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Opioids

Safety of Erector Spinae Plane Blocks in Patients With Chest Wall Trauma on VTE Prophylaxis.

Mar 04, 2021

Current guidelines for severe rib fractures recommend neuraxial blockade in addition to multimodal pain therapies. While the guidelines for venous thromboembolism prevention recommend chemoprophylaxis...

Problematic internet use: The effect of comorbid psychopathology on treatment outcomes.

Mar 01, 2021

Problematic Internet use (PIU) behaviours involve one's maladaptive Internet use and have been often described as secondary manifestations of pre-existing psychopathology. Furthermore, different profi...

Hand therapists' perspectives and practices related to musculoskeletal pain: A biopsychosocial lens.

Mar 01, 2021

While the biopsychosocial model is advocated for pain management, biomedical approaches continue to dominate in practice. Understanding musculoskeletal clinicians' perspectives and practices related t...

Comparison of psychological symptoms and cognitive functions in patients under maintenance treatment with methadone or buprenorphine, current opioid users and healthy subjects.

Feb 25, 2021

Methadone and buprenorphine can affect the psychological symptoms and cognitive functioning of substance users. This study aimed to compare psychological symptoms and neuropsychological functioning in...

Cortical thickness and subcortical volume abnormalities in male crack-cocaine users.

Feb 25, 2021

Crack-cocaine offers a higher risk of abuse than intranasal and intravenous use of cocaine. Yet, current treatments remain disappointing and our understanding of the mechanism of crack-cocaine neuroto...

Opioid Mortality Following Implementation of Medical Cannabis Programs in the United States.

Feb 25, 2021

The United States is in the midst of an opioid overdose epidemic. Emerging evidence suggests that medical cannabis (MC) may reduce use of opioids for pain in some individuals, with potential impacts o...

High-fat feeding causes inflammation and insulin resistance in the ventral tegmental area in mice.

Feb 22, 2021

The reward system plays an important role in the pathogenesis of not only drug addiction, but also diet-induced obesity. Recent studies have shown that insulin and leptin receptor signaling in the ven...

Adverse childhood experiences and problematic smartphone use among college students: Findings from a pilot study.

Feb 22, 2021

There has been a tremendous increase in the use of smartphones among college students and alongside the benefits there is growing concern over problematic/addictive smartphone use (PSU). Among the mos...

Evaluation of an emergency department-based opioid overdose survivor intervention: Difference-in-difference analysis of electronic health record data to assess key outcomes.

Feb 22, 2021

In recent years, a number of emergency department (ED)-based interventions have been developed to provide supports and/or treatment linkage for people who use opioids. However, there is limited resear...

Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: the possible role of μ-opioid receptors and ΔFosB in the brain reward pathway.

Feb 18, 2021

Prenatal opioids exposure negatively affects the neurobehavioral abilities of children born from dependence dams. Adolescent housing conditions can buffer the detrimental impacts of early life experie...

Intermittent REM sleep deprivation attenuates the development of morphine tolerance and dependence in male rats.

Feb 18, 2021

Opioid agonists are used in clinic for pain management, however this application is challenged by development of tolerance and dependence following prolonged exposure. Various approaches have been sug...

Depressive symptoms and depression in individuals with internet gaming disorder: A systematic review and meta-analysis.

Feb 18, 2021

Although depression has frequently been associated with Internet Gaming Disorder (IGD), its epidemiological impact on this emerging condition has not been systematically assessed. In this study, we ai...

Deficits in executive functions but not in decision making under risk in individuals with problematic social-network use.

Feb 15, 2021

The tendency to strive for immediate gratification by neglecting potential negative long-term outcomes characterizes addictive behaviors, such as substance use or gaming disorder. Problematic social-n...

Characterizing the building blocks of Problematic Use of the Internet (PUI): The role of obsessional impulses and impulsivity traits among Italian young adults.

Feb 15, 2021

Problematic Use of the Internet (PUI) is a considerable issue of the modern era, but its risk factors are still poorly understood. Impulsivity and obsessive-compulsive symptoms have been associated wi...

Carfentanil - from an animal anesthetic to a deadly illicit drug.

Feb 15, 2021

The use of novel synthetic opioids as recreational drugs has become a public health concern as they are implicated in numerous fatal intoxications across the world. Synthetic opioids have played a maj...

Tranexamic Acid Has No Effect on Post-operative Hemarthrosis or Pain Control Following ACL Reconstruction Using Bone Patella Tendon Bone Autograft: A Double-Blinded Randomized Control Trial.

Feb 04, 2021

The purpose of this double-blinded randomized controlled trial was to evaluate the use of intravenous (IV) tranexamic acid (TXA) in patients undergoing primary bone-patella tendon-bone (BTB) ACLR with...

Treatment retention and abstinence of patients with substance use disorders according to addiction severity and psychiatry comorbidity: A six-month follow-up study in an outpatient unit.

Feb 04, 2021

The impact of psychiatric comorbidity and addiction features throughout the course of addiction has been widely studied. This is a naturalistic study conducted in an outpatient unit, where treatment f...

A Clinical Trial of a Video Intervention Targeting Opioid Disposal After General Surgery: A Feasibility Study.

Feb 04, 2021

The opioid epidemic continues and although some initiatives have shown promise in reducing the number of opiates prescribed, few studies have focused on education of general surgery patients about hom...

Ketogenic diet for depression: A potential dietary regimen to maintain euthymia?

Jan 28, 2021

Approximately 30% of patients with major depressive disorder (MDD) present resistance to current pharmacological therapies. There is the possibility that an appropriate nutritional regimen can maintai...

Expanding access to methadone treatment in Ohio through federally qualified health centers and a chain pharmacy: A geospatial modeling analysis.

Jan 28, 2021

In the United States, methadone provision for opioid use disorder (OUD) occurs at opioid treatment programs (OTPs). Ohio recently enacted a policy to expand methadone administration to Federally Quali...