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The Type Toxin-Antitoxin System in IncC Plasmids Is a Mobilizable Ciprofloxacin-Inducible System.

Jun 03, 2021

A putative type II toxin-antitoxin (TA) module almost exclusively associated with conjugative IncC plasmids is homologous to the family of TA systems found in chromosomes and plasmids of several spec...

Blockade of orexin receptors in the hippocampal dentate gyrus reduced the extinction latency of morphine-induced place preference in male rats.

May 13, 2021

Relapse to drugs such as opioids is a major challenge in addiction therapy. It has been known that the orexinergic system has a significant role in mediating reward processing and addiction, as shown ...

Effects of addiction science on conceived freewill and responsibility.

May 10, 2021

Although there is speculation that medicalization of addiction undermines conceived agency, only relatively modest effects have been reported. Research participants generally have ideas about addictio...

Assessing Drug Overdose Risk Among People With HIV

May 06, 2021

Preventable deaths, including those due to drug overdose (OD), are a significant public health concern in New York City (NYC), with rates increasing during the past decade, according to Sarah L. Braun...

Viewing personalized video clips recommended by TikTok activates default mode network and ventral tegmental area.

May 06, 2021

Cutting-edge recommendation algorithms have been widely used by media platforms to suggest users with personalized content. While such user-specific recommendations may satisfy users' needs to obtain ...

Cannabidiol prevents amphetamine relapse and modulates D1- and D2-receptor levels in mesocorticolimbic brain areas of rats.

May 06, 2021

Amphetamine (AMPH) is an addictive psychostimulant highly used worldwide and its consumption is related to neurotoxic effects. Currently, there is no pharmacotherapy approved for treating AMPH or othe...

Are Individuals with Substance Use Disorders at Higher Risk of SARS-CoV-2 Infection? Population-Based Registry Study in Northern Italy.

May 06, 2021

This study assesses whether individuals with substance use disorder are at greater risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than people in the general population....

The negative impact of smartphone usage on nursing students: An integrative literature review.

Apr 26, 2021

Smartphones are ubiquitous, and for some, an indispensable companion. In nursing education curricula and clinical healthcare settings, smartphones have the potential to augment student learning. Nursi...

Potentiation of (α4)2(β2)3, but not (α4)3(β2)2, Nicotinic Acetylcholine Receptors Reduces Nicotine Self-Administration and Withdrawal Symptoms.

Apr 22, 2021

The low sensitivity (α4)3(β2)2 (LS) and high sensitivity (α4)2(β2)3 (HS) nAChR isoforms may contribute to a variety of brain functions, pathophysiological processes, and pharmacological effects as...

Sexual incentive delay in the scanner: Sexual cue and reward processing, and links to problematic porn consumption and sexual motivation.

Apr 08, 2021

The use of pornography, while unproblematic for the majority, can grow into addiction-like behavior which in its extreme form is labeled as compulsive sexual behavioral disorder in the ICD-11 (WHO, 20...

Theoretical conceptualisations of problematic exercise in psychometric assessment instruments: A systematic review.

Apr 08, 2021

The aim of the present systematic review was to identify psychometric tools developed to assess problematic exercise in order to identify and compare their theoretical conceptualisations on which they...

Predictors of weight loss in participants with obesity following bariatric surgery - A prospective longitudinal fMRI study.

Apr 05, 2021

Prevalence rates of overweight and obesity are increasing worldwide and are amongst the leading causes of death. Participants with obesity also suffer from poorer mental health with a concomitant redu...

Appropriateness of the post-operative rehabilitation of low energy hip fractures in elderly in comparison with the AAOS appropriate use criteria at a level one trauma center.

Apr 01, 2021

This study aimed to assess the appropriateness of the post-operative rehabilitation of low energy hip fractures in the elderly by comparing between the rehabilitations actually provided at level one t...

A systematic review of metacognitions in Internet Gaming Disorder and problematic Internet, smartphone, and social networking sites use.

Apr 01, 2021

The use of new technologies is growing, and some authors have suggested that frequent use might hide a non-chemical addiction (i.e., technological addiction). Over the last five years several studies ...

Associations between Reason for Inpatient Palliative Care Consultation, Timing, and Cost Savings.

Mar 25, 2021

Specialty palliative care (SPC) provides patient-centered care to people with serious illness and may reduce costs. Specific cost-saving functions of SPC remain unclear. (1) To assess the effect of ...

Assessing Prescription Opioid Medical Use & Misuse in Parents & Offspring

Mar 22, 2021

According to recent data, nearly 50% of adolescents who misuse prescription opioids report obtaining the drugs from relatives or friends. Understanding the parental origins of adolescent prescription ...

A thematic analysis of the perceptions of a community-based exercise program on the health and well-being of ageing adults.

Mar 18, 2021

This study explores a weekly community-based exercise program (CBEP) for ageing adults in Gippsland, Victoria, Australia. This program aims to improve the health and well-being of ageing adults and wa...

Problematic usage of the internet and eating disorder and related psychopathology: a multifaceted, systematic review and meta-analysis.

Mar 15, 2021

Eating disorders are widespread illnesses with significant impact. There is growing concern about how those at risk of eating disorders overuse online resources to their detriment. We conducted a pre-...

Internet Addiction and Maladaptive Schemas: The Potential Role of Disconnection/Rejection and Impaired Autonomy/Achievement.

Mar 11, 2021

Problematic internet use (PIU) has become public health concern, particularly among adolescents and emerging adults. There is growing interest concerning the potential impacts of early maladaptive sch...

Methamphetamine-related postmortem cases in Jeddah, Saudi Arabia.

Mar 08, 2021

A more than 500% increase in the number of deaths involving methamphetamine occurred between 2016 and 2018 in Jeddah, Saudi Arabia. As such, this report employed a validated liquid chromatography tand...