) deposits. Based on previous stu...

Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis.

Mar 19, 2020

Identifying the interplay between socioeconomic markers (education and financial resources) and polygenetic predisposition influencing the time of dementia and the diagnosis of clinical Alzheimer's di...

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