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Schizophrenia

Long-term safety and effectiveness of open-label lurasidone in antipsychotic-Naïve versus previously treated adolescents with Schizophrenia: A post-hoc analysis.

Jan 17, 2022

There is a relative lack of long-term, prospective data evaluating the safety and effectiveness of treatment in early-onset adolescent patients with schizophrenia who are treatment-naïve. The aim of ...

Outcomes for first-episode psychosis after entry via an at-risk mental state clinic compared to direct entry to a first episode of psychosis service: A systematic review and meta-analysis.

Jan 17, 2022

Early intervention for psychosis services have been established worldwide and consist of specialist services for those with the At-Risk Mental State (ARMS) and a first episode of psychosis (FEP). This...

Alterations of dynamic functional connectivity between visual and executive-control networks in schizophrenia.

Jan 10, 2022

Schizophrenia is a chronic mental disorder characterized by continuous or relapsing episodes of psychosis. While previous studies have detected functional network connectivity alterations in patients ...

Towards the understanding of state-independent neural traits underlying psychiatric disorders.

Jan 03, 2022

Hampered by the symptom complexity and diversity, the understanding of fundamental mechanisms underlying psychiatric disorders remains elusive. Traditional neuroscience research focusing on each behav...

Does social defeat cause negative symptoms? A prospective study in a multi-national community sample.

Dec 27, 2021

Psychological models of the consequences of ostracism (i.e. being socially excluded and ignored) and negative symptoms in schizophrenia suggest that repeatedly experiencing ostracism can lead to eleva...

The specific phenotype of depression in recent onset schizophrenia spectrum disorders: A symptom profile and network comparison to recent onset major depressive disorder without psychotic features.

Dec 27, 2021

The specific phenotype of depression in recent-onset schizophrenia spectrum disorders (SSD) and its relation to non-psychotic depression is unknown. Symptom profile and network analysis are complement...

Social distance towards schizophrenia in health professionals.

Dec 20, 2021

The stigma and prejudice of the public regarding psychiatric disorders are a long-standing social problem. However, health professionals are more likely to have negative attitudes and label people wit...

A novel event-related fMRI supervoxels-based representation and its application to schizophrenia diagnosis.

Nov 22, 2021

The schizophrenia diagnosis represents a difficult task because of the confusing descriptions of symptoms given by the patient, their similarity among several disorders, the lower familiarity with gen...

The Immune-Kynurenine Pathway in Social Anxiety Disorder.

Nov 15, 2021

The tryptophan-kynurenine pathway is of major interest in psychiatry and is altered in patients with depression, schizophrenia and panic disorder. Stress and immune alterations can impact this system,...

Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia.

Nov 08, 2021

Schizophrenia is a devastating psychiatric illness that detrimentally affects a significant portion of the worldwide population. Aging of schizophrenia patients is associated with reduced longevity, b...

Trends in big data analyses by multicenter collaborative translational research in psychiatry.

Nov 01, 2021

The underlying pathologies of psychiatric disorders, which cause substantial personal and social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core pathological mech...

Are we ready for a name change for schizophrenia? A survey of multiple stakeholders.

Oct 25, 2021

About one in 100 people worldwide are diagnosed with schizophrenia. Many people advocate for a name change for the condition, pointing to the stigma and discrimination associated with the term "schizo...

Cannabis use disorder and dissociation: A report from a prospective first-episode psychosis study.

Oct 25, 2021

Cannabis is the most used recreational drug worldwide. Its use can increase the risk of developing psychotic disorders and exacerbate their course. However, the relationship between cannabis use and d...

Volume Reduction of the Dorsal Lateral Prefrontal Cortex Prior to the Onset of Frank Psychosis in Individuals with an At-Risk Mental State.

Oct 18, 2021

Although some individuals with at-risk mental states (ARMS) develop overt psychosis, surrogate markers which can reliably predict a future onset of psychosis are not well established. The dorsal later...

Receptor density influences ligand-induced dopamine D receptor homodimerization.

Oct 11, 2021

Chronic treatments with dopamine D2 receptor ligands induce fluctuations in D2 receptor density. Since D2 receptors tend to assemble as homodimers, we hypothesized that receptor density might influenc...

Glial fibrillary acidic protein as blood biomarker for differential diagnosis and severity of major depressive disorder.

Oct 04, 2021

Neuroinflammation has been connected to the pathophysiology of major depressive disorder (MDD) and neurochemical biomarkers of glial pathology could aid the diagnosis and might support patient stratif...

A word is worth a thousand pictures: A 20-year comparative analysis of aberrant abstraction in schizophrenia, affective psychosis, and non-psychotic depression.

Sep 27, 2021

thinking is a cognitive process that involves the assimilation of concepts reduced from diffuse sensory input, organized, and interpreted in a manner beyond the obvious. There are multiple facets by w...

Alteration of power law scaling of spontaneous brain activity in schizophrenia.

Sep 27, 2021

Nonlinear dynamical analysis has been used to quantify the complexity of brain signal at temporal scales. Power law scaling is a well-validated method in physics that has been used to describe the dyn...

Altered Heschl's gyrus duplication pattern in first-episode schizophrenia.

Sep 20, 2021

Reduced gray matter volumes in the superior temporal gyrus and its subregions, such as Heschl's gyrus (HG) and the planum temporale (PT), have been reported in schizophrenia (Sz). However, it remains ...

Anomalous self-experiences (ASE) in relation to clinical high risk for psychosis (CHRP), childhood trauma and general psychopathology among adolescent and young adult help seekers.

Sep 20, 2021

Anomalous self-experiences (ASE) are suggested as a phenotypic core feature of schizophrenia spectrum disorders and present in at risk samples as well. In our study, we investigated the relation betwe...