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Opioids

Sex differences in the effects of a combined behavioral and pharmacological treatment strategy for cocaine relapse prevention in an animal model of cue exposure therapy.

Aug 06, 2020

Brief interventions of environmental enrichment (EE) or the glycine transporter-1 inhibitor Org24598 administered with cocaine-cue extinction training were shown previously to inhibit reacquisition of...

Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates.

Aug 03, 2020

Preterm and full-term neonates undergo many painful procedures during their hospitalization in the neonatal intensive care unit. Unrelieved and repeated pain can have important repercussions on their ...

Do Meso-Limbic Gene Expression Findings from Mouse Models of Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder?

Jul 30, 2020

Animal models of drug use have been employed for over 100 years to facilitate the identification of mechanisms governing human substance use and addiction. Most cross-species research on drug use/ad...

Pandemic Presents New Hurdles, And Hope, For People Struggling With Addiction

Jun 04, 2020

Before Philadelphia shut down to slow the spread of the coronavirus, Ed had a routine: most mornings he would head to a nearby McDonald’s to brush his teeth, wash his face and — when he had th...

ASCO: Gastric Cancer Patients Respond to Trastuzumab Deruxtecan

Jun 02, 2020

Overall survival also extended with conjugate treatment In a small, phase II trial, patients with advanced gastric cancer were far more likely to respond to conjugate therapy with trastuzumab deruxte...

How COVID-19 Has Impacted the Opioid Crisis

May 07, 2020

When it comes to rates of infection and addiction, both the coronavirus pandemic and the opioid epidemic disproportionately impact the poorest and most vulnerable members of society. As physicians, it...

Individual differences in biological regulation: Predicting vulnerability to drug addiction, obesity, and other dysregulatory disorders.

Apr 28, 2020

Physiological regulation is so fundamental to survival that natural selection has greatly favored the evolution of robust regulatory systems that use both reactive and preemptive responses to mitigate...

Interventions to Support Family Caregivers in Pain Management: A Systematic Review.

Apr 28, 2020

Family caregivers encounter many challenges when managing pain for their loved ones. ​​There is a lack of clear recommendations on how to prepare caregivers in pain management.To evaluate existing...

Profile of cases discussed in innovative tele-ECHO mentoring program on addiction management.

Apr 28, 2020

NIMHANS ECHO (Extension for Community Healthcare Outcomes) model uses a video conferencing app to connect multiple community health care teams simultaneously with addiction treatment specialists and b...

Prevalence and predictors of hazardous alcohol use among tuberculosis patients: the need for a policy on joint tuberculosis-alcohol collaborative activities in India.

Apr 24, 2020

Collaborative activities to address tobacco addiction among tuberculosis (TB) patients are in place in India. The research was carried out to estimate the prevalence and to determine the predictors of...

Metasynthesis of Factors That Influence Parents' Participation in Pain Management for Their Infants in the NICU.

Apr 12, 2020

To metasynthesize the results of qualitative studies on the factors that affect parents' participation in pain management for their infants during procedures in the NICU.We conducted a literature sear...

GABAergic neurons in the insular cortex play an important role in cue-morphine reward memory reconsolidation.

Apr 12, 2020

There have been recent reports that reconsolidation-based interventions attenuate drug reward memories in rodents. The insular cortex (IC) is an essential part of neural circuits that underlie cue-dru...

Many Legal Marijuana Products Too Strong for Treating Pain

Apr 03, 2020

FRIDAY, April 3, 2020 (HealthDay News) -- Legally dispensed marijuana products have stronger concentrations of tetrahydrocannabinol (THC) and cannabidiol (CBD) than needed for chronic pain relief, acc...

Late-Life Depression Severity Varies by Race, Ethnicity

Mar 27, 2020

FRIDAY, March 27, 2020 (HealthDay News) -- Significant racial and ethnic differences have been identified in late-life depression (LLD) severity, symptom burden, and depression care, according to a st...

An operant social self-administration and choice model in rats.

Mar 24, 2020

It is difficult to translate results from animal research on addiction to an understanding of the behavior of human drug users. Despite decades of basic research on neurobiological mechanisms of drug ...

Inhaled Cannabis for Headache & Migraine

Mar 23, 2020

Today, a substantial proportion of medical cannabis users report using cannabis to manage headache and migraine, claiming that it is effective. However, research on the effectiveness of cannabis for t...

Physicians' and Attorneys' Beliefs and Attitudes Related to the Brain Disease Model of Addiction.

Mar 19, 2020

Addiction is increasingly considered a chronic, relapsing brain disease; however, many scholars still disagree with the brain disease model of addiction. We set out to provide evidence of attorneys' a...

ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine-addicted OSCC cells.

Mar 13, 2020

Alanine-serine-cysteine transporter 2 (ASCT2), a major glutamine transporter, is essential for cell growth and tumor development in a variety of cancers. However, the clinicopathological significance ...

Predicting Alcohol Dependence Treatment Outcomes: A Prospective Comparative Study of Clinical Psychologists vs 'Trained' Machine Learning Models.

Mar 10, 2020

Clinical staff are typically poor at predicting alcohol dependence treatment outcomes. Machine Learning (ML) offers the potential to model complex clinical data more effectively. This study tested the...

mGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia.

Mar 10, 2020

Consistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However,...